28 results on '"Smith,Craig"'
Search Results
2. Parameteritis in patent claims - new diagnosis, old cures
- Author
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Smith, Craig
- Published
- 2021
3. First Isolation of Japanese Encephalitis Virus Genotype IV from Mosquitoes in Australia.
- Author
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Pyke, Alyssa T., Burtonclay, Peter, Poudel, Nirdesh, Ingall, Wayne, Nair, Neelima, Hall-Mendelin, Sonja, Craig, Scott B., Smith, Craig, Wang, Wei, Darbro, Jonathan M., Jansen, Cassie C., and van den Hurk, Andrew F.
- Subjects
JAPANESE encephalitis viruses ,MOSQUITO control ,MOSQUITOES ,WHOLE genome sequencing ,INSECT traps ,GENOTYPES ,REPORTING of diseases - Abstract
Introduction: Widespread transmission of Japanese encephalitis virus (JEV) genotype four (GIV) occurred across mainland Australia in 2022. This resulted in forty-five human cases, including seven deaths, and the identification of JEV infection in over 80 commercial piggeries. Materials and Methods: We collected mosquitoes which were trapped using CO
2 -baited light traps deployed near piggeries reporting disease or in regions linked to human cases in the Wide Bay region in the state of Queensland. Mosquitoes from four traps yielded JEV RNA by real-time RT-PCR. Pools containing RNA positive mosquitoes were inoculated onto mosquito cell monolayers. Discussion: A single isolate of JEV was obtained from a pool of mixed mosquito species. Near whole genome sequencing and phylogenetic analysis of the JEV isolate demonstrated its high genomic relatedness with JEV GIV pig sequences sampled from Queensland and the state of New South Wales in 2022. Conclusion: We report the first isolation of JEV GIV from mosquitoes collected in Australia. With only a few JEV GIV isolates available globally, the isolate we report will be essential for future research of JEV host interactions, evolution and disease markers, and development of effective therapies, vaccines, diagnostic assays, and mosquito control strategies. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
4. 1st person: APDR editor, KYM Bergmann, speaks with Professor Craig Smith, chief executive officer, EOS space systems
- Author
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Smith, Craig
- Published
- 2019
5. A Curriculum Innovation Framework for Science, Technology and Mathematics Education
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Tytler, Russell, Symington, David, and Smith, Craig
- Abstract
There is growing concern about falling levels of student engagement with school science, as evidenced by studies of student attitudes, and decreasing participation at the post compulsory level. One major response to this, the Australian School Innovation in Science, Technology and Mathematics (ASISTM) initiative, involves partnerships between schools and community and industry organisations in developing curriculum projects at the local level. This project fulfils many of the conditions advocated to engage students in learning in the sciences. ASISTM is underpinned by the notion of innovation. This paper describes the findings of case study research in which 16 ASISTM projects were selected as innovation exemplars. A definition of innovation and an innovation framework were developed, through which the case studies were analysed to make sense of the significance of the ideas and practices, participating actors, and outcomes of the projects. Through this analysis we argue that innovation is a powerful idea for framing curriculum development in the sciences at the local level that is generative for students and teachers, and that these ASISTM projects provide valuable models for engaging students, and for teacher professional learning.
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- 2011
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6. The potential for wine tourism in Beaudesert Shire
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CAUTHE (14th : 2004 : Brisbane, Qld.), Singer, Petra, and Smith, Craig Steve
- Published
- 2004
7. In Conversation with Ross Macaw QC.
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Smith, Craig
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INTELLECTUAL property ,ACTIONS & defenses (Law) - Published
- 2017
8. Spatiotemporal Aspects of Hendra Virus Infection in Pteropid Bats (Flying-Foxes) in Eastern Australia.
- Author
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Field, Hume, Jordan, David, Edson, Daniel, Morris, Stephen, Melville, Debra, Parry-Jones, Kerryn, Broos, Alice, Divljan, Anja, McMichael, Lee, Davis, Rodney, Kung, Nina, Kirkland, Peter, and Smith, Craig
- Subjects
SPATIOTEMPORAL processes ,VIRUS diseases ,BAT physiology ,ETIOLOGY of diseases ,SPECIES distribution ,HENDRA virus - Abstract
Hendra virus (HeV) causes highly lethal disease in horses and humans in the eastern Australian states of Queensland (QLD) and New South Wales (NSW), with multiple equine cases now reported on an annual basis. Infection and excretion dynamics in pteropid bats (flying-foxes), the recognised natural reservoir, are incompletely understood. We sought to identify key spatial and temporal factors associated with excretion in flying-foxes over a 2300 km latitudinal gradient from northern QLD to southern NSW which encompassed all known equine case locations. The aim was to strengthen knowledge of Hendra virus ecology in flying-foxes to improve spillover risk prediction and exposure risk mitigation strategies, and thus better protect horses and humans. Monthly pooled urine samples were collected from under roosting flying-foxes over a three-year period and screened for HeV RNA by quantitative RT-PCR. A generalised linear model was employed to investigate spatiotemporal associations with HeV detection in 13,968 samples from 27 roosts. There was a non-linear relationship between mean HeV excretion prevalence and five latitudinal regions, with excretion moderate in northern and central QLD, highest in southern QLD/northern NSW, moderate in central NSW, and negligible in southern NSW. Highest HeV positivity occurred where black or spectacled flying-foxes were present; nil or very low positivity rates occurred in exclusive grey-headed flying-fox roosts. Similarly, little red flying-foxes are evidently not a significant source of virus, as their periodic extreme increase in numbers at some roosts was not associated with any concurrent increase in HeV detection. There was a consistent, strong winter seasonality to excretion in the southern QLD/northern NSW and central NSW regions. This new information allows risk management strategies to be refined and targeted, mindful of the potential for spatial risk profiles to shift over time with changes in flying-fox species distribution. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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9. Natural Hendra Virus Infection in Flying-Foxes - Tissue Tropism and Risk Factors.
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Goldspink, Lauren K., Edson, Daniel W., Vidgen, Miranda E., Bingham, John, Field, Hume E., and Smith, Craig S.
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VIRUS diseases ,FLYING foxes ,VIRAL tropism ,ZOONOSES ,MEDICAL screening ,REVERSE transcriptase polymerase chain reaction ,HENDRA virus - Abstract
Hendra virus (HeV) is a lethal zoonotic agent that emerged in 1994 in Australia. Pteropid bats (flying-foxes) are the natural reservoir. To date, HeV has spilled over from flying-foxes to horses on 51 known occasions, and from infected horses to close-contact humans on seven occasions. We undertook screening of archived bat tissues for HeV by reverse transcription quantitative polymerase chain reaction (RT-qPCR). Tissues were tested from 310 bats including 295 Pteropodiformes and 15 Vespertilioniformes. HeV was detected in 20 individual flying-foxes (6.4%) from various tissues including spleen, kidney, liver, lung, placenta and blood components. Detection was significantly higher in Pteropus Alecto and P. conspicillatus, identifying species as a risk factor for infection. Further, our findings indicate that HeV has a predilection for the spleen, suggesting this organ plays an important role in HeV infection. The lack of detections in the foetal tissues of HeV-positive females suggests that vertical transmission is not a regular mode of transmission in naturally infected flying-foxes, and that placental and foetal tissues are not a major source of infection for horses. A better understanding of HeV tissue tropism will strengthen management of the risk of spillover from flying-foxes to horses and ultimately humans. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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10. Flying-Fox Species Density - A Spatial Risk Factor for Hendra Virus Infection in Horses in Eastern Australia.
- Author
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Smith, Craig, Skelly, Chris, Kung, Nina, Roberts, Billie, and Field, Hume
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FLYING foxes , *VIRUS diseases , *COMPUTATIONAL biology , *PARAMYXOVIRUSES , *ANIMAL diseases , *MEDICAL microbiology , *HENDRA virus - Abstract
Hendra virus causes sporadic but typically fatal infection in horses and humans in eastern Australia. Fruit-bats of the genus Pteropus (commonly known as flying-foxes) are the natural host of the virus, and the putative source of infection in horses; infected horses are the source of human infection. Effective treatment is lacking in both horses and humans, and notwithstanding the recent availability of a vaccine for horses, exposure risk mitigation remains an important infection control strategy. This study sought to inform risk mitigation by identifying spatial and environmental risk factors for equine infection using multiple analytical approaches to investigate the relationship between plausible variables and reported Hendra virus infection in horses. Spatial autocorrelation (Global Moran’s I) showed significant clustering of equine cases at a distance of 40 km, a distance consistent with the foraging ‘footprint’ of a flying-fox roost, suggesting the latter as a biologically plausible basis for the clustering. Getis-Ord Gi* analysis identified multiple equine infection hot spots along the eastern Australia coast from far north Queensland to central New South Wales, with the largest extending for nearly 300 km from southern Queensland to northern New South Wales. Geographically weighted regression (GWR) showed the density of P. alecto and P. conspicillatus to have the strongest positive correlation with equine case locations, suggesting these species are more likely a source of infection of Hendra virus for horses than P. poliocephalus or P. scapulatus. The density of horses, climate variables and vegetation variables were not found to be a significant risk factors, but the residuals from the GWR suggest that additional unidentified risk factors exist at the property level. Further investigations and comparisons between case and control properties are needed to identify these local risk factors. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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11. Hendra Virus Infection Dynamics in Australian Fruit Bats.
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Field, Hume, de Jong, Carol, Melville, Deb, Smith, Craig, Smith, Ina, Broos, Alice, Kung, Yu Hsin (Nina), McLaughlin, Amanda, and Zeddeman, Anne
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FRUGIVORES ,VIRUS diseases ,EQUUS ,PLASTIC sheets ,CANIDAE ,EXTRACELLULAR matrix proteins - Abstract
Hendra virus is a recently emerged zoonotic agent in Australia. Since first described in 1994, the virus has spilled from its wildlife reservoir (pteropid fruit bats, or 'flying foxes') on multiple occasions causing equine and human fatalities. We undertook a three-year longitudinal study to detect virus in the urine of free-living flying foxes (a putative route of excretion) to investigate Hendra virus infection dynamics. Pooled urine samples collected off plastic sheets placed beneath roosting flying foxes were screened for Hendra virus genome by quantitative RT-PCR, using a set of primers and probe derived from the matrix protein gene. A total of 1672 pooled urine samples from 67 sampling events was collected and tested between 1 July 2008 and 30 June 2011, with 25% of sampling events and 2.5% of urine samples yielding detections. The proportion of positive samples was statistically associated with year and location. The findings indicate that Hendra virus excretion occurs periodically rather than continuously, and in geographically disparate flying fox populations in the state of Queensland. The lack of any detection in the Northern Territory suggests prevalence may vary across the range of flying foxes in Australia. Finally, our findings suggest that flying foxes can excrete virus at any time of year, and that the apparent seasonal clustering of Hendra virus incidents in horses and associated humans (70% have occurred June to October) reflects factors other than the presence of virus. Identification of these factors will strengthen risk minimization strategies for horses and ultimately humans. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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12. Identifying Hendra Virus Diversity in Pteropid Bats.
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Smith, Ina, Broos, Alice, de Jong, Carol, Zeddeman, Anne, Smith, Craig, Smith, Greg, Moore, Fred, Barr, Jennifer, Crameri, Gary, Marsh, Glenn, Tachedjian, Mary, Meng Yu, Yu Hsin Kung, Lin-Fa Wang, and Field, Hume
- Subjects
PTEROPODIDAE ,ZOONOSES ,FOXES ,ANIMAL health ,NUCLEOTIDES - Abstract
Hendra virus (HeV) causes a zoonotic disease with high mortality that is transmitted to humans from bats of the genus Pteropus (flying foxes) via an intermediary equine host. Factors promoting spillover from bats to horses are uncertain at this time, but plausibly encompass host and/or agent and/or environmental factors. There is a lack of HeV sequence information derived from the natural bat host, as previously sequences have only been obtained from horses or humans following spillover events. In order to obtain an insight into possible variants of HeV circulating in flying foxes, collection of urine was undertaken in multiple flying fox roosts in Queensland, Australia. HeV was found to be geographically widespread in flying foxes with a number of HeV variants circulating at the one time at multiple locations, while at times the same variant was found circulating at disparate locations. Sequence diversity within variants allowed differentiation on the basis of nucleotide changes, and hypervariable regions in the genome were identified that could be used to differentiate circulating variants. Further, during the study, HeV was isolated from the urine of flying foxes on four occasions from three different locations. The data indicates that spillover events do not correlate with particular HeV isolates, suggesting that host and/or environmental factors are the primary determinants of bat-horse spillover. Thus future spillover events are likely to occur, and there is an on-going need for effective risk management strategies for both human and animal health. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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13. In Conversation with The Honourable Justice Susan Kenny.
- Author
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Smith, Craig
- Subjects
WOMEN judges ,VICTORIA. Court of Appeal - Abstract
An interview with Federal Court Justice Susan Kenny is presented. When asked about her work experience as an associate to Sir Ninian Stephen and its impact on her career, she refers her experience as the most remarkable one and her inspiration in going to the Victorian Bar. Kenny points out that she had experienced much conflict as the first woman being appointed to the Court of Appeal in Victoria. She also mentions her work as a part-time Commissioner for the Australian Law Reform Commission.
- Published
- 2010
14. Extreme mobility of the world's largest flying mammals creates key challenges for management and conservation.
- Author
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Welbergen, Justin A., Meade, Jessica, Field, Hume E., Edson, Daniel, McMichael, Lee, Shoo, Luke P., Praszczalek, Jenny, Smith, Craig, and Martin, John M.
- Subjects
FRAGMENTED landscapes ,ANIMAL mechanics ,ANIMAL sounds ,MAMMALS ,ECOSYSTEM services ,ZOONOSES - Abstract
Background: Effective conservation management of highly mobile species depends upon detailed knowledge of movements of individuals across their range; yet, data are rarely available at appropriate spatiotemporal scales. Flying-foxes (Pteropus spp.) are large bats that forage by night on floral resources and rest by day in arboreal roosts that may contain colonies of many thousands of individuals. They are the largest mammals capable of powered flight, and are highly mobile, which makes them key seed and pollen dispersers in forest ecosystems. However, their mobility also facilitates transmission of zoonotic diseases and brings them in conflict with humans, and so they require a precarious balancing of conservation and management concerns throughout their Old World range. Here, we analyze the Australia-wide movements of 201 satellite-tracked individuals, providing unprecedented detail on the inter-roost movements of three flying-fox species: Pteropus alecto, P. poliocephalus, and P. scapulatus across jurisdictions over up to 5 years. Results: Individuals were estimated to travel long distances annually among a network of 755 roosts (P. alecto, 1427–1887 km; P. poliocephalus, 2268–2564 km; and P. scapulatus, 3782–6073 km), but with little uniformity among their directions of travel. This indicates that flying-fox populations are composed of extremely mobile individuals that move nomadically and at species-specific rates. Individuals of all three species exhibited very low fidelity to roosts locally, resulting in very high estimated daily colony turnover rates (P. alecto, 11.9 ± 1.3%; P. poliocephalus, 17.5 ± 1.3%; and P. scapulatus, 36.4 ± 6.5%). This indicates that flying-fox roosts form nodes in a vast continental network of highly dynamic "staging posts" through which extremely mobile individuals travel far and wide across their species ranges. Conclusions: The extreme inter-roost mobility reported here demonstrates the extent of the ecological linkages that nomadic flying-foxes provide across Australia's contemporary fragmented landscape, with profound implications for the ecosystem services and zoonotic dynamics of flying-fox populations. In addition, the extreme mobility means that impacts from local management actions can readily reverberate across jurisdictions throughout the species ranges; therefore, local management actions need to be assessed with reference to actions elsewhere and hence require national coordination. These findings underscore the need for sound understanding of animal movement dynamics to support evidence-based, transboundary conservation and management policy, tailored to the unique movement ecologies of species. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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15. Diatoms control nutrient cycles in a temperate, wave-dominated estuary (southeast Australia).
- Author
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Haese, Ralf R., Murray, Emma J., Smith, Craig S., Smith, Jodie, Clementson, Lesley, and Heggie, David T.
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DIATOMS ,NUTRIENT cycles ,PHYTOPLANKTON ,PHOSPHORUS ,CARBON ,NITROGEN ,BIOMASS - Abstract
Diatoms are important primary producers within pelagic, benthic, and epiphytic communities, and their siliceous frustules sink rapidly to the sediment. We measured benthic nutrient and gas fluxes and water column and sediment properties in an estuary of southeastern Australia to identify control mechanisms coupling benthic and pelagic processes, in particular, how nutrients become fractionated by processes affecting benthic nutrient fluxes. During late spring, the water column of St. Georges Basin was oligotrophic, primary production was likely phosphorus (P) limited, and the phytoplankton community was dominated by cyanophytes. Molar ratios of dissolved inorganic carbon (TCO
2 ) to silica (Si) benthic fluxes, however, were equal to the molar composition of diatoms, indicating that diatoms preferentially sink and deliver the most labile organic matter fraction to the sediment. The congruent release of Si and carbon (C) implies a coupling of processes mobilizing Si and C. Extracellular polymeric substances surrounding the siliceous frustule are the primary labile organic matter fraction, and their rate of mineralization limits the dissolution of the siliceous frustule. Because decomposing biomass in sediments leads to net di-nitrogen (N2) production and very efficient burial of P, the fate of diatoms significantly contributes to the removal of bioavailable nutrients. High dissolved inorganic nitrogen to dissolved inorganic P benthic flux ratios of 290 to 900 promote P limitation, particularly in shallow waterbodies with long water residence times. [ABSTRACT FROM AUTHOR]- Published
- 2007
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16. World Briefing.
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Revkin, Andrew C., Kumar, Hari, Smith, Craig S., Bennhold, Katrin, Fuchs, Dale, Allam, Abeer, and Weiner, Tim
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NOBEL Prizes , *EX-presidents , *CORAL reefs & islands - Abstract
This article presents information on recent happenings in various parts of the world. The Nobel Prize medal awarded to Rabindranath Tagore, the Bengali poet, playwright and author, in 1913 was reported stolen from a museum in West Bengal, India. Indonesia's former president, Suharto, heads the list of leaders who are accused of having embezzled money from their countries over the past 20 years, according to a report. Australia will ban fishing on a third of the Great Barrier Reef, an Italy-size band of coral and fish along its northeast coast that has been degraded in recent decades.
- Published
- 2004
17. First Isolation of Japanese Encephalitis Virus Genotype IV from Mosquitoes in Australia.
- Author
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Pyke AT, Burtonclay P, Poudel N, Ingall W, Nair N, Hall-Mendelin S, Craig SB, Smith C, Wang W, Darbro JM, Jansen CC, and van den Hurk AF
- Subjects
- Animals, Australia epidemiology, Mosquito Vectors virology, Swine, Queensland epidemiology, Encephalitis, Japanese virology, Encephalitis, Japanese veterinary, Encephalitis, Japanese epidemiology, RNA, Viral genetics, Humans, Encephalitis Virus, Japanese genetics, Encephalitis Virus, Japanese isolation & purification, Encephalitis Virus, Japanese classification, Culicidae virology, Genotype, Phylogeny
- Abstract
Introduction: Widespread transmission of Japanese encephalitis virus (JEV) genotype four (GIV) occurred across mainland Australia in 2022. This resulted in forty-five human cases, including seven deaths, and the identification of JEV infection in over 80 commercial piggeries. Materials and Methods: We collected mosquitoes which were trapped using CO
2 -baited light traps deployed near piggeries reporting disease or in regions linked to human cases in the Wide Bay region in the state of Queensland. Mosquitoes from four traps yielded JEV RNA by real-time RT-PCR. Pools containing RNA positive mosquitoes were inoculated onto mosquito cell monolayers. Discussion: A single isolate of JEV was obtained from a pool of mixed mosquito species. Near whole genome sequencing and phylogenetic analysis of the JEV isolate demonstrated its high genomic relatedness with JEV GIV pig sequences sampled from Queensland and the state of New South Wales in 2022. Conclusion: We report the first isolation of JEV GIV from mosquitoes collected in Australia. With only a few JEV GIV isolates available globally, the isolate we report will be essential for future research of JEV host interactions, evolution and disease markers, and development of effective therapies, vaccines, diagnostic assays, and mosquito control strategies.- Published
- 2024
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18. A randomised controlled trial assessing the potential of palmitoylethanolamide (PEA) to act as an adjuvant to resistance training in healthy adults: a study protocol.
- Author
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Huschtscha Z, Fyfe JJ, Feros SA, Betik AC, Shaw CS, Main LC, Abbott G, Tan SY, Refalo MC, Gerhardy M, Grunwald E, May A, Silver J, Smith CM, White M, and Hamilton DL
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- Female, Humans, Adult, Adolescent, Young Adult, Pisum sativum, Australia, Muscle Strength, Analgesics pharmacology, Pain, Dietary Supplements adverse effects, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Muscle, Skeletal, Randomized Controlled Trials as Topic, Resistance Training methods
- Abstract
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics are used frequently by athletes either prophylactically for the prevention of pain, or to accelerate recovery following an injury. However, these types of pain management strategies have been shown to inhibit signalling pathways (e.g., cyclooxygenase-2) that may hinder muscular adaptations such as hypertrophy and strength. Nutraceuticals such as palmitoylethanolamide (PEA) have analgesic properties that act via different mechanisms to NSAIDS/analgesics. Furthermore, PEA has been shown to have a positive effect on sleep and may contribute positively to muscle hypertrophy via PKB activation. Although PEA has not been widely studied in the athletic or recreationally active population, it may provide an alternative solution for pain management if it is found not to interfere with, or enhance training adaptations. Therefore, the study aim is to investigate the effects of daily PEA supplementation (Levagen + ®) with resistance training on lean body mass, strength, power and physical performance and outcomes of recovery (e.g., sleep) compared to placebo., Methods: This double-blind, randomised controlled study will take place over an 11-week period (including 8-weeks of progressive resistance training). Participants for this study will be 18-35 years old, healthy active adults that are not resistance trained. Participants will attend a familiarisation (week 0), pre-testing (week 1) and final-testing (week 11). At the pre-testing and final-testing weeks, total lean body mass (dual-energy X-ray absorptiometry; DXA), total mid-thigh cross sectional area (pQCT), maximal muscular strength (1 repetition maximum bench press, isometric mid-thigh pull) and power (countermovement jump and bench throw) will be assessed. Additionally, circulating inflammatory cytokines and anabolic hormones, sleep quality and quantity (ActiGraph), pain and subjective wellbeing (questionnaires) will also be examined., Discussion: This study is designed to investigate the effects that PEA may have on pre-to post intervention changes in total body and regional lean muscle mass, strength, power, sleep, subjective wellbeing, and pain associated with resistance training and menstruation compared with the placebo condition. Unlike other NSAIDs and analgesics, which may inhibit muscle protein synthesis and training adaptations, PEA which provides analgesia via alternative mechanisms may provide an alternative pain management solution. It is therefore important to determine if this analgesic compound interferes with or enhances training adaptations so that athletes and active individuals can make an informed decision on their pain management strategies., Trial Registration: Australian New Zealand Clinical Trials Registry (ANZCTR: ACTRN12621001726842p)., (© 2023. The Author(s).)
- Published
- 2023
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19. Identification of a canine coronavirus in Australian racing Greyhounds.
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Smith CS, Lenz MF, Caldwell K, and Oakey J
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- Animals, Australia epidemiology, Dogs, Genotype, Coronavirus Infections epidemiology, Coronavirus Infections veterinary, Coronavirus, Canine genetics, Dog Diseases epidemiology, Parvovirus, Canine genetics
- Abstract
Coronavirus infection can cause a range of syndromes, which in dogs can include mild-to-severe enteritis that generally resolves rapidly. Fatalities can occur from coinfection with other pathogens, including canine parvovirus. Between late December 2019 and April 2020, canine coronavirus (CCoV) was detected in Australian racing Greyhounds that displayed signs of gastrointestinal disease. The CCoV was genotyped using high-throughput sequencing, recovering 98.3% of a type IIb CCoV, generally thought to cause a mild but highly contagious enteric disease. The Australian CCoV was almost identical (99.9%, whole-genome sequence) to another CCoV associated with an outbreak of severe vomiting in dogs in the United Kingdom at the same time (December 2019-March 2020).
- Published
- 2022
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20. Genome-scale molecular and phylogenetic characterization of Middle Point orbiviruses from Australia.
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Agnihotri K, Oakey J, Smith C, Weir R, Pyke A, and Melville L
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- Aedes virology, Animals, Australia, Cattle virology, Mosquito Vectors virology, Orbivirus classification, Orbivirus isolation & purification, Reoviridae Infections transmission, Reoviridae Infections veterinary, Reoviridae Infections virology, Species Specificity, Viral Proteins genetics, Genome, Viral genetics, Orbivirus genetics, Phylogeny
- Abstract
Middle Point orbivirus (MPOV) is an Australian arbovirus, belongs to the Yunnan orbivirus species found in China. First detected and reported from Beatrice Hill, Northern Territory (NT), MPOV has to date, only been exclusively reported from the NT, Australia. Whilst genetic characterization of MPOV has been previously described, only restricted to sequence information for segments 2 and 3 coding core protein VP2 and outer capsid protein VP3, respectively. This study presents for the first time nearly full-length genome sequences of MPOV, which represent 24 isolates collected over a span of more than 20 years from 1997 to 2018. Whilst the majority of isolates were sampled at Beatrice Hill, NT where MPOV is most frequently isolated, this report also describes the first two isolations of MPOV from Queensland (QLD), Australia. One of which is the first non-bovine isolate obtained from the mosquito vector Aedes vittiger . We further compared these MPOV sequences with known sequences of the Yunnan orbivirus and other known orbivirus sequences of mosquito origin found in Australia. The phylogenetic analyses indicate the Australian MPOV sequences are more closely related to each other than other known sequences of Yunnan orbivirus. Furthermore, MPOV sequences are closely related to sequences from the Indonesian isolate JKT-8650. The clustering of Australian sequences in the phylogenetic tree suggests the monophyletic lineage of MPOV circulating in Australia. Further, ongoing surveillance is required to assess the existence and prevalence of this or other yet undetected lineages of MPOV and other orbiviruses in Australia.
- Published
- 2021
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21. Routes of Hendra Virus Excretion in Naturally-Infected Flying-Foxes: Implications for Viral Transmission and Spillover Risk.
- Author
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Edson D, Field H, McMichael L, Vidgen M, Goldspink L, Broos A, Melville D, Kristoffersen J, de Jong C, McLaughlin A, Davis R, Kung N, Jordan D, Kirkland P, and Smith C
- Subjects
- Animals, Australia, Chiroptera classification, Feces virology, Female, Hendra Virus genetics, Henipavirus Infections transmission, Horse Diseases virology, Horses, Male, Mouth virology, Nose virology, Rectum virology, Serum virology, Species Specificity, Chiroptera virology, Hendra Virus isolation & purification, Henipavirus Infections veterinary, Henipavirus Infections virology, Urine virology
- Abstract
Pteropid bats or flying-foxes (Chiroptera: Pteropodidae) are the natural host of Hendra virus (HeV) which sporadically causes fatal disease in horses and humans in eastern Australia. While there is strong evidence that urine is an important infectious medium that likely drives bat to bat transmission and bat to horse transmission, there is uncertainty about the relative importance of alternative routes of excretion such as nasal and oral secretions, and faeces. Identifying the potential routes of HeV excretion in flying-foxes is important to effectively mitigate equine exposure risk at the bat-horse interface, and in determining transmission rates in host-pathogen models. The aim of this study was to identify the major routes of HeV excretion in naturally infected flying-foxes, and secondarily, to identify between-species variation in excretion prevalence. A total of 2840 flying-foxes from three of the four Australian mainland species (Pteropus alecto, P. poliocephalus and P. scapulatus) were captured and sampled at multiple roost locations in the eastern states of Queensland and New South Wales between 2012 and 2014. A range of biological samples (urine and serum, and urogenital, nasal, oral and rectal swabs) were collected from anaesthetized bats, and tested for HeV RNA using a qRT-PCR assay targeting the M gene. Forty-two P. alecto (n = 1410) had HeV RNA detected in at least one sample, and yielded a total of 78 positive samples, at an overall detection rate of 1.76% across all samples tested in this species (78/4436). The rate of detection, and the amount of viral RNA, was highest in urine samples (>serum, packed haemocytes >faecal >nasal >oral), identifying urine as the most plausible source of infection for flying-foxes and for horses. Detection in a urine sample was more efficient than detection in urogenital swabs, identifying the former as the preferred diagnostic sample. The detection of HeV RNA in serum is consistent with haematogenous spread, and with hypothesised latency and recrudesence in flying-foxes. There were no detections in P. poliocephalus (n = 1168 animals; n = 2958 samples) or P. scapulatus (n = 262 animals; n = 985 samples), suggesting (consistent with other recent studies) that these species are epidemiologically less important than P. alecto in HeV infection dynamics. The study is unprecedented in terms of the individual animal approach, the large sample size, and the use of a molecular assay to directly determine infection status. These features provide a high level of confidence in the veracity of our findings, and a sound basis from which to more precisely target equine risk mitigation strategies.
- Published
- 2015
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22. Flying-fox roost disturbance and Hendra virus spillover risk.
- Author
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Edson D, Field H, McMichael L, Jordan D, Kung N, Mayer D, and Smith C
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- Animals, Australia, Henipavirus Infections epidemiology, Hydrocortisone urine, Seasons, Chiroptera urine, Chiroptera virology, Hendra Virus isolation & purification
- Abstract
Bats of the genus Pteropus (flying-foxes) are the natural host of Hendra virus (HeV) which periodically causes fatal disease in horses and humans in Australia. The increased urban presence of flying-foxes often provokes negative community sentiments because of reduced social amenity and concerns of HeV exposure risk, and has resulted in calls for the dispersal of urban flying-fox roosts. However, it has been hypothesised that disturbance of urban roosts may result in a stress-mediated increase in HeV infection in flying-foxes, and an increased spillover risk. We sought to examine the impact of roost modification and dispersal on HeV infection dynamics and cortisol concentration dynamics in flying-foxes. The data were analysed in generalised linear mixed models using restricted maximum likelihood (REML). The difference in mean HeV prevalence in samples collected before (4.9%), during (4.7%) and after (3.4%) roost disturbance was small and non-significant (P = 0.440). Similarly, the difference in mean urine specific gravity-corrected urinary cortisol concentrations was small and non-significant (before = 22.71 ng/mL, during = 27.17, after = 18.39) (P= 0.550). We did find an underlying association between cortisol concentration and season, and cortisol concentration and region, suggesting that other (plausibly biological or environmental) variables play a role in cortisol concentration dynamics. The effect of roost disturbance on cortisol concentration approached statistical significance for region, suggesting that the relationship is not fixed, and plausibly reflecting the nature and timing of disturbance. We also found a small positive statistical association between HeV excretion status and urinary cortisol concentration. Finally, we found that the level of flying-fox distress associated with roost disturbance reflected the nature and timing of the activity, highlighting the need for a 'best practice' approach to dispersal or roost modification activities. The findings usefully inform public discussion and policy development in relation to Hendra virus and flying-fox management.
- Published
- 2015
- Full Text
- View/download PDF
23. Isolation of multiple novel paramyxoviruses from pteropid bat urine.
- Author
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Barr J, Smith C, Smith I, de Jong C, Todd S, Melville D, Broos A, Crameri S, Haining J, Marsh G, Crameri G, Field H, and Wang LF
- Subjects
- Animals, Australia, Paramyxoviridae Infections virology, Zoonoses virology, Chiroptera virology, Paramyxovirinae genetics, Paramyxovirinae isolation & purification, Urine virology
- Abstract
Bats have been found to harbour a number of new emerging viruses with zoonotic potential, and there has been a great deal of interest in identifying novel bat pathogens to determine the risk to human and animal health. Many groups have identified novel viruses in bats by detection of viral nucleic acid; however, virus isolation is still a challenge, and there are few reports of viral isolates from bats. In recent years, our group has developed optimized procedures for virus isolation from bat urine, including the use of primary bat cells. In previous reports, we have described the isolation of Hendra virus, Menangle virus and Cedar virus in Queensland, Australia. Here, we report the isolation of four additional novel bat paramyxoviruses from urine collected from beneath pteropid bat (flying fox) colonies in Queensland and New South Wales during 2009-2011., (© 2015 The Authors.)
- Published
- 2015
- Full Text
- View/download PDF
24. Health assessment of the Christmas Island flying fox (Pteropus melanotus natalis).
- Author
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Hall J, Rose K, Smith C, De Jong C, Phalen D, Austen J, and Field H
- Subjects
- Animals, Australia epidemiology, Blood Cell Count veterinary, Chiroptera microbiology, Chiroptera parasitology, Feces parasitology, Female, Male, Parasitic Diseases, Animal blood, Parasitic Diseases, Animal epidemiology, Parasitic Diseases, Animal parasitology, Reference Values, Blood Chemical Analysis veterinary, Chiroptera blood
- Abstract
During July-August 2010, 28 Christmas Island flying foxes (Pteropus melanotus natalis) were captured and anesthetized for examination, sample collection, and release to determine the potential role of disease in recent population declines. Measurements and samples were taken for morphologic, hematologic, biochemical, and parasitologic analysis. These are the first blood reference ranges reported for this species. These data are being used to inform investigations into conservation status and population management strategies for the Christmas Island flying fox.
- Published
- 2014
- Full Text
- View/download PDF
25. Evidence of bat origin for Menangle virus, a zoonotic paramyxovirus first isolated from diseased pigs.
- Author
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Barr JA, Smith C, Marsh GA, Field H, and Wang LF
- Subjects
- Animals, Australia epidemiology, Epidemics veterinary, Humans, Molecular Sequence Data, Phylogeography, RNA, Viral genetics, Rubulavirus classification, Rubulavirus genetics, Rubulavirus pathogenicity, Rubulavirus Infections epidemiology, Rubulavirus Infections transmission, Rubulavirus Infections virology, Species Specificity, Swine, Swine Diseases epidemiology, Swine Diseases virology, Zoonoses transmission, Zoonoses virology, Chiroptera virology, Rubulavirus isolation & purification, Rubulavirus Infections veterinary, Sus scrofa virology
- Abstract
Menangle virus (MenPV) is a zoonotic paramyxovirus capable of causing disease in pigs and humans. It was first isolated in 1997 from stillborn piglets at a commercial piggery in New South Wales, Australia, where an outbreak of reproductive disease occurred. Neutralizing antibodies to MenPV were detected in various pteropid bat species in Australia and fruit bats were suspected to be the source of the virus responsible for the outbreak in pigs. However, previous attempts to isolate MenPV from various fruit bat species proved fruitless. Here, we report the isolation of MenPV from urine samples of the black flying fox, Pteropus alecto, using a combination of improved procedures and newly established bat cell lines. The nucleotide sequence of the bat isolate is 94 % identical to the pig isolate. This finding provides strong evidence supporting the hypothesis that the MenPV outbreak in pigs originated from viruses in bats roosting near the piggery.
- Published
- 2012
- Full Text
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26. Cedar virus: a novel Henipavirus isolated from Australian bats.
- Author
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Marsh GA, de Jong C, Barr JA, Tachedjian M, Smith C, Middleton D, Yu M, Todd S, Foord AJ, Haring V, Payne J, Robinson R, Broz I, Crameri G, Field HE, and Wang LF
- Subjects
- Animals, Antibodies, Viral blood, Antibodies, Viral immunology, Australia, Chiroptera immunology, Ferrets, Guinea Pigs, Humans, Chiroptera virology, Genome, Viral immunology, Henipavirus genetics, Henipavirus immunology, Henipavirus isolation & purification, Henipavirus Infections blood, Henipavirus Infections genetics, Henipavirus Infections immunology, Henipavirus Infections virology, Immune Evasion, Immunity, Innate
- Abstract
The genus Henipavirus in the family Paramyxoviridae contains two viruses, Hendra virus (HeV) and Nipah virus (NiV) for which pteropid bats act as the main natural reservoir. Each virus also causes serious and commonly lethal infection of people as well as various species of domestic animals, however little is known about the associated mechanisms of pathogenesis. Here, we report the isolation and characterization of a new paramyxovirus from pteropid bats, Cedar virus (CedPV), which shares significant features with the known henipaviruses. The genome size (18,162 nt) and organization of CedPV is very similar to that of HeV and NiV; its nucleocapsid protein displays antigenic cross-reactivity with henipaviruses; and it uses the same receptor molecule (ephrin-B2) for entry during infection. Preliminary challenge studies with CedPV in ferrets and guinea pigs, both susceptible to infection and disease with known henipaviruses, confirmed virus replication and production of neutralizing antibodies although clinical disease was not observed. In this context, it is interesting to note that the major genetic difference between CedPV and HeV or NiV lies within the coding strategy of the P gene, which is known to play an important role in evading the host innate immune system. Unlike HeV, NiV, and almost all known paramyxoviruses, the CedPV P gene lacks both RNA editing and also the coding capacity for the highly conserved V protein. Preliminary study indicated that CedPV infection of human cells induces a more robust IFN-β response than HeV.
- Published
- 2012
- Full Text
- View/download PDF
27. Pteropid bats are confirmed as the reservoir hosts of henipaviruses: a comprehensive experimental study of virus transmission.
- Author
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Halpin K, Hyatt AD, Fogarty R, Middleton D, Bingham J, Epstein JH, Rahman SA, Hughes T, Smith C, Field HE, and Daszak P
- Subjects
- Animals, Australia, Female, Genome, Viral, Hendra Virus genetics, Hendra Virus immunology, Malaysia, Nipah Virus genetics, Nipah Virus immunology, Pregnancy, Chiroptera classification, Chiroptera virology, Disease Reservoirs veterinary, Hendra Virus isolation & purification, Henipavirus Infections transmission, Nipah Virus isolation & purification
- Abstract
Bats of the genus Pteropus have been identified as the reservoir hosts for the henipaviruses Hendra virus (HeV) and Nipah virus (NiV). The aim of these studies was to assess likely mechanisms for henipaviruses transmission from bats. In a series of experiments, Pteropus bats from Malaysia and Australia were inoculated with NiV and HeV, respectively, by natural routes of infection. Despite an intensive sampling strategy, no NiV was recovered from the Malaysian bats and HeV was reisolated from only one Australian bat; no disease was seen. These experiments suggest that opportunities for henipavirus transmission may be limited; therefore, the probability of a spillover event is low. For spillover to occur, a range of conditions and events must coincide. An alternate assessment framework is required if we are to fully understand how this reservoir host maintains and transmits not only these but all viruses with which it has been associated.
- Published
- 2011
- Full Text
- View/download PDF
28. Bats without borders: long-distance movements and implications for disease risk management.
- Author
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Breed AC, Field HE, Smith CS, Edmonston J, and Meers J
- Subjects
- Animals, Australia, Chiroptera virology, Female, Geography, Henipavirus Infections prevention & control, Henipavirus Infections transmission, Indonesia, Male, Movement, Nipah Virus, Papua New Guinea, Telemetry, Chiroptera physiology, Homing Behavior
- Abstract
Fruit bats of the genus Pteropus (commonly known as flying-foxes) are the natural hosts of several recently emerged zoonotic viruses of animal and human health significance in Australia and Asia, including Hendra and Nipah viruses. Satellite telemetry was used on nine flying-foxes of three species (Pteropus alecto n=5, P. vampyrus n=2, and P. neohibernicus n=2) to determine the scale and pattern of their long-distance movements and their potential to transfer these viruses between countries in the region. The animals were captured and released from six different locations in Australia, Papua New Guinea, Indonesia, and Timor-Leste. Their movements were recorded for a median of 120 (range, 47-342) days with a median total distance travelled of 393 (range, 76-3011) km per individual. Pteropus alecto individuals were observed to move between Australia and Papua New Guinea (Western Province) on four occasions, between Papua New Guinea (Western Province) and Indonesia (Papua) on ten occasions, and to traverse Torres Strait on two occasions. Pteropus vampyrus was observed to move between Timor-Leste and Indonesia (West Timor) on one occasion. These findings expand upon the current literature on the potential for transfer of zoonotic viruses by flying-foxes between countries and have implications for disease risk management and for the conservation management of flying-fox populations in Australia, New Guinea, and the Lesser Sunda Islands.
- Published
- 2010
- Full Text
- View/download PDF
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