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Case report: The clinicopathological features of a case consistent with large felid leucoencephalomyelopathy are described in a 19‐year‐old, zoo‐based Sumatran tiger in which degenerative vertebral disease, renal insufficiency, diaphragmatic hernia and cataracts were comorbid. The principal presenting sign was ataxia, with concurrent deterioration of vertebral stiffness and vision loss. Histological features included marked destruction of the white matter, the formation of large, bizarre astrocytes and accumulation of numerous foamy macrophages (gitter cells). Immunohistochemical investigation of reactive astrocytes revealed several different cytoplasmic proteins. Conclusion: This is the first reported case of large felid leucoencephalomyelopathy in Australia. [ABSTRACT FROM AUTHOR]