1. Preoperative physiotherapy is cost-effective for preventing pulmonary complications after major abdominal surgery: a health economic analysis of a multicentre randomised trial.
- Author
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Boden, Ianthe, Robertson, Iain K, Neil, Amanda, Reeve, Julie, Palmer, Andrew J, Skinner, Elizabeth H, Browning, Laura, Anderson, Lesley, Hill, Cat, Story, David, and Denehy, Linda
- Subjects
LUNG disease prevention ,ABDOMEN ,BREATHING exercises ,COST effectiveness ,HOSPITAL care ,LUNG diseases ,MEDICAL care costs ,MEDICAL cooperation ,MEDICAL rehabilitation ,PHYSICAL therapy ,PREOPERATIVE care ,RESEARCH ,STATISTICAL sampling ,SURGICAL complications ,RANDOMIZED controlled trials ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Is preoperative physiotherapy cost-effective in reducing postoperative pulmonary complications (PPC) and improving quality-adjusted life years (QALYs) after major abdominal surgery? Cost-effectiveness analysis from the hospitals' perspective within a multicentre randomised controlled trial with concealed allocation, blinded assessors and intention-to-treat analysis. Four hundred and forty-one adults awaiting elective upper abdominal surgery attending pre-anaesthetic clinics at three public hospitals in Australia and New Zealand. The experimental group received an information booklet and a 30-minute face-to-face session, involving respiratory education and breathing exercise training, with a physiotherapist. The control group received the information booklet only. The probability of cost-effectiveness and incremental net benefits was estimated using bootstrapped incremental PPC and QALY cost-effectiveness ratios plotted on cost-effectiveness planes and associated probability curves through a range of willingness-to-pay amounts. Cost-effectiveness modelling utilised 21-day postoperative hospital cost audit data and QALYs estimated from Short Form-Six Domain health utilities and mortality to 12 months. Preoperative physiotherapy had 95% probability of being cost-effective with an incremental net benefit to participating hospitals of A$4,958 (95% CI 10 to 9,197) for each PPC prevented, given that the hospitals were willing to pay $45,000 to provide the service. Cost-utility for QALY gains was less certain. Sensitivity analyses strengthened cost-effectiveness findings. Improved cost-effectiveness and QALY gains were detected when experienced physiotherapists delivered the intervention. Preoperative physiotherapy aimed at preventing PPCs was highly likely to be cost-effective from the hospitals' perspective. For each PPC prevented, preoperative physiotherapy is likely to cost the hospitals less than the costs estimated to treat a PPC after surgery. Potential QALY gains require confirmation. ACTRN12613000664741. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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