1. Hyaluronidase and degranulation inhibitors from the edible roots of Oenanthe javanica including seric acids F and G that were obtained by heating.
- Author
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Murata, Toshihiro, Katagiri, Tatsuo, Osaka, Masaaki, Yamauchi, Shohei, Yoshimura, Kenshi, Kawada, Manami, Fujii, Yu, Suzuki, Yuka, and Sasaki, Kenroh
- Subjects
HYALURONIDASES ,ACIDS ,SAPONINS ,VEGETABLE farming ,CHEMICAL structure ,LIGNANS ,ISOMERS ,DEHYDRATION reactions - Abstract
Oenanthe javanica is a vegetable grown in East Asia and Australia in which the roots and aerial parts are boiled together to make certain traditional dishes. Nineteen compounds (1-19) were isolated from O. javanica roots and the chemical structures of 2 new norlignans were determined. The inhibitory effects of the compounds on hyaluronidase and degranulation in RBL-2H3 cells were evaluated to determine antiallergic and antiinflammation activities. Saponins (2-4) and the new norlignan seric acid G (12) were among the active compounds identified. Seric acid G (12), a methoxy derivative of seric acid F (11), was obtained as an interconverting mixture of 3:1 trans - cis isomers. Seric acids F and G (11, 12) were derived from seric acids C (10) and E, respectively, by decarboxylation and dehydration reactions that occurred during heating. It was confirmed by HPLC analysis that all eleven of the O. javanica cultivars contained seric acid C (10). [ABSTRACT FROM AUTHOR]
- Published
- 2021
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