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Purpose: To examine associations between exercise heart rate (HRex) during a continuous-fixed submaximal fitness test (CF-SMFT) and an intermittent-variable protocol (semistandardized kicking drill [SSD]) in Australian Football athletes, controlling for external intensities, within-session scheduling, and environmental conditions. Methods: Forty-four professional male Australian Football athletes (22.8 [8.0] y) were monitored over 10 sessions involving a 3-minute CF-SMFT (12 km·h−1) as the first activity and a SSD administered 35.7 (8.0) minutes after the CF-SMFT. Initial heart rate and HRex were collected, with external intensities measured as average velocity (in meters per minute) and average acceleration–deceleration (in meters per second squared). Environmental conditions were sampled. A penalized hierarchical linear mixed model was tuned for a Bayesian information criterion minima using a 10-fold cross-validation, with out-of-sample prediction accuracy assessed via root-mean-squared error. Results: SSD average acceleration–deceleration, initial heart rate, temperature, and ground hardness were significant moderators in the tuned model. When model covariates were held constant, a 1%-point change in SSD HRex associated with a 0.4%-point change in CF-SMFT HRex (95% CI, 0.3–0.5). The tuned model predicted CF-SMFT HRex with an average root-mean-squared error of 2.64 (0.57) over the 10-fold cross-validation, with 74% and 86% of out-of-sample predictions falling within 2.7%-points and 3.7%-points, respectively, from observed values, representing the lower and upper limits for detecting meaningful changes in HRex according to the documented typical error. Conclusions: Our findings support the use of an SSD to monitor physiological state in Australian Football athletes, despite varied scheduling within session. Model predictions of CF-SMFT HRex from SSD HRex closely aligned with observed values, considering measurement imprecision. [ABSTRACT FROM AUTHOR]

Background: Submaximal fitness test (SMFT) outcome measures are frequently collected with a wide array of technologies and methodological approaches. Purpose: To examine the test–retest reliability of various SMFT outcome measures derived from different protocols and analytical techniques. Methods: Twenty-six semiprofessional adult soccer players performed 3 SMFT protocols, including 2 continuous (3 min, 11 and 12.8 km·h−1) and 1 intermittent (4 × 50 m, 18 km·h−1) twice, each separated by 7 days. Heart-rate (HR) indices (exercise HR, HR recovery) and scapula-mounted (PlayerLoad vector magnitude) and foot-mounted (flight time and contact time, stride length) microelectrical mechanical system–derived variables were collected using different time frames and analytical approaches adopted in the literature and practice. Absolute reliability was quantified as the group mean difference, typical error of measurement, also expressed as the coefficient of variation (where appropriate) and standardized units (ie, d). Intraclass correlation coefficient was used to quantify relative reliability. Results: The highest degrees of reliability were evident for exercise HR (typical error: 1.0%–1.6% points), the vertical component of PlayerLoad (expressed in arbitrary units; coefficient of variation: 5.5%–7.0%), and contact time (coefficient of variation: 1.5%–3.0%). These estimates were not influenced by SMFT protocol or analytical approach. All other measures displayed poorer reliability and/or were different between protocols and analytical methods. Conclusions: SMFT protocols impact the test–retest reliability of various outcome measures; however, exercise HR, vertical PlayerLoad, and contact time (derived from foot-mounted micro-electrical mechanical systems) appear to have stable measurement properties to assist the assessment of aerobic capacity and lower-limb neuromuscular status, respectively. [ABSTRACT FROM AUTHOR]

Background: Icanbelimod (formerly CBP-307) is a next-generation S1PR modulator, targeting S1PR1. In this first-in-human study, icanbelimod was investigated in healthy men in Australia. Methods: Participants were randomized 3:1, double-blind, to icanbelimod or placebo in four single-dose cohorts (0.1 mg, 0.25 mg, 0.5 mg [n=8 per cohort], 2.5 mg [n=4]) or for 28-days once-daily treatment in two cohorts (0.15 mg, 0.25 mg [n=8 per cohort]). Participants in the 0.25-mg cohort received 0.1 mg on Day 1. Treatments were administered orally after fasting; following one-week washout, icanbelimod was administered after breakfast in the 0.5-mg cohort. Results: Icanbelimod exposure increased rapidly and dose-dependently with single and multiple dosing (Tmax 4–7 hours). Lymphocyte counts decreased rapidly after single (-11%, 0.1 mg; -40%, 0.25 mg; -71%, 0.5 mg; -77%, 2.5 mg) and multiple doses (-49%, 0.15 mg; -75%, 0.25 mg), and recovered quickly, 7 days after dosing. After single-dose 0.5 mg, although a high-fat breakfast versus fasting did not affect maximal decrease, lymphocyte counts tended to be lower after breakfast across most timepoints up to 72 hours. Twenty-eight participants (63.6%) experienced mainly mild treatment-emergent adverse events (TEAEs). After single-dose icanbelimod, the most common TEAEs were headache (28.6%, n=6) and dizziness (19.0%, n=4). Three participants experienced transient bradycardia, with one serious, following single-dose 2.5 mg icanbelimod. After multiple-dose icanbelimod, the most common TEAEs were headache (50.0%, n=6) and lymphopenia (41.7%, n=5), and two participants withdrew due to nonserious TEAEs. Up-titration attenuated heart rate reductions. Conclusion: Icanbelimod was well-tolerated up to 0.5 mg and effectively reduced lymphocyte counts. [ABSTRACT FROM AUTHOR]

Simple Summary: Data collected from training sessions has the potential to better understand how well racehorses will perform on race-days. To date, no research has explored whether speed during and heart rate recovery after fast exercise could predict a horse winning a race. This theory was tested by analysing information from fitness trackers worn by 485 racehorses during training sessions in Australia by looking at factors like the horse's speed and heart rate recovery after exercise. The study found that certain factors, like being a colt or a 'stayer', were good indicators of future success on the racetrack. However, heart rate recovery and speed at the start or throughout the final 600 m during training were not as powerful as race predictors. Nevertheless, combining physiological data with other less tangible factors will help professionals identify which horses are more likely to perform at their best in races, aiding decision-making and potentially reducing race-day poor performance. Ultimately, this could lead to more successful outcomes for the horses, trainers and owners. In-training racehorse physiological data can be leveraged to further explore race-day performance prediction. To date, no large retrospective, observational study has analysed whether in-training speed and heart rate recovery can predict racehorse success. Speed (categorised as 'slow' to 'fast' according to the time taken to cover the last 600 m from a virtual finish line) and heart rate recovery (from gallop to 1 min after exercise) of flat racehorses (n = 485) of varying age, sex and type according to distance (e.g., sprinter, miler and stayer) were obtained using a fitness tracker from a single racing yard in Australia. Race-pace training sessions on turf comprised 'fast gallop' (n = 3418 sessions) or 'jumpout' (n = 1419). A posteriori racing information (n = 3810 races) for all 485 racehorses was extracted and combined with training data. Race performance was categorised as win/not-win or podium or not, each analysed by logistic regression. Colts (p < 0.001), stayers (p < 0.001) and being relatively fast over the last 600 m of a benchmark test in training (p < 0.008) were all predictive of race performance. Heart rate recovery after exercise (p = 0.21) and speed recorded at 600 m of a 1 km benchmark test in training (p = 0.94) were not predictive. In-training physiological data analytics used along with subjective experience may help trainers identify promising horses and improve decision-making. [ABSTRACT FROM AUTHOR]

BACKGROUND: Within individual policing organisations, there are a wide variety of units and job roles. OBJECTIVE: To profile the occupational tasks performed by Australian mounted police officers, aiming to offer conditioning insight into this unique job role. METHODS: Thirteen fully qualified and operational mounted police officers (n = 11 females), who served in the mounted police unit for ∼3.3 (±2.3) years, participated in this observational cohort study. Participants completed a survey outlining common occupational tasks and were monitored throughout four consecutive shifts. Participants' heart rate (HR), respiratory rate (RR), and skin temperature (ST) data were collected via wearable monitoring (Equivital EQ-02, Hidalgo, UK) and body position, physical activity undertaken, task effort, and load carriage were recorded by researchers. A one-way ANOVA was used to assess mean differences in physiological measures between the three most reported tasks. RESULTS: Survey identified 130 tasks, with 38 listed as most common. The three most reported mounted police tasks were: 'horse riding' (n = 13, 34%), 'mounted patrols' (n = 10, 26%), and 'horse care' (n = 10, 26%). These were also reported as the most physically demanding. HR during 'horse care' and 'horse riding' were significantly higher than when 'mounted patrolling' (27±7bpm, p = 0.001 and 33±8bpm; p = 0.001, respectively). Mean RR was higher when 'horse riding' when compared to 'horse care' (5.3±1.6brpm) and 'mounted patrol' (8.5±1.9brpm). CONCLUSION: Mounted police officers experience unique physiological challenges throughout their routine occupational tasks. This study highlights the significance of understanding occupation-specific tasks and stressors undertaken by mounted police to develop relevant conditioning, rehabilitation, and monitoring procedures. [ABSTRACT FROM AUTHOR]

BACKGROUND: Police Tactical Groups (PTGs) are specialist police units tasked with rigorous physical and psychosocial duties. Consequently, selection courses (SCs) for service in these units must also be rigorous. Given the intensity of SCs, holistic monitoring for potential overstress may be beneficial. Heart Rate Variability (HRV) is one holistic stress measure that can be obtained in austere environments. OBJECTIVE: The purpose of this study was to profile HRV during a PTG SC. Six (n = 6) qualified male police officers attempted a 36-hour PTG selection course held at an Australian state facility. METHODS: HRV was obtained from Equivitaltrademark EQ02 + LifeMonitor bioharnesses. The selection course consisted of physically demanding events with minimal sleep (approx. 45 mins). Only one candidate completed the full selection course; whose results are reported here. RESULTS: A visual time-series of 384 consecutive 5 min HRV analyses was generated. Contextual analysis was applied to appreciate HRV changes between SC serials. HRV decline occurred during the planning of a navigation exercise and a pack march. Increases in HRV were observed throughout the pack march exercise and rest period. CONCLUSION: This case study demonstrates the potential utility for selection personnel to obtain additional insight into candidate responses to various occupational challenges throughout an SC. Information provided by HRV monitoring may support leadership decisions when evaluating personnel holistically. For example, the ability to continue occupational task execution even while experiencing potential overstress (as measured by HRV) and after food and sleep deprivation is desirable. HRV may potentially inform stakeholders regarding overstress in PTG candidates. [ABSTRACT FROM AUTHOR]

Purpose: To describe the physiological (resting core temperature, exercising heart rate, and sweat rate) and psychophysical (rating of perceived exertion, thermal sensation, and thermal comfort) responses to a short-term heat acclimatization (HA) training camp in elite female rugby sevens athletes. Methods: Nineteen professional female rugby sevens athletes participated in a 5-day HA camp in Darwin, Australia (training average: 32.2°C and 58% relative humidity). Training involved normal team practice prescribed by appropriate staff. Markers of physiological and psychophysical adaptations to HA were collected at various stages during the camp. Partial eta-squared effect sizes (from linear mixed-effects models), rank-biserial correlations (from Freidman tests), and P values were used to assess changes across the protocol. Results: Resting core temperature did not significantly change. Exercising heart rate showed a large and significant reduction from day 1 to day 5 (175 [13] vs 171 [12] beats·min−1), as did sweat rate (1.1 [0.3] vs 1.0 [0.2] L·h–1). Thermal sensation showed a large and significant reduction between day 1 and day 5 (median [interquartile range] = 5 [5–5.5] vs 4.5 [4–5]). Changes in rating of perceived exertion and thermal comfort were unclear. Conclusions: Beneficial cardiovascular adaptations were observed simultaneously across a full squad of elite female rugby sevens players (without expensive facilities/equipment or modifying training content). However, beneficial changes in resting core temperature, sweat rate, and thermal/effort perceptions likely require a greater thermal impulse. These data contribute to the development of evidence-informed practice for minimal effective HA doses in female team-sport athletes, who are underrepresented in the current research. [ABSTRACT FROM AUTHOR]

This two-phase study involved the design, development, and evaluation of netball-specific high-intensity interval training sessions (Netball-HIIT) for use with netballers of varied ages and abilities. In Phase 1 (2020), a systematic analysis of netball GPS data from 30 netball players and gameplay video footage (10 h) was conducted, followed by the design and testing of five 8 min Netball-HIIT sessions involving 100 netball players (age 21 ± 8.44 years; Australia). In Phase 2 (2021), the feasibility and preliminary efficacy of delivering one Netball-HIIT session each week for five weeks was assessed using a two-armed, dose-matched, randomized, controlled feasibility study with netball players (born in 2010) (Netball HIIT n = 15; Netball Knee Program: NKP n = 15). Cardiorespiratory and muscular fitness was assessed at baseline and 6 weeks. Data were analyzed using linear mixed models and Cohen's d effect sizes. Netball-HIIT sessions were highly rated by players, and higher average (139 bpm) and peak heart rates (156 bpm) were detected amongst Netball-HIIT participants (KNP = 127 bpm and 152 bpm). We observed a large effect for cardiorespiratory fitness (+2.4 laps, d = 0.89), and a small to medium effect for muscular fitness (push-ups +1.2, d = 0.49; standing jump +0.8 cm, d = 0.36) in favor of Netball-HIIT, suggesting that coach-led Netball-HIIT may provide a time-efficient and effective training component for use in netball. [ABSTRACT FROM AUTHOR]

Police tactical group (PTG) personnel are exposed to physical, mental, and emotional stressors. Consequently, PTG selection courses (SCs) impart similar challenges, often resulting in candidate attrition. Holistic assessment may provide additional support to stakeholders given these risks. Heart Rate Variability (HRV) is an objective holistic stress measure that may be applicable in PTG SCs but has not been thoroughly researched. Therefore, this study aimed to report HRV data in an end-user accessible format and determine the relationship between HRV and attrition. A total of 18 qualified Australian State law enforcement officers completed a 1-day physical readiness assessment. Of those, six males progressed to an additional two-day course, on which this study is focused. This two-day selection consisted of additional physical challenges and occupational assessments. HRV was obtained from 2-lead ECGs and defined as the percentage of R-R intervals that varied by ≥50 ms (pRR50). Data were summarized in a heat map of consecutive short-term analyses. Three candidates withdrew. A logistic regression based on heat map data found high HRV was significant for predicting attrition, χ2 (6) = 8.318, p = 0.004. HRV may provide insight for PTG stakeholders monitoring attrition. While the sample size was limited and replication is needed, this study tentatively establishes value for HRV monitoring in PTG SCs. [ABSTRACT FROM AUTHOR]

Context: Exercise in hot environments increases body temperature and thermoregulatory strain. However, little is known regarding the magnitude of effect that ambient temperature (Ta), relative humidity (RH), and solar radiation individually have on team-sport athletes. Purpose: To determine the effect of these individual heat-stress variables on team-sport training performance and recovery. Methods: Professional Australian Rules Football players (N = 45) undertook 8-wk preseason training producing a total of 579 outdoor field-based observations with Ta, RH, and solar radiation recorded at every training session. External load (distance covered, in m/min; percentage high-speed running [%HSR] >14.4 km/h) was collected via a global positioning system. Internal load (ratings of perceived exertion and heart rate) and recovery (subjective ratings of well-being and heart-rate variability [root mean square of the successive differences]) were monitored throughout the training period. Mixed-effects linear models analyzed relationships between variables using standardized regression coefficients. Results: Increased solar-radiation exposure was associated with reduced distance covered (−19.7 m/min, P <.001), %HSR (−10%, P <.001) during training and rMSSD 48 h posttraining (−16.9 ms, P =.019). Greater RH was associated with decreased %HSR (−3.4%, P =.010) but increased percentage duration >85% HRmax (3.9%, P <.001), ratings of perceived exertion (1.8 AU, P <.001), and self-reported stress 24 h posttraining (−0.11 AU, P =.002). In contrast, higher Ta was associated with increased distance covered (19.7 m/min, P <.001) and %HSR (3.5%, P =.005). Conclusions: The authors show the importance of considering the individual factors contributing to thermal load in isolation for team-sport athletes and that solar radiation and RH reduce work capacity during team-sport training and have the potential to slow recovery between sessions. [ABSTRACT FROM AUTHOR]

Experiencing mental fatigue (MF) before an orienteering race can lead to a slower completion time. This study aimed to explore the changes in perceived MF, mood and other psychological responses during an orienteering competition. Sixteen national level orienteering athletes (20.8 ± 4.9 years) provided informed consent and completed the online surveys, before and immediately after each race, and 24- and 48-hours post competition (48POST). This study measured MF, physical fatigue, stress, tiredness and motivation using 0–100 Visual Analogue Scale, and the mood was assessed using The Brunel Mood Scale (BRUMS). A moderate to large increase in MF (ES = 0.93 [0.54 to 1.31]), BRUMS fatigue (ES = 0.61 [0.3 to 0.92]), and PF (ES = 1.21 [0.81 to 1.61]) was reported following orienteering races. A small increase in tiredness and BRUMS confusion, and a small decrease in motivation, stress and BRUMS vigour was also reported. There was a delay in recovering from the MF elicited by competition, with a small increase in MF (ES = 0.54 [0.08 to 1.15]) at 48POST compared to the pre-competition value. This study found that orienteers experience MF during competition and have a delayed recovery that can last up to two days after the competition. [ABSTRACT FROM AUTHOR]

Clonazolam is an unregistered novel benzodiazepine which emerged in global illicit drug markets in 2014. We describe the clinical features of four cases of non-fatal clonazolam mono-intoxications from patients presenting to emergency departments in Australia. Four patients aged between 16 and 19 years presented to hospital with a sedative toxidrome (Glasgow Coma Scale range 8–13) and elevated heart rate (median heart rate 100 beats per minute, range 92–105) following reported benzodiazepine exposure. Three patients reported the use of a large quantity (7–20 tablets) of Xanax®, a brand of alprazolam not commercially available in Australia. Two patients required nasopharyngeal airway insertion following the development of airway obstruction. The median time to return of a normal conscious state (Glasgow Coma Scale 15) was 23 h (range 5–30 h). Clonazolam (range 0.2–2.1 µg/L) and its main metabolite 8-aminoclonazolam (range 5.9–19.1 µg/L) were the only substances detected by liquid chromatography-tandem mass spectrometry in blood samples of all patients. Clonazolam intoxication resulted in sedation with mild sinus tachycardia. Three patients who reported multiple tablet exposures experienced prolonged sedation, and two of these patients developed airway obstruction. In this series, clonazolam was unknowingly ingested through possible illicit substitution within an unregulated counterfeit benzodiazepine product. [ABSTRACT FROM AUTHOR]

Objectives Despite recognition of clinical deterioration and medication-related harm as patient safety risks, the frequency of medication-related Rapid Response System activations is undefined. We aimed to estimate the incidence and preventability of medication-related Medical Emergency Team (MET) activations and describe the associated adverse medication events. Methods A case review study of consecutive MET activations at two acute, academic teaching hospitals in Melbourne, Australia with mature Rapid Response Systems was conducted. All MET activations during a 3-week study period were assessed for a medication cause including identification of the contributing adverse medication event and its preventability, using validated tools and recognised classification systems. Results There were 9439 admissions and 628 MET activations during the study period. Of these, 146 (23.2%) MET activations were medication related: an incidence of 15.5 medication-related MET activation per 1000 admissions. Medication-related MET activations occurred a median of 46.6 hours earlier (IQR 22-165) in an admission than non-medication-related activations (p=0.001). Furthermore, this group also had more repeat MET activations during their admission (p=0.021, OR=1.68, 95% CI 1.09 to 2.59). A total of 92 of 146 (63%) medication- related MET activations were potentially preventable. Tachycardia due to omission of beta-blocking agents (10.9%, n=10 of 92) and hypotension due to cumulative toxicity (9.8%, n=9 of 92) or inappropriate use (10.9%, n=10 of 92) of antihypertensives were the most common adverse medication events leading to potentially preventable medication-related MET activations. Conclusions Medications contributed to almost a quarter of MET activations, often early in a patient's admission. One in seven MET activations were due to potentially preventable adverse medication events. The most common of these were omission of beta-blockers and clinically inappropriate antihypertensive use. Strategies to prevent these events would increase patient safety and reduce burden on the MET. [ABSTRACT FROM AUTHOR]

The theoretical connections between off-site construction (OSC) and lean have only been marginally addressed in existing literature. This study analyses how distinct OSC strategies (1) affect flow and completion times, and (2) support simplification in construction (by reducing the number of parts and/or steps). Flow, which entails the smooth and reliable transfer of work across trades, is at the heart of lean whereas simplification is one principle of this management philosophy. Industry data based on three residential projects built in Australia using traditional construction or OSC strategies (panels/cassettes, and/or bathroom pods), and 15 hypothetical scenarios were used to develop a simulation exercise. The results show that OSC can substantially reduce schedule durations, particularly when different prefab elements are jointly used, but flow variability [measured by coefficient of variation (COV)] remains unchanged when compared to traditional construction. OSC was found to minimize the number of parts on-site by having building materials and components aggregated off-site and delivered as subassemblies. Yet, the number of steps did not reduce substantially, and the reductions only occurred when panels/cassettes were used. Alternative perspectives explaining the numerical results obtained are also discussed. The main contribution of this paper lies in measuring the impact of distinct OSC strategies from a flow viewpoint as well as in empirically examining their benefits from a simplification viewpoint. The study extends existing knowledge by leveraging industry data to quantify such impacts utilizing a tailored simulation approach. This provides an important addition to the still limited number of investigations measuring and comparing flow under different conditions. [ABSTRACT FROM AUTHOR]

This paper reports on a laboratory experiment designed specifically to test the influence of national pride on tax honesty while using a physiological marker to observe emotional responses to patriotic priming. Participants were exposed to one of three framing videos before earning income in a real effort task and were given the chance to declare their taxable income. We find that psychological priming through exposure to symbols of Australian national pride and national identity had a positive effect on the level of tax compliance among Australian but not non-Australians. In addition, non-Australians report lower tax compliance ratios in the treatment groups than in the control group which may indicate an outgroup effect. When exploring the potential of a physiological marker of national pride we observe two different types of physiological responses to the activation and effects of national pride and its impact on tax compliance among Australians. Iconic images activate the parasympathetic nervous system while sports scenes activate the sympathetic nervous system, but both types of images and responses are positively associated with tax compliance. In addition, we find that non-Australians resident in the country for more than a year report a higher level of tax compliance, and that there are some similarities in heart rate variability (HRV) responses between Australian citizens born in the country and those born overseas who have been in Australia for a longer period. Overall, the results support the proposition that identifying with an ingroup at a national level is important for tax compliance. [ABSTRACT FROM AUTHOR]

The present study aims to investigate the acute performance and physiological responses, with specific reference to muscle oxygenation, to ambient air temperature manipulation during repeated-sprint training in hypoxia (RSH). Thirteen male team-sport players completed one familiarisation and three experimental sessions at a simulated altitude of ∼3000 m (FIO2 0.144). Air temperatures utilised across the three experimental sessions were: 20°C, 35°C and 40°C (all 50% relative humidity). Participants performed 3 × 5 × 10-s maximal cycle sprints, with 20-s passive recovery between sprints, and 5 min active recovery between sets. There were no differences between conditions for cycling peak power, mean power, and total work (p>0.05). Peak core temperature (Tc) was not different between conditions (38.11 ± 0.36°C). Vastus lateralis muscle deoxygenation during exercise and reoxygenation during recovery was of greater magnitude in 35°C and 40°C than 20°C (p<0.001 for all). There was no condition × time interaction for Tc, skin temperature, pulse oxygen saturation, heart rate, rating of perceived exertion and thermal sensation (P>0.05). Exercise-induced increases in blood lactate concentration were higher in 35°C and 40°C than 20°C (p=0.010 and p=0.001, respectively). Integrating ambient temperatures up to 40°C into a typical RSH session had no detrimental effect on performance. Additionally, the augmented muscle oxygenation changes experienced during exercise and recovery in temperatures ≥35°C may indicate that the potency of RSH training is increased with additional heat. However, alterations to the training session may be required to generate a sufficient rise in Tc for heat training purposes. Highlights Heat exposure (35-40°C) did not affect mechanical performance during a typical RSH session. This indicates hot ambient temperature can be implemented during RSH, without negative consequence to training output. Hotter ambient conditions (35-40°C) likely result in greater muscle oxygenation changes during both exercise and recovery compared to temperate conditions. Although hotter sessions were perceived as more difficult and more thermally challenging, they did not further elevate Tc beyond that of temperate conditions. Accordingly, if intended to be used for heat acclimation purposes, alterations to the session may be required to increase heat load. [ABSTRACT FROM AUTHOR]

Objective: The aim of the study was to compare training and match loads for cerebral palsy football athletes in a state-level development program to assess the specificity of training for competition in the para sport. Design: Time-motion analysis and heart-rate monitoring were applied during 20 training sessions of the Western Australia CP Football 2017 training season and seven competition matches of the 2017 Australian National Championships. The study used an observational study design with between-subjects and within-subjects comparisons of training and match loads. Results: There were no significant differences between training and match loads in players' measurements of speed components and heart rates, with two exceptions: higher match distance covered in very high speed (g = 0.33) and time in heart rate zone 1 (<75% heart rate max, g = 0.45) and less time in heart rate zone 2 (g = 0.42). Conclusions: Our results indicate that the athletes were conditioned to perform at similar intensities implemented during training, as demonstrated by the consistency between competition and training data in total distance, relative speed zones, and relative heart rate zones. Coaches should apply this knowledge in the programming of training volume and intensities to obtain peak match fitness and specifically prepare athletes for competition in cerebral palsy football. [ABSTRACT FROM AUTHOR]

Objective: Cardiovascular autonomic neuropathy (CAN) is an overlooked but common and serious diabetes complication. We examined CAN in youth with diabetes and associations with cardiovascular risk factors. Research Design and Methods: This was a prospective cohort of youth aged <20 years with type 2 or type 1 diabetes (n = 66/1153, median age 15.4/16.5 years, duration 1.7/8.0 years), assessed between 2009 and 2020. CAN was defined as ≥2 abnormal heart rate variability measures across time, geometric, and frequency domains. Obesity was defined as BMI ≥ 95th percentile and severe obesity as ≥120% of 95th percentile. Multivariable generalized estimating equations (GEE) were used to examine putative risk factors for CAN, including diabetes type, obesity, and HbA1c. Results: At most recent assessment, youth with type 2 versus type 1 diabetes had median: HbA1c 7.1% (54 mmol/mol) versus 8.7% (72 mmol/mol) and BMI SDS (2.0 vs. 0.7); frequency of CAN (47% vs. 27%), peripheral nerve abnormality (47% vs. 25%), hypertension (29% vs. 12%), albuminuria (21% vs. 3%), and severe obesity (35% vs. 2%). In multivariable GEE, CAN was associated with type 2 diabetes: Odds Ratio 2.53, 95% CI 1.46, 4.38, p = 0.001, higher BMI SDS: 1.49, 95% CI 1.29, 1.73, p < 0.0001, and obesity: 2.09, 95% CI 1.57, 2.78, p < 0.0001. Conclusions: Youth with type 2 diabetes have a higher frequency of CAN, peripheral nerve abnormality, hypertension, albuminuria and severe obesity despite shorter diabetes duration and younger age. Our findings highlight the importance of targeting modifiable risk factors to prevent cardiovascular disease in youth with diabetes. [ABSTRACT FROM AUTHOR]

Aim: TransCon CNP is a novel prodrug designed to provide sustained release of C‐type natriuretic peptide (CNP) for once‐weekly therapy, addressing the pathology leading to aberrant skeletal development in achondroplasia. This phase 1 trial was initiated to assess the safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of TransCon CNP. Methods: This randomized, placebo‐controlled, single‐ascending dose phase 1 trial was performed at two sites in Australia and enrolled 45 healthy adult males. Subjects received placebo or TransCon CNP (single‐ascending dose cohorts [3, 10, 25, 75 or 150 μg CNP/kg]). The primary endpoint was frequency of adverse events and other safety outcomes. Other endpoints included PK and PD measured by cyclic guanosine‐monophosphate (cGMP) and amino‐terminal propeptide of CNP (NTproCNP). Results: TransCon CNP provided continuous systemic exposure to CNP over at least 7 days post‐dose. Plasma and urine levels of cGMP were significantly increased in subjects administered TransCon CNP at 75‐150 μg CNP/kg, indicating target engagement of active CNP at the natriuretic peptide receptor‐B (NPR‐B) for at least 1 week post‐dose. TransCon CNP was well‐tolerated, with no serious treatment‐emergent adverse events or discontinuations. Extensive cardiac safety assessments did not reveal any clinically relevant effects on electrocardiogram parameters, including heart rate, PR, QRS and QTcF intervals. Conclusions: Safety and PD data from this phase 1 trial support that TransCon CNP is well tolerated, with a PK profile compatible with a once‐weekly dosing regimen. Further studies are ongoing to evaluate the potential of TransCon CNP to positively impact abnormal endochondral ossification in children with achondroplasia. [ABSTRACT FROM AUTHOR]

Introduction: Autonomic nervous system functioning is theorised to underpin individual differences in sensory processing, with a small amount of supporting evidence. Despite recognition of the need to measure the balance between sympathetic and parasympathetic activity, most studies have measured only one of these systems. This study investigated whether sensory processing patterns are related to autonomic balance for young adults at rest and in response to a sensory-based stressor. Method: In this cross-sectional laboratory study, 100 young adults completed the adolescent/adult sensory profile. Heart rate variability and pre-ejection period were recorded before, during and after a coldpressor task. Results: Relationships between sensory processing patterns and autonomic balance varied by gender. In males, low sensory thresholds were generally related to a state of reciprocal sympathetic activation. In females, low thresholds were associated with greater autonomic reactivity in response to the coldpressor. Conclusion: This study showed, for the first time in young adults, that sensory processing patterns may be linked to patterns of autonomic balance. Therapists should be aware that young men with low sensory thresholds may be more likely than others to exhibit a resting state of sympathetic hyperarousal and further research should investigate whether this impacts their daily functioning and wellbeing. [ABSTRACT FROM AUTHOR]

The racing industry is supported by a predominance of female stablehands and work riders, but few become professional jockeys. Female jockeys have recently had notable race success. No study has assessed whether the sex of the rider may subtly influence racehorse physiology to affect performance. Here, using a validated exercise tracking system (the 'Equimetre'™) that records many physiological parameters simultaneously, this study characterised racehorse cardiovascular (heart rate, heart rate recovery) and biomechanical (stride length and frequency) parameters at various exercise intensities (slow canter to hard gallop) to address the question whether any parameter varied according to sex of the rider. A total of 530 Thoroughbreds, varying in age (2–7 years old) and sex (including geldings), from one racing yard in Australia, completed a total of 3,568 exercise sessions, monitored by a single trainer, on varying track surfaces (sand, turf, or fibre). Different work riders,103 in total (male, n = 66; female, n = 37) of which n = 43 were current or past registered professional jockeys, participated in the study. Data were analysed using analysis of variation (ANOVA) or mixed-effect models, as appropriate. Sex of the rider did not influence (P > 0.05) racehorse speed nor stride length at any training intensity. Racehorse heart rate and peak heart rate increased with training intensity (P <.001), with no difference according to sex of rider (P > 0.05). Racehorse heart rate recovery was influenced by sex of the rider, but only at the extremes of the reversed, usual training intensity on each surface (e.g. heart rate after galloping on sand was significantly lower with male riders, P = 0.03). Finally, analysis of 52,464 race results indicated a similar chance of a top-three placing for male and female jockeys. In conclusion, this study, using objectively obtained data, demonstrates for the first time no overt effect of the rider's sex on racehorse physiology in training and performance in racing. Such data could encourage greater female participation in racing and improve access of female jockeys to better quality mounts in racing events. [ABSTRACT FROM AUTHOR]

Background: Heart rate variability (HRV) is becoming one of the most valuable tools for assessing a healthy heart's complex and constantly changing oscillations. This study was a pioneering attempt to establish normative data on HRV during treadmill exercise for monitoring the cardiovascular health of the central Indian population. Methodology: This was a cross-sectional study in the Sports Physiology Laboratory of the Department of Physiology in a Rural Medical College in central India. One hundred and twenty healthy subjects in the age range 17-40 years were recruited. Short-term HRV (5 min) was extracted from ECG recordings obtained usingthe Power lab system, AD Instruments, Australia. Results: Time domain indices for males were - Standard deviation of N-N interval (SDNN): 162.61±162.11; Square root of mean squared difference of N-N intervals (RMSSD): 355.79±798.27; the percentage of adjacent NN intervals that differ from each other by more than 50 ms (pNN50): 23.10±27.87. Frequency domain indices in males were-LF power (%)-535.74±3625.96; HF power(%) - 33.15±24.31, LF nu: 33.12± 16.06; HF nu: 57.22±14.89; LF/HF:0.77±0.74. Time-domain indices for females were SDNN as 168.49±130.09; RMSSD: 182.41±154.85; pNN50:32.33±26.59. Frequency domain indicesin females were LF power (%)-19.85±6.13; HF power (%) 43.03±16.39, LF nu-30.53±9.88; HF nu - 60.95±8.70; LF/HF:0.54±0.27. Conclusion: Baseline normative values for HRV spectral and time-domain analysis have been established for their clinical use in comparing the HRV of a healthy individual to that of a deceased individual or an athlete. [ABSTRACT FROM AUTHOR]

Modern work environments have extensive interactions with technology and greater cognitive complexity of the tasks, which results in human operators experiencing increased mental workload. Air traffic control operators routinely work in such complex environments, and we designed tracking and collision prediction tasks to emulate their elementary tasks. The physiological response to the workload variations in these tasks was elucidated to untangle the impact of workload variations experienced by operators. Electroencephalogram (EEG), eye activity, and heart rate variability (HRV) data were recorded from 24 participants performing tracking and collision prediction tasks with three levels of difficulty. Our findings indicate that variations in task load in both these tasks are sensitively reflected in EEG, eye activity and HRV data. Multiple regression results also show that operators’ performance in both tasks can be predicted using the corresponding EEG, eye activity and HRV data. The results also demonstrate that the brain dynamics during each of these tasks can be estimated from the corresponding eye activity, HRV and performance data. Furthermore, the markedly distinct neurometrics of workload variations in the tracking and collision prediction tasks indicate that neurometrics can provide insights on the type of mental workload. These findings have applicability to the design of future mental workload adaptive systems that integrate neurometrics in deciding not just “when” but also “what” to adapt. Our study provides compelling evidence in the viability of developing intelligent closed-loop mental workload adaptive systems that ensure efficiency and safety in complex work environments. [ABSTRACT FROM AUTHOR]

O'Connor, FK, Doering, TM, Minett, GM, Reaburn, PR, Bartlett, JD and Coffey, VG. Effect of divergent solar radiation exposure with outdoor versus indoor training in the heat: implications for performance. J Strength Cond Res 36(6): 1622–1628, 2022—The aim of this study was to determine physiological and perceptual responses and performance outcomes when completing high-intensity exercise in outdoor and indoor hot environments with contrasting solar radiation exposure. Seven cyclists and 9 Australian Football League (AFL) players undertook cycling trials in hot conditions (≥30 °C) outdoors and indoors. Cyclists completed 5 × 4 minutes intervals (∼80% peak power output [PPO]) with 2 minutes recovery (∼40% PPO) before a 20-km self-paced ride. Australian Football League players completed a standardized 20 minutes warm-up (∼65% mean 4-minute power output) then 5 × 2 minutes maximal effort intervals. Heart rate (HR), PO, ratings of perceived exertion (RPE), thermal comfort (TC), and thermal sensation (TS) were recorded. Core (Tc) and skin temperature (Tsk) were monitored in cyclists alone. In both studies, ambient temperature, relative humidity, and solar radiation were monitored outdoors and matched for ambient temperature and relative humidity indoors, generating different wet bulb globe temperature (WBGT) for cyclists, but the similar WBGT for AFL players through higher relative humidity indoors. The statistical significance was set at p ≤ 0.05. Cyclists' HR (p = 0.05), Tc (p = 0.03), and Tsk (p = 0.03) were higher outdoors with variable effects for increased RPE, TS, and TC (d = 0.2–1.3). Power output during intervals was not different between trials, but there were small-moderate improvements in cyclists' PO and 20-km time indoors (d = 0.3–0.6). There was a small effect (d = 0.2) for AFL players' mean PO to increase outdoors for interval 4 alone (p = 0.04); however, overall there were small-moderate effects for lower RPE and TS indoors (d = 0.2–0.5). Indoor training in hot conditions without solar radiation may promote modest reductions in physiological strain and improve performance capacity in well-trained athletes. [ABSTRACT FROM AUTHOR]

Background: Viewing of visual imagery of forest or nature is known for producing physiological and psychological relaxation of mind and body. Nature surroundings are colourful and vary from green of plants, blue of water and red, orange, yellow and violet of flowers. These coloured imageries also known to affect our emotion; may lead to joy, sorrow, happiness grief etc. Heart Rate Variability (HRV) indexes through vagal activity the autonomic responses and thereby affects our emotions and behavioural outcome. This study is planned to assess the colour effects of visual imagery of coloured rose flowers on HRV in males and females for red, blue, green, indigo, yellow, orange and violet colours. Methodology: The Heart Rate Variability analysis was conducted on Power Lab AD Instruments, Australia in thirty healthy individuals (15 males and 15 females), aged between 20 to 40 years. Results: We observed variation in autonomic response to different colours in males and females on Heart Rate Variability assessment. There was augmentation of sympathetic drive on viewing of red, orange and violet colour roses in males and that of blue and violet colours in females. The visual imagery of blue, green, indigo and yellow coloured roses in males and red, green, indigo, yellow' and orange coloured in females produced a parasympathetic influence on Heart Rate Variability. Conclusion: Colours affects HRV and thereby can influence our emotional and behavioural responses in our daily life. Adapting to coloured surrounding of choice at workplace and at home may influence our work output and productivity as well produce physical and mental wellbeing. [ABSTRACT FROM AUTHOR]

Training load (TL) is monitored with the aim of making evidence-based decisions on appropriate loading schemes to reduce injuries and enhance team performance. However, little is known in detail about the variables of load and methods of analysis used in high-level football. Therefore, the aim of this study was to provide information on the practices and practitioners' perceptions of monitoring in professional clubs. Eighty-two high-level football clubs from Europe, the United States, and Australia were invited to answer questions relating to how TL is quantified, how players' responses are monitored, and their perceptions of the effectiveness of monitoring. Forty-one responses were received. All teams used GPS and heart-rate monitors during all training sessions, and 28 used rating of perceived exertion. The top-5-ranking TL variables were acceleration (various thresholds), total distance, distance covered above 5.5 m/s, estimated metabolic power, and heart-rate exertion. Players' responses to training are monitored using questionnaires (68% of clubs) and submaximal exercise protocols (41%). Differences in expected vs actual effectiveness of monitoring were 23% and 20% for injury prevention and performance enhancement, respectively (P < .001 d = 1.0-1.4). Of the perceived barriers to effectiveness, limited human resources scored highest, followed by coach buy-in. The discrepancy between expected and actual effectiveness appears to be due to suboptimal integration with coaches, insufficient human resources, and concerns over the reliability of assessment tools. Future approaches should critically evaluate the usefulness of current monitoring tools and explore methods of reducing the identified barriers to effectiveness. [ABSTRACT FROM AUTHOR]

Objective: To identify risk factors associated with delivery room respiratory support in at-risk infants who are initially vigorous and received delayed cord clamping (DCC).Design: Prospective cohort study.Setting: Two perinatal centres in Melbourne, Australia.Patients: At-risk infants born at ≥35+0 weeks gestation with a paediatric doctor in attendance who were initially vigorous and received DCC for >60 s.Main Outcome Measures: Delivery room respiratory support defined as facemask positive pressure ventilation, continuous positive airway pressure and/or supplemental oxygen within 10 min of birth.Results: Two hundred and ninety-eight infants born at a median (IQR) gestational age of 39+3 (38+2-40+2) weeks were included. Cord clamping occurred at a median (IQR) of 128 (123-145) s. Forty-four (15%) infants received respiratory support at a median of 214 (IQR 156-326) s after birth. Neonatal unit admission for respiratory distress occurred in 32% of infants receiving delivery room respiratory support vs 1% of infants who did not receive delivery room respiratory support (p<0.001). Risk factors independently associated with delivery room respiratory support were average heart rate (HR) at 90-120 s after birth (determined using three-lead ECG), mode of birth and time to establish regular cries. Decision tree analysis identified that infants at highest risk had an average HR of <165 beats per minute at 90-120 s after birth following caesarean section (risk of 39%). Infants with an average HR of ≥165 beats per minute at 90-120 s after birth were at low risk (5%).Conclusions: We present a clinical decision pathway for at-risk infants who may benefit from close observation following DCC. Our findings provide a novel perspective of HR beyond the traditional threshold of 100 beats per minute. [ABSTRACT FROM AUTHOR]

This study aimed to profile the physiological characteristics of junior sprint kayak athletes (n = 21, VO2max 4.1 ± 0.7 L/min, training experience 2.7 ± 1.2 y) and to establish the relationship between physiological variables (VO2max, VO2 kinetics, muscleoxygen kinetics, paddling efficiency) and sprint kayak performance. VO2max, power at VO2max, power:weight ratio, paddling efficiency, VO2 at lactate threshold, and whole-body and muscle oxygen kinetics were determined on a kayak ergometer in the laboratory. Separately, on-water time trials (TT) were completed over 200 m and 1000 m. Large to nearly perfect (-.5 to -.9) inverse relationships were found between the physiological variables and on-water TT performance across both distances. Paddling efficiency and lactate threshold shared moderate to very large correlations (-.4 to -.7) with 200- and 1000-m performance. In addition, trivial to large correlations (-.11 to -.5) were observed between muscle-oxygenation parameters, muscle and whole-body oxygen kinetics, and performance. Multiple regression showed that 88% of the unadjusted variance for the 200-m TT performance was explained by VO2max, peripheral muscle deoxygenation, and maximal aerobic power (P < .001), whereas 85% of the unadjusted variance in 1000-m TT performance was explained by VO2max and deoxyhemoglobin (P < .001). The current findings show that well-trained junior sprint kayak athletes possess a high level of relative aerobic fitness and highlight the importance of the peripheral muscle metabolism for sprint kayak performance, particularly in 200-m races, where finalists and nonfinalists are separated by very small margins. Such data highlight the relative aerobic-fitness variables that can be used as benchmarks for talent-identification programs or monitoring longitudinal athlete development. However, such approaches need further investigation. [ABSTRACT FROM AUTHOR]

Purpose: The aim of the current study was to quantify the physiological, psychometric, and performance effects of a 2-wk Christmas break in a professional Australian Football League club. Methods: A series of physiological (eg, heart-rate [HR] response to a 5-min submaximal run and skinfold thicknesses), psychometric (rating-of-perceived-exertion [RPE] responses and wellness variables), and performance (running activity during standardized handball games, isometric midthigh pull [IMTP] peak force, and countermovement jump [CMJ]) measures were conducted in the weeks before and after the break. Results: There was a possible and small increase in the sum of 7 skinfolds, while body mass and fat-free mass remained possible and likely unchanged, respectively. Sleep and stress scores remained likely to almost certainly unchanged, but there were some small, possible to likely decreases in fatigue and soreness scores. HR and RPE responses to the 5-min submaximal run were likely slightly lower (ie, improved) after the break. High-intensity running and acceleration distance during a standard handball game were very likely slightly greater, while HR and RPE responses to the game were possibly to very likely unchanged. HR responses to a high-intensity training session remained very likely unchanged. There was also a likely small increase in IMTP peak force but likely to very likely no change in CMJ variables. Conclusions: The results show that players returned from a 2-wk break during preseason well recovered, with preserved to improved levels of strength and cardiorespiratory fitness, despite small increases in skinfold thickness. [ABSTRACT FROM AUTHOR]

Some athletes avoid dairy in the meal consumed before exercise due to fears about gastrointestinal discomfort. Regular exclusion of dairy foods may unnecessarily reduce intake of high quality proteins and calcium with possible implications for body composition and bone health. This study compared the effects of meals that included (Dairy) or excluded (Control) dairy foods on gastric comfort and subsequent cycling performance. Well-trained female cyclists (n = 32; mean ± SD; 24.3 ± 4.1 y; VO2peak 57.1 ± 4.9 ml/kg/min) completed two trials (randomized cross-over design) in which they consumed a meal (2 g/kg carbohydrate and 54 kJ/kg) 2 hr before a 90-min cycle session (80 min at 60% maximal aerobic power followed by a 10-min time trial; TT). The dairy meal contained 3 servings of dairy foods providing ~1350 mg calcium. Gut comfort and palatability were measured using questionnaires. Performance was measured as maximum mean power during the TT (MMP10min). There was no statistical or clinical evidence of an effect of meal type on MMP10min with a mean difference (Dairy – Control) of 4 W (95% CI [–2, 9]). There was no evidence of an association between pretrial gut comfort and meal type (p = .15) or between gut comfort delta scores and meal type postmeal (p = .31), preexercise (p = .17) or postexercise (p = .80). There was no statistical or clinical evidence of a difference in palatability between meal types. In summary, substantial amounts of dairy foods can be included in meals consumed before strenuous cycling without impairing either gut comfort or performance. [ABSTRACT FROM AUTHOR]

Background: Women experience poorer health outcomes following acute coronary syndrome (ACS). Heart rate (HR) and heart rate variability (HRV) have emerged as sensitive and cost-effective markers of autonomic function and prognostic risk factors of poor cardiac outcomes. The aim of the current study was to investigate whether sex-specific differences existed across HR and five parameters of HRV, at 1 and 12 months following ACS diagnosis.Methods: Between January 2013 and June 2014, a sample of 416 ACS patients was enrolled in the Anxiety Depression & Heart Rate Variability in cardiac patients: Evaluating the impact of Negative emotions on functioning after Twenty four months (ADVENT) longitudinal cohort study. At 1 and 12 months following discharge, patient HR and HRV (root mean square of successive differences [RMSDD], standard deviation of RR intervals [SDRR], high frequency power [HF], low frequency power [LF], very low frequency power [VLF]) was measured via three-lead electrocardiogram.Results: At 1 month post-ACS, sex was a significant predictor of HR and VLF power in fully- adjusted models. At 12 months post-ACS, sex was a predictor of HR, SDRR and VLF power in fully-adjusted models.Conclusion: Sex-specific differences in resting HR and HRV were observed in the year following ACS, whereby women had higher HR and lower HRV, suggestive of poorer autonomic function. Further large-scale cohort studies examining autonomic function as a driver of sex-specific outcomes following ACS are required. [ABSTRACT FROM AUTHOR]

Objective: Skin-to-skin care (SSC) has proven psychological benefits; however, the physiological effects are less clearly defined. Regional ventilation patterns during SSC have not previously been reported. This study aimed to compare regional ventilation indices and other cardiorespiratory parameters during prone SSC with supine and prone position cot-nursing.Design: Prospective observational study.Setting: Single quaternary neonatal intensive care unit in Australia.Patients: 20 infants spontaneously breathing (n=17) or on non-invasive ventilation (n=3), with mean (SD) gestational age at birth of 33 (5) weeks.Interventions: Thirty-minute episodes of care in each position: supine cot care, prone SSC and prone cot care preceding a 10 min period of continuous electrical impedance tomography measurements of regional ventilation.Main Outcome Measures: In each position, ventral-dorsal and right-left centre of ventilation (CoV), percentage of whole lung ventilation by region and percentage of apparent unventilated lung regions were determined. Heart and respiratory rates, oxygen saturation and axillary temperature were also measured.Results: Heart and respiratory rates, oxygen saturation, temperature and right-left lung ventilation did not differ between the three positions (mixed-effects model). Ventilation generally favoured the dorsal lung, but the mean (95% CI) ventrodorsal CoV was -2.0 (-0.4 to -3.6)% more dorsal during SSC compared with prone. Supine position resulted in 5.0 (1.5 to 5.3)% and 4.5 (3.9 to 5.1)% less apparently unventilated lung regions compared with SSC and prone, respectively.Conclusions: In clinically stable infants, SSC generates a distinct regional ventilation pattern that is independent of prone position and results in greater distribution of ventilation towards the dorsal lung. [ABSTRACT FROM AUTHOR]

The poor physical health of patients with severe/chronic mental illness is now well‐known, yet little has been done to address the issue. Adverse medication effects, lifestyle, and social factors can all contribute to high morbidity and mortality rates when compared to the general population. To arrest poor physical health, a Wellness Clinic within a mental health hospital was developed to provide continuity of care when patients were discharged from the hospital. A retrospective, within‐subjects, quasi‐experimental, longitudinal time‐series study was conducted analysing the demographics and physical health parameters of 57 patients who remained with the service over a four and a half year time period. Assessments were taken at baseline, 12, 24, and 36 months for each individual. Despite increasing levels of psychotropic and other health medication over time, physical health parameters were generally held stable for most measures across the four time periods. HDL‐C levels were significantly improved between baseline and 36 months. This stability over time suggests that ongoing assessment, monitoring, and treatment is necessary to arrest the downward trajectory of poor physical health in mental health and opens the door for future research to invest in interventions to run alongside the Wellness Clinic and improve patient physical health. [ABSTRACT FROM AUTHOR]

Background: The incidence of ischaemic heart disease (IHD) has fallen consistently in the general population; attributed to effective primary prevention strategies. Differences in incidence have been demonstrated by sex. Whether this fall in incidence and sex differences is mirrored in people with end-stage kidney disease (ESKD) is unclear. We aimed to establish the relative risk of IHD events in the ESKD population.Methods: We performed a retrospective cohort study from 2000 to 2010 in people with ESKD in New South Wales. We performed data linkage of the Australia and New Zealand Dialysis and Transplant Registry and state wide hospital admission and death registry data and compared this to general population data. The primary outcome was the incidence rate, incidence rate ratio (IRR), and time-trend for any IHD event. We calculated these using indirect standardisation by IHD event.Results: 10,766 participants, contributed 44,149 years of observation time. Incidence rates were substantially higher than the general population for all IHD events (any IHD event: IRR 1.8, 95% confidence interval [CI] 1.7-1.9 for men, IRR 3.4, 95% CI 3.1-3.6 for women). Excess risk was higher in younger people (age 30-49 IRR 4.8, 95% CI 4.2-5.4), and in women with a three-fold increase risk overall and nearly a 10-fold increase in risk in young women (female age 30-49 years: IRR 9.8 95% CI 7.7-12.3), results were similar for angina and acute myocardial infarction. Ischaemic heart disease rates showed some decline for men over time, (ratio of IRR 0.93, 95% CI 0.90-0.95) but were stable for women (ratio of IRR 0.97, 95% CI 0.94-1.01).Conclusions: People with ESKD have substantially higher rates of IHD than the general population, especially women, in whom no improvement appears evident over the past 10 years. [ABSTRACT FROM AUTHOR]

Objective: Mental health problems among medical students have been widely reported, but the predisposing and perpetuating factors and biological concomitants are poorly understood. Adopting a biopsychosocial approach, we studied well-being in a group of Australian medical students, focusing on sleep, autonomic and immune mechanisms, as well as mental, social and physical well-being, health-related behaviours, and daily functioning. Methods: Fourth-year medical students (N = 151) completed comprehensive assessments, including laboratory-based and nocturnal autonomic monitoring via ambulatory bioharness, a psychiatric diagnostic interview, and questionnaires assessing sleep quality and psychosocial and physical well-being. A blood sample was taken to quantify the inflammatory marker C-reactive protein. Sleep, mood and activity was additionally monitored daily for 7 days. Results: A sizable minority of students reported diminished physical, mental and psychosocial well-being. We also found concerning levels of sleep disturbance and social and occupational impairment in a subset of students. The strong co-occurrence of problems across symptom domains supported a biopsychosocial interdependence of health and well-being states. Maladaptive coping behaviours were apparent, notably hazardous alcohol consumption, which was associated with a clinically significant elevation in C-reactive protein levels (> 3 mg/L). We documented, for the first time, significantly diminished nocturnal heart rate variability in medical students with a mental health diagnosis. Nocturnal heart rate variability was strongly associated with sleep quality, daytime autonomic stress reactivity, as well as occupational and social functioning. Conclusion: Well-being is a multifaceted phenomenon firmly interlinked with sleep, autonomic and immune function, health behaviours and functional outcomes. Our novel findings supported a key role for nocturnal autonomic function in promoting sleep quality and mental well-being. Interventions could focus on sleep hygiene and health behaviours as a buffer for well-being and teach more adaptive strategies for coping with the stresses of medical training. [ABSTRACT FROM AUTHOR]

Purpose: The main purpose of the present study was to quantify the match running demands and physiological intensities of AF field and boundary umpires during match play. Methods: Thirty-five AF umpires [20 field (age: 24.7 ± 7.7 y, body mass: 74.3 ± 7.1 kg, ∑7 skinfolds: 67.8 ± 18.8 mm); 15 boundary (age: 29.6 ± 13.6 y, body mass: 71.9 ± 3.1 kg, ∑7 skinfolds: 65.6 ± 8.8 mm)] volunteered to participate in the study. Movement characteristics [total distance (TD), average running speed, high-intensity activity (HIA; >14.4 km·h-1) distance] and physiological measures [heart rate, blood lactate concentration ([BLa−]), and rating of perceived exertion] were collected during 20 state-based AF matches. Results: The mean (± SD) TD covered by field umpires was 11,492 ± 1,729 m, with boundary umpires covering 15,061 ± 1,749 m. The average running speed in field umpires was 103 ± 14 m·min-1, and was 134 ± 14 m·min-1 in boundary umpires. Field and boundary umpires covered 3,095 ± 752 m and 5,875 ± 1,590 m, during HIA, respectively. In the first quarter, HIA distance (field: P = .004, η2 = 0.071, boundary: P < .001, η2 = 0.180) and average running speed (field: P = .002, η2 = 0.078, boundary: P < .001, η2 = 0.191) were significantly greater than in subsequent quarters. Conclusions: The results demonstrate that both AF field and boundary umpires complete similar running demands to elite AF players and are subject to physical fatigue. Further research is warranted to see if this physical fatigue impacts on the cognitive function of AF umpires during match play. [ABSTRACT FROM AUTHOR]

Purpose: To examine whether wearing various size lower-body compression garments improves physiological and performance parameters related to endurance running in well-trained athletes. Methods: Eleven well-trained middle-distance runners and triathletes (age: 28.4 ± 10.0 y; height: 177.3 ± 4.7 cm; body mass: 72.6 ± 8.0 kg; VO2max: 59.0 ± 6.7 mL-kg-1.min-11) completed repeat progressive maximal tests (PMT) and time-to-exhaustion (TTE) tests at 90% VO2max wearing either manufacturer-recommended LBCG (rLBCG), undersized LBCG (uLBCG), or loose running shorts (CONT). During all exercise testing, several systemic and peripheral physiological measures were taken. Results: The results indicated similar effects of wearing rLBCG and uLBCG compared with the control. Across the PMT, wearing either LBCG resulted in significantly (P < .05) increased oxygen consumption, O2 pulse, and deoxyhemoglobin (HHb) and decreased running economy, oxyhemoglobin, and tissue oxygenation index (TOI) at low-intensity speeds (8-10 km.h-1)- At higher speeds (12-18 km.h-1). wearing LBCG increased regional blood flow (nTHI) and HHb values, but significantly lowered heart rate and TOI. During the TTE, wearing either LBCG significantly (P < .05) increased HHb concentration, whereas wearing uLBCG also significantly (P < .05) increased nTHI. No improvement in endurance running performance was observed in either compression condition. Conclusion: The results suggest that wearing LBCG facilitated a small number of cardiorespiratory and peripheral physiological benefits that appeared mostly related to improvements in venous flow. However, these improvements appear trivial to athletes, as they did not correspond to any improvement in endurance running performance. [ABSTRACT FROM AUTHOR]

Purpose: This study evaluated the validity of ergometer tests against the criterion of on-water rowing and determined the reliability of field measurements by comparing results between ergometer (ERG) and on-water (OW) tests. Methods: Seven male rowers completed incremental tests on a Concept2 rowing ergometer and in a single scull. Average power output, oxygen consumption (VO2), heart rate (HR), blood lactate concentration (BLa) and distance completed were measured during each ERG and OW workload. Data treatment: Linear regression between power output and HR, BLa, VO2 and distance allowed submaximal results to be compared between ERG and OW tests at equivalent intensities based on five standard power outputs. Submaximal results were analyzed using repeated measure factorial ANOVAs and maximal data used dependent t tests (P < .05), the magnitude of differences were also classified using effect size analyses. The reliability of repeated measurements was established using Typical Error. Results: Differences between ERG and OW submaximal results were not statistically significant for power output, HR, BLa, and VO2, but distance completed (P < .001) was higher during the ERG test. However, the magnitude of physiological response differences between the ERG and OW tests varied between individuals. Mean HR at anaerobic threshold showed good agreement between both tests (r = .81), but the standard error of the estimate was 9 beats per minute. Conclusions: Individual variation in physiological response differences between ERG and OW tests meant that training intensity recommendations from the ERG test were not applicable to on-water training for some rowers, but provided appropriate prescriptions for most athletes. [ABSTRACT FROM AUTHOR]

BACKGROUND: Given the physical demands of mining and rescue operations, a physical employment standard was warranted to ensure capable workers are selected. While evaluations of muscular strength and muscular and cardiorespiratory endurance domains are common, assessment of a worker's ability to meet the physically demanding postural requirements is often neglected. OBJECTIVE: The aim of this investigation was to develop a valid assessment for NSW Mines Rescue Brigadesmen that replicated the combined muscular and cardiorespiratory endurance and postural demands of constructing a timber pillar. METHODS: Oxygen consumption () V ̇ O2) was measured and dominant postures identified when incumbent Brigadesmen constructed a timber pillar. A shelf-stacking assessment was designed and validated. RESULTS: When Brigadesmen performed the block placement role, the task elicited a mean V ̇ O2 of 1.6 L.min–1, and required repeated placement of ∼8.7 kg blocks from 0 to 3.0 m. A shelf stacking assessment (5 min, mean V ̇ O2 1.7 L.min–1) replicating dominant postures and requiring repeated block placement at 0, 0.65, 1.10, 1.64 and 2.20 m was developed. The demand of the test, performed within a discontinuous circuit, was subsequently verified (1.6 L.min–1). CONCLUSIONS: A valid, physiological aptitude test that considered the job-related movement patterns, in addition to cardiorespiratory and muscular endurance requirements, was developed for Brigadesmen. [ABSTRACT FROM AUTHOR]

The purpose of this investigation was to assess the merit of sports compression socks in minimizing travel-induced performance, physiological, and hematological alterations in elite female volleyball athletes. Twelve elite female volleyballers (age, 25 ± 2 years) traveled from Canberra (Australia) to Manila (Philippines), and were assigned to 1 of 2 conditions; compression socks (COMP, n = 6) worn during travel or a pas¬sive control (CON, n = 6). Dependent measures included countermovement jump (CMJ) performance, subjective ratings of well-being, cardiovascular function, calf girth, and markers of blood clotting, collected before (-24 hours, CMJ; -12 hours, all measures), during (+6.5 and +9 hours, subjective ratings and cardiovascular function), and after (+12 hours, all measures except CMJ; +24 hours and +48 hours, CMJ) travel. When compared with CON, small-to-large effects were observed for COMP to improve heart rate (+9 hours), oxygen saturation (+6.5 hours and +9 hours), alertness (+6.5 hours), fatigue (+6.5 hours), muscle soreness (+6.5 hours and +9 hours), and overall health (+6.5 hours) during travel. After travel, small-to-moderate effects were observed for COMP to improve systolic blood pressure (+12 hours), right calf girth (+12 hours), CMJ height (+24 hours), mean velocity (+24 hours), and relative power (+48 hours), compared with CON. COMP had no effect on the markers of blood clotting. This study suggests that compression socks are beneficial in combating the stressors imposed by long-haul travel in elite athletes, and may have merit for individuals frequenting long-haul travel or competing soon after flying. [ABSTRACT FROM AUTHOR]

While implantable cardioverter defibrillators decrease mortality in high risk groups of patients who have ventricular arrhythmias, antiarrhythmic drugs are still required to reduce the burden of both benign and life-threatening arrhythmias. This review will address the available medical therapy for ventricular arrhythmias in Australia and their use in different clinical situations. [ABSTRACT FROM AUTHOR]

Objective: With the intention to inform future public health initiatives, we aimed to determine the extent to which typical childhood dietary trajectories predict adolescent cardiovascular phenotypes.Design: Longitudinal study. Exposure was determined by a 4 d food diary repeated over eight waves (ages 4-15 years), coded by Australian Dietary Guidelines and summed into a continuous diet score (0-14). Outcomes were adolescent (Wave 8, age 15 years) blood pressure, resting heart rate, pulse wave velocity, carotid intima-media thickness, retinal arteriole-to-venule ratio. Latent class analysis identified 'typical' dietary trajectories from childhood to adolescence. Adjusted linear regression models assessed relationships between trajectories and cardiovascular outcomes, adjusted for a priori potential confounders.Setting: Community sample, Melbourne, Australia.Subjects: Children (n 188) followed from age 4 to 15 years.Results: Four dietary trajectories were identified: unhealthy (8 %); moderately unhealthy (25 %); moderately healthy (46 %); healthy (21 %). There was little evidence that vascular phenotypes associated with the trajectories. However, resting heart rate (beats/min) increased (β; 95 % CI) across the healthy (reference), moderately healthy (4·1; -0·6, 8·9; P=0·08), moderately unhealthy (4·5; -0·7, 9·7; P=0·09) and unhealthy (10·5; 2·9, 18·0; P=0·01) trajectories.Conclusions: Decade-long dietary trajectories did not appear to influence macro- or microvascular structure or stiffness by mid-adolescence, but were associated with resting heart rate, suggesting an early-life window for prevention. Larger studies are needed to confirm these findings, the threshold of diet quality associated with these physiological changes and whether functional changes in heart rate are followed by phenotypic change. [ABSTRACT FROM AUTHOR]

Abstract: Background: Effective management of cardiovascular and chronic kidney disease risk factors offers longer, healthier lives and savings in healthcare. Aim: To examine risk factor management in participants of the SCReening Evaluation of the Evolution of New Heart Failure study, a self‐selected population at increased cardiovascular disease risk recruited from members of a health insurance fund in Melbourne and Shepparton, Australia. Methods: Inclusion criteria were age ≥ 60 years with one or more self‐reported ischaemic or other heart diseases, irregular or rapid heart rhythm, cerebrovascular disease, renal impairment or treatment for hypertension or diabetes for ≥2 years. Exclusion criteria were known heart failure or cardiac abnormality on echocardiography or other imaging. Medical history, clinical examination, full blood examination and biochemistry (without lipids and glycated haemoglobin (HbA1c)) were performed for 3847 participants on enrolment, and blood pressure, lipids and HbA1c were measured 1–2 years after enrolment for 3203 participants. Results: Despite 99% of 3294 participants with hypertension receiving antihypertensive medication, half had blood pressures >140/90 mmHg. Approximately 77% of participants were overweight or obese, with one third being obese. Additionally, 74% of participants at high cardiovascular disease risk had low‐density lipoprotein cholesterol levels ≥2 mmol/L, one third of diabetic participants had HbA1c >7%, 22% had an estimated glomerular filtration rate < 60 mL/min/1.73m2, and substantial proportions had under‐utilisation of antiplatelet therapy and anticoagulation for atrial fibrillation and were physically inactive. Conclusions: This population demonstrated substantial potential to reduce cardiovascular and renal morbidity and mortality and healthcare costs through more effective management of modifiable risk factors. [ABSTRACT FROM AUTHOR]