25 results on '"Edwards, R."'
Search Results
2. Mistaken consumer electronic payments: An Australian solution?
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Edwards, R. R.
- Subjects
LAW ,ELECTRONIC funds transfer laws ,CONSUMER law - Abstract
The increasing use by consumers of electronic payment systems runs the risk that they may make mistakes. This is especially true when a system only uses numbers and not names. This article explores the problem of trying to recover such mistaken payments at common law and the situation in the United Kingdom and the United States, as well as examining the Australian position under the ePayments Code. The various solutions are assessed as to whether they are efficient: the cost, rule simplicity, and accessibility are focused upon in an attempt to determine this. [ABSTRACT FROM AUTHOR]
- Published
- 2015
3. Evaluation of implementation of a healthy food and drink supply strategy throughout the whole school environment in Queensland state schools, Australia.
- Author
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Dick, M, Lee, A, Bright, M, Turner, K, Edwards, R, Dawson, J, and Miller, J
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CHILD nutrition ,FOOD supply ,SCHOOL environment ,STAKEHOLDERS ,VENDING machines ,SCHOOL breakfast programs - Abstract
Background/objectives:This paper reports on the evaluation of the Smart Choices healthy food and drink supply strategy for Queensland schools (Smart Choices) implementation across the whole school environment in state government primary and secondary schools in Queensland, Australia.Subjects/methods:Three concurrent surveys using different methods for each group of stakeholders that targeted all 1275 school Principals, all 1258 Parent and Citizens' Associations (P&Cs) and a random sample of 526 tuckshop convenors throughout Queensland. Nine hundred and seventy-three Principals, 598 P&Cs and 513 tuckshop convenors participated with response rates of 78%, 48% and 98%, respectively.Results:Nearly all Principals (97%), P&Cs (99%) and tuckshop convenors (97%) reported that their school tuckshop had implemented Smart Choices. The majority of Principals and P&Cs reported implementation, respectively, in: school breakfast programs (98 and 92%); vending machine stock (94 and 83%); vending machine advertising (85 and 84%); school events (87 and 88%); school sporting events (81 and 80%); sponsorship and advertising (93 and 84%); fundraising events (80 and 84%); and sporting clubs (73 and 75%). Implementation in curriculum activities, classroom rewards and class parties was reported, respectively, by 97%, 86% and 75% of Principals. Respondents also reported very high levels of understanding of Smart Choices and engagement of the school community.Conclusions:The results demonstrated that food supply interventions to promote nutrition across all domains of the school environment can be implemented successfully. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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4. Hepatitis B genotypes in Aboriginal and Torres Strait Islander Australians: correlation with clinical course and implications for management.
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Hanson J, Radlof S, Littlejohn M, Hempenstall A, Edwards R, Nakata Y, Gregson S, Hayes R, Smith S, McKinnon M, Binks P, Tong SYC, Davies J, and Davis JS
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- Adult, Humans, Australia epidemiology, Australian Aboriginal and Torres Strait Islander Peoples, Disease Progression, Genotype, Queensland, Middle Aged, Aged, Australasian People, Carcinoma, Hepatocellular, Hepatitis B, Liver Neoplasms
- Abstract
Background: The prevalence of chronic hepatitis B (CHB) in Aboriginal and Torres Strait Islander Australians in Far North Queensland (FNQ) is greater than twice that of the general Australian population. CHB is common in Torres Strait Islanders diagnosed with hepatocellular carcinoma (HCC) - and in Aboriginals with HCC living in the Northern Territory - however, Aboriginals diagnosed with HCC in FNQ very rarely have CHB. The explanation for this apparent disparity is uncertain., Aims: To determine the HBV genotypes in the FNQ Aboriginal and Torres Strait Islander population and their correlation with clinical phenotype., Methods: We determined the HBV genotype of Aboriginal and Torres Strait Islander Australians living with CHB in FNQ and correlated this with demographic and clinical findings., Results: 134/197 (68%) enrolled individuals had a sufficient viral load for genotyping. All 40 people with HBV/D genotype had Aboriginal heritage, whereas 85/93 (91%) with HBV/C had Torres Strait Islander heritage (P < 0.0001). Individuals with HBV/D were younger than those with HBV/C (median (interquartile range) age: 43 (39-48) vs 53 (42-66) years, P = 0.0002). However, they were less likely to be HBeAg positive (1/40 (3%) vs 23/93 (25%), P = 0.001). All three HCCs developed in Torres Strait Islanders; two-thirds were infected with HBV/C14; genotyping was not possible in the other individual. All 10 diagnoses of cirrhosis occurred in Torres Strait Islanders, 6/10 were infected with HBV/C14, genotyping was not possible in the other four individuals., Conclusions: HBV genotypes in Aboriginal and Torres Strait Islander Australians in FNQ differ markedly, which could explain the significant differences in the clinical phenotype in the two populations and might be used to inform cost-effective CHB care in the region., (© 2023 The Authors. Internal Medicine Journal published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Physicians.)
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- 2024
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5. Molecular epidemiology of hepatitis B among Indigenous Australians in Queensland and the Torres Strait Islands.
- Author
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Littlejohn M, Jaskowski LA, Edwards R, Jackson K, Yuen L, Crawford D, Locarnini SA, and Cooksley G
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- Humans, Australia epidemiology, Molecular Epidemiology, Queensland epidemiology, Hepatitis B, Chronic epidemiology, Australian Aboriginal and Torres Strait Islander Peoples
- Abstract
Background: Chronic hepatitis B virus (HBV) infection is a major health problem for all Indigenous Australians. Post-2000, Hepatitis B surface antigen prevalence has decreased, although remaining four times higher among Indigenous compared with non-Indigenous people., Aims: This study aimed to characterise the HBV from Indigenous populations in Queensland and the Torres Strait Islands., Methods: Serum samples were collected, with consent, from people within Queensland Indigenous communities prior to 1990 as part of the Queensland Health vaccination programme. Ethics approval was subsequently obtained to further characterise the HBV from 93 of these stored samples. HBV DNA was extracted and genotype was obtained from 82 samples. HBV full genome sequencing was carried out for a subset of 14 samples., Results: Seventy-eight samples were identified as genotype C (2 × C12, 3 × C13 and 73 × C14), one sample as genotype A (A2) and three samples as genotype D (1 × D2, 1 × D3 and 1 × D4). The HBV/C sequences identified were most closely related to sequences isolated from Papua New Guinea and Indonesia (Papua Province)., Conclusions: The HBV isolated from the Torres Strait Islanders was notably different to the HBV/C4 strain isolated from Indigenous people of mainland northern Australia, with no evidence of recombination. This reflects the differences in culture and origin between Torres Strait Islanders and mainland Indigenous people., (© 2023 The Authors. Internal Medicine Journal published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Physicians.)
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- 2024
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6. Mortality inequality, spatial differences and health care access.
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Atalay K, Edwards R, and Georgiakakis F
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- Male, Middle Aged, Humans, Female, Young Adult, Adult, Australia epidemiology, Health Services Accessibility, Rural Population, Socioeconomic Factors, Mortality, Longevity, Life Expectancy
- Abstract
Although Australia maintains relatively high standards of health and healthcare, there exists disparity in health outcomes and longevity among different segments of the population. Internationally, there is growing evidence that life expectancy gains are not being shared equally among the rich and the poor. In this paper we examine the evolution of mortality inequality in Australia between 2001 and 2018. Using a spatial inequality model and combining data from several administrative data sources, we document significant mortality inequality between the rich and the poor in Australia. For most age groups, mortality inequality has remained unchanged over the last 20 years. However, mortality inequality is increasing for middle-aged men and women. In part, this can be explained by improvements in longevity which favor urban over rural Australians. Another contributing factor we identify is differential access to healthcare in rich and poor regions. Although Australia's socioeconomic gradient of mortality is flatter than in the US, due to universal health coverage, the fact that mortality inequality is increasing for some groups accentuates the importance of safeguarding health care accessibility., (© 2023 The Authors. Health Economics published by John Wiley & Sons Ltd.)
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- 2023
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7. Australia tightens its prescription-only regulation of e-cigarettes.
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Cohen JE, Gartner C, Edwards R, and Hammond D
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- Humans, Australia, Smoking, Electronic Nicotine Delivery Systems
- Abstract
Competing Interests: Competing interests: The BMJ has judged that there are no disqualifying financial ties to commercial companies. The authors declare the following other interests: DH has testified as a paid expert witness on behalf of public health authorities in response to legal challenges from tobacco, vaping, and cannabis companies. Further details of The BMJ policy on financial interests are here: https://www.bmj.com/sites/default/files/attachments/resources/2016/03/16-current-bmj-education-coi-form.pdf.
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- 2023
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8. Antiphase response of the Indonesian-Australian monsoon to millennial-scale events of the last glacial period.
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Scroxton N, Gagan MK, Ayliffe LK, Hantoro WS, Hellstrom JC, Cheng H, Edwards RL, Zhao JX, Suwargadi BW, and Rifai H
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- Temperature, Indonesia, Australia, Seasons, Cyclonic Storms
- Abstract
Antiphase behaviour of monsoon systems in alternate hemispheres is well established at yearly and orbital scales in response to alternating sensible heating of continental landmasses. At intermediate timescales without a sensible heating mechanism both in-phase and antiphase behaviours of northern and southern hemisphere monsoon systems are recorded at different places and timescales. At present, there is no continuous, high resolution, precisely dated record of millennial-scale variability of the Indonesian-Australian monsoon during the last glacial period with which to test theories of paleomonsoon behaviour. Here, we present an extension of the Liang Luar, Flores, speleothem δ
18 O record of past changes in southern hemisphere summer monsoon intensity back to 55.7 kyr BP. Negative δ18 O excursions (stronger monsoon) occur during Heinrich events whereas positive excursions (weaker monsoon) occur during Dansgaard-Oeschger interstadials-a first order antiphase relationship with northern hemisphere summer monsoon records. An association of negative δ18 O excursions with speleothem growth phases in Liang Luar suggests that these stronger monsoons are related to higher rainfall amounts. However, the response to millennial-scale variability is inconsistent, including a particularly weak response to Heinrich event 3. We suggest that additional drivers such as underlying orbital-scale variability and drip hydrology influence the δ18 O response., (© 2022. The Author(s).)- Published
- 2022
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9. Lives saved during economic downturns: Evidence from Australia.
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Atalay K, Edwards R, Schurer S, and Ubilava D
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- Australia epidemiology, Humans, Male, Mortality, Public Health, Economic Recession, Unemployment
- Abstract
Worldwide, countries have been restricting work and social activities to counter the emerging public health crisis due to the coronavirus pandemic. These measures have caused dramatic increases in unemployment. Some commentators argue that the "draconian measures" will do more harm than good due to the economic contraction, despite a large literature that finds mortality rates decline during recessions. We estimate the relationship between unemployment, a proxy for economic climate, and mortality in Australia, a country with universal health care. Using administrative time-series data on mortality by state, age, sex, and cause of death for 1979-2017, we find no relationship between unemployment and mortality on average. However, we observe beneficial health effects in economic downturns for young men, associated with a reduction in transport accidents. Our estimates imply 431 fewer deaths in 2020 if unemployment rates double as forecast. For the early 1980s, we find a procyclical pattern in infant mortality rates. However, this pattern disappears starting from the mid-1980s, coincident with the 1984 implementation of universal health care. Our results suggest that universal health care may insulate individuals from the health effects of macroeconomic fluctuations., (© 2021 John Wiley & Sons Ltd.)
- Published
- 2021
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10. Prevention of occlusion of cEnTral lInes for children with cancer: An implementation study.
- Author
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Ullman AJ, Condon P, Edwards R, Gibson V, Takashima M, Schults J, Dean A, Cattanach P, Nicholls W, Osborne S, Rickard CM, Cooke M, and Kleidon T
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- Australia epidemiology, Child, Humans, Incidence, Risk Factors, Catheterization, Central Venous adverse effects, Central Venous Catheters adverse effects, Neoplasms epidemiology
- Abstract
Aim: Central venous access devices (CVADs) are vital medical devices to support the treatment of paediatric cancer; however, device occlusion is common, which disrupts treatment. This study aimed to improve the identification and management of CVAD occlusions in children with cancer, as well as to identify the demographic, clinical and device characteristics associated with increased risk for CVAD occlusion., Methods: A pre-post-implementation study was conducted at a metropolitan paediatric oncology facility in Australia, using the Theoretical Domains Framework. Patients with a CVAD for anti-cancer therapy were prospectively followed for occlusive events pre- and post- the implementation of clinical resources to support the identification and management of CVAD occlusive events. CVAD occlusion and management data were collected and compared pre- and post-implementation. Risk factors for CVAD occlusion were described by mixed-effects Poisson regression and incident rate ratios (IRR)., Results: A total of 133 CVADs were inserted into 131 patients for a total of 6784 catheter days. The incidence of CVAD-related occlusion pre-implementation was 59.7 (95% confidence interval (CI) 51.4-69.0, per 1000 catheter days); compared to 31.6 (95% CI 26.4-37.6); P < 0.01) post-implementation of clinical resources. In multivariate models, other than post-implementation phases (IRR 0.51 (95% CI 0.32-0.81)), only neutropaenia significantly increased the risk of CVAD occlusion (IRR 2.14 (95% CI 1.15-3.97))., Conclusion: CVAD occlusions in paediatric oncology are common. The development and implementation of CVAD occlusion resources to guide the identification and management of occlusive episodes led to a significant decrease in occlusive events., (© 2020 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).)
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- 2020
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11. Addressing the barriers to optimal management of febrile neutropenia in children with cancer.
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Anderson K, Bradford N, Edwards R, Nicholson J, Lockwood L, and Clark J
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- Adolescent, Adult, Australia, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Anti-Bacterial Agents administration & dosage, Disease Management, Febrile Neutropenia drug therapy, Neoplasms complications, Parents psychology, Time-to-Treatment statistics & numerical data
- Abstract
Purpose: Fever and associated neutropenia presentations are frequent occurrences for children with cancer. Prompt treatment is required to prevent adverse outcomes; however, delays are common. In Australia's vast landscape, presentations occur in both tertiary metropolitan sites and smaller regional sites. Management and experiences differ between sites. Our primary aim was to identify the barriers to optimal management of febrile neutropenia in children with cancer from patient/parent and clinician perspectives., Methods: A mixed methods approach was used where quantitative data was supplemented by qualitative data. Data were prospectively collected from parents (n=81) and clinicians (n=42) about all children who presented with fever across multiple diverse hospital locations. A subset of parents (n=9) and clinicians (n=19) completed semi-structured interviews., Results: Delays in assessment and treatment were reported by 31% of parents and up to 36% of clinicians. Four distinct time points where delays occurred were identified: 1) pre-presentation; 2) initial assessment; 3) blood collection and establishing intravenous access, and 4) preparation and administration of antibiotics. Although reasons for delay were diverse, they were primarily related to clinician's knowledge and awareness of fever management, and intravenous access device factors. Interventions were formulated to target these barriers and streamline processes., Conclusion: We identified multifactorial reasons for delays at different time points in care. Regional centres and families have unique needs which require considerations and tailored interventions. Ongoing education, monitoring compliance with initiation of practice changes and identifying and overcoming barriers as they arise are strategies for improving management of the febrile child with cancer., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
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- 2020
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12. Prevalence of awareness, ever-use and current use of nicotine vaping products (NVPs) among adult current smokers and ex-smokers in 14 countries with differing regulations on sales and marketing of NVPs: cross-sectional findings from the ITC Project.
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Gravely S, Driezen P, Ouimet J, Quah ACK, Cummings KM, Thompson ME, Boudreau C, Hammond D, McNeill A, Borland R, Thrasher JF, Edwards R, Omar M, Hitchman SC, Yong HH, Barrientos-Gutierrez T, Willemsen MC, Bianco E, Boado M, Goma FM, Seo HG, Nargis N, Jiang Y, Perez CA, and Fong GT
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- Adult, Australia epidemiology, Bangladesh epidemiology, Brazil epidemiology, Canada epidemiology, China epidemiology, Cross-Sectional Studies, England epidemiology, Female, Humans, Logistic Models, Malaysia epidemiology, Male, Marketing legislation & jurisprudence, Mexico epidemiology, Middle Aged, Netherlands epidemiology, New Zealand epidemiology, Prevalence, Republic of Korea epidemiology, United States epidemiology, Uruguay epidemiology, Zambia epidemiology, Commerce legislation & jurisprudence, Electronic Nicotine Delivery Systems, Ex-Smokers statistics & numerical data, Health Knowledge, Attitudes, Practice, Public Policy legislation & jurisprudence, Smokers statistics & numerical data, Vaping epidemiology
- Abstract
Aims: This paper presents updated prevalence estimates of awareness, ever-use, and current use of nicotine vaping products (NVPs) from 14 International Tobacco Control Policy Evaluation Project (ITC Project) countries that have varying regulations governing NVP sales and marketing., Design, Setting, Participants and Measurements: A cross-sectional analysis of adult (≥ 18 years) current smokers and ex-smokers from 14 countries participating in the ITC Project. Data from the most recent survey questionnaire for each country were included, which spanned the period 2013-17. Countries were categorized into four groups based on regulations governing NVP sales and marketing (allowable or not), and level of enforcement (strict or weak where NVPs are not permitted to be sold): (1) most restrictive policies (MRPs), not legal to be sold or marketed with strict enforcement: Australia, Brazil, Uruguay; (2) restrictive policies (RPs), not approved for sale or marketing with weak enforcement: Canada, Malaysia, Mexico, New Zealand; (3) less restrictive policies (LRPs), legal to be sold and marketed with regulations: England, the Netherlands, Republic of Korea, United States; and (4) no regulatory policies (NRPs), Bangladesh, China, Zambia. Countries were also grouped by World Bank Income Classifications. Country-specific weighted logistic regression models estimated adjusted NVP prevalence estimates for: awareness, ever/current use, and frequency of use (daily versus non-daily)., Findings: NVP awareness and use were lowest in NRP countries. Generally, ever- and current use of NVPs were lower in MRP countries (ever-use = 7.1-48.9%; current use = 0.3-3.5%) relative to LRP countries (ever-use = 38.9-66.6%; current use = 5.5-17.2%) and RP countries (ever-use = 10.0-62.4%; current use = 1.4-15.5%). NVP use was highest among high-income countries, followed by upper-middle-income countries, and then by lower-middle-income countries., Conclusions: With a few exceptions, awareness and use of nicotine vaping products varied by the strength of national regulations governing nicotine vaping product sales/marketing, and by country income. In countries with no regulatory policies, use rates were very low, suggesting that there was little availability, marketing and/or interest in nicotine vaping products in these countries where smoking populations are predominantly poorer. The higher awareness and use of nicotine vaping products in high income countries with moderately (e.g. Canada, New Zealand) and less (e.g. England, United States) restrictive policies, is likely due to the greater availability and affordability of nicotine vaping products., (© 2019 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.)
- Published
- 2019
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13. Radiological appearance of coal mine dust lung diseases in Australian workers.
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McBean R, Newbigin K, Dickinson S, and Edwards R
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- Australia, Humans, Male, Anthracosis diagnostic imaging, Tomography, X-Ray Computed
- Abstract
Coal Mine Dust Lung Disease (CMDLD) encompasses a spectrum of lung diseases caused by prolonged exposure to coal mine dust. This review presents high-resolution computed tomography (HRCT) images from men diagnosed with a CMDLD since the resurgence of these diseases in Queensland in 2015., (© 2018 The Royal Australian and New Zealand College of Radiologists.)
- Published
- 2018
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14. Molecular characterization of hepatitis B virus (HBV) in African children living in Australia identifies genotypes and variants associated with poor clinical outcome.
- Author
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Bannister EG, Yuen L, Littlejohn M, Edwards R, Sozzi V, Colledge D, Li X, Locarnini S, Hardikar W, and Revill PA
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- Adolescent, Africa epidemiology, Australia epidemiology, Child, Child, Preschool, Female, Genome, Viral, Humans, Male, Mutation, Phylogeny, Promoter Regions, Genetic genetics, Serogroup, Hepatitis B epidemiology, Hepatitis B virology, Hepatitis B virus genetics
- Abstract
Migration from sub-Saharan Africa is contributing to the rising incidence of chronic hepatitis B (CHB) infection and its complications in Australia. African CHB is associated with unique genotypes, such as E and A1, which are associated with reduced vaccine efficacy and early-onset hepatocellular carcinoma, respectively, although the prevalence of these genotypes outside Africa is poorly described. Treatment-naïve children of African origin with CHB were recruited at the Royal Children's Hospital Melbourne. Population-based sequencing of the complete HBV genome, or the clinically relevant basal core promoter (BCP)/precore (PC) region, was performed, and the HBV genotype/subgenotype assigned by phylogenetic analysis. HBV was characterized in serum from 67 children, median age 12.5 years. HBV genotype E was most frequent (70 %), with genotype D [25 %; subgenotypes D6 (formerly D7)/D3/D2)] and subgenotype A1 (5 %) also being identified. Despite their young age, over 50 % of the children were HBeAg-negative and had seroconverted to anti-HBe, with this being associated with canonical BCP/PC mutations in the majority of cases. The profile of HBV in African children living in Australia was characterized by early HBeAg seroconversion and infection with HBV variants associated with poor clinical outcome, as well as genotypes previously associated with reduced vaccine efficacy or rapid progression to liver cancer. These findings have important ramifications for patient monitoring and treatment guidelines in the Australian paediatric setting.
- Published
- 2018
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15. Molecular virology of hepatitis B virus, sub-genotype C4 in northern Australian Indigenous populations.
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Littlejohn M, Davies J, Yuen L, Edwards R, Sozzi T, Jackson K, Cowie B, Tong S, Davis J, and Locarnini S
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- Amino Acid Sequence, Australia epidemiology, Base Sequence, Carcinoma, Hepatocellular genetics, Carcinoma, Hepatocellular virology, DNA Mutational Analysis, DNA, Viral genetics, Genetic Variation, Genotype, Hepatitis B e Antigens immunology, Hepatitis B virus classification, Hepatitis B, Chronic virology, Humans, Liver Neoplasms genetics, Liver Neoplasms virology, Molecular Sequence Data, Mutation, Phylogeography, Population Groups, Sequence Alignment, Sequence Analysis, DNA, Genome, Viral genetics, Hepatitis B virus genetics, Hepatitis B, Chronic blood, Hepatitis B, Chronic epidemiology
- Abstract
Indigenous Australians experience a significant health burden from chronic hepatitis B infection; however, the strain of hepatitis B virus (HBV) found among Indigenous Australians has not been well characterized. Blood samples were collected from 65 Indigenous Australians with chronic HBV infection from across the Top End of Australia's Northern Territory. Phylogenetic analysis of HBV from these samples revealed that 100% of the isolates were genotype C, sub-genotype C4, expressing the serotype ayw3. This strain is a divergent group within the HBV/C genotype, and has only been described in Indigenous Australians. Evidence of recombination was suggested by discordant phylogenetic clustering of the C4 sequences when comparing the full genome to the surface region and confirmed by recombination analysis which showed the surface gene region to be most closely related to genotype J, while the remaining regions of the genome were most similar to genotype C sequences. Mutational analysis revealed the presence of multiple mutations that have been linked with more rapid liver disease progression and an increased risk of hepatocellular carcinoma. These mutations were detected in the majority of sequences examined. Variants associated with vaccine failure were detected as the predominant viral quasi-species in 3/35 samples. In summary, the HBV C4 variant found in this population has a high potential to cause advanced liver disease and to escape vaccination programs. Further in vitro functional and natural history studies are warranted in order to determine the clinical and public health consequences of infection with the HBV C4 variant in these communities., (© 2014 Wiley Periodicals, Inc.)
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- 2014
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16. Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium.
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Kelemen LE, Bandera EV, Terry KL, Rossing MA, Brinton LA, Doherty JA, Ness RB, Kjaer SK, Chang-Claude J, Köbel M, Lurie G, Thompson PJ, Carney ME, Moysich K, Edwards R, Bunker C, Jensen A, Høgdall E, Cramer DW, Vitonis AF, Olson SH, King M, Chandran U, Lissowska J, Garcia-Closas M, Yang H, Webb PM, Schildkraut JM, Goodman MT, and Risch HA
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- Alcohol Drinking adverse effects, Alcoholic Beverages adverse effects, Australia epidemiology, Canada epidemiology, Carcinoma pathology, Case-Control Studies, Europe epidemiology, Female, Humans, Incidence, Logistic Models, Multivariate Analysis, Odds Ratio, Ovarian Neoplasms pathology, Risk Assessment, Risk Factors, United States epidemiology, Alcohol Drinking epidemiology, Carcinoma epidemiology, Ovarian Neoplasms epidemiology
- Abstract
Background: Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations., Methods: We pooled data from 12 case-control studies in the Ovarian Cancer Association Consortium comprising 5,342 OC cases, 1,455 borderline tumors and 10,358 controls with quantitative information on recent alcohol intake to estimate odds ratios (OR) and 95% confidence intervals (CI) according to frequencies of average daily intakes of beer, wine, liquor and total alcohol., Results: Total alcohol intake was not associated with all OC: consumption of >3 drinks per day compared to none, OR=0.92, 95% CI=0.76-1.10, P trend=0.27. Among beverage types, a statistically non-significant decreased risk was observed among women who consumed >8 oz/d of wine compared to none (OR=0.83, 95% CI=0.68-1.01, P trend=0.08). This association was more apparent among women with clear cell OC (OR, 0.43; 95% CI, 0.22-0.83; P trend=0.02), although based on only 10 cases and not statistically different from the other histologic types (P value for statistical heterogeneity between histologic types = 0.09). Statistical heterogeneity of the alcohol- and wine-OC associations was seen among three European studies, but not among eight North American studies. No statistically significant associations were observed in separate analyses evaluating risk with borderline tumors of serous or mucinous histology. Smoking status did not significantly modify any of the associations., Conclusions: We found no evidence that recent moderate alcohol drinking is associated with increased risk for overall OC, or that variation in risk is associated strongly with specific histologic types. Understanding modifiable causes of these elusive and deadly cancers remains a priority for the research community.
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- 2013
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17. Enabling self-determination for older workers with intellectual disabilities in supported employment in Australia.
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McDermott S and Edwards R
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- Aged, Australia, Decision Making, Female, Humans, Male, Middle Aged, Problem Solving, Retirement, Employment, Supported, Intellectual Disability, Personal Autonomy
- Abstract
Background: Promoting self-determination is recognized to be an essential element of disability service provision; however, the extent to which older people with intellectual disability working in supported employment are enabled to make intentional decisions about retirement is not well understood., Methods: This research explored the views of older people with disability and service providers to understand the elements that impact on people's decision to retire. Seventy-six people participated in semi-structured interviews, including 33 older people with intellectual disability working in supported employment, 10 people who had retired and 30 service providers., Results: Service providers strongly supported the right of people to retire; however, people with disability almost never reported the ability to make self-determined choices about retirement. Barriers to self-determination included an association between retirement, poor health and meaningless activities, which was perpetuated through structural service gaps., Conclusion: Although disability services and service providers emphasize the importance of promoting self-determination for people with disability, those working in supported employment are not currently enabled to make self-directed choices about retirement. To address this requires more flexible services, better information about retirement, exposure to real experiences and assistance to express preferences and participate in problem solving throughout the lifespan., (© 2012 Blackwell Publishing Ltd.)
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- 2012
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18. Availability and marketing of food and beverages to children through sports settings: a systematic review.
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Carter MA, Edwards R, Signal L, and Hoek J
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- Advertising legislation & jurisprudence, Australia, Canada, Child, Choice Behavior, Diet, England, Health Knowledge, Attitudes, Practice, Humans, New Zealand, Television statistics & numerical data, United States, Advertising statistics & numerical data, Beverages, Feeding Behavior, Food Industry statistics & numerical data, Health Promotion, Sports
- Abstract
Objective: The current systematic review aimed to identify and critically appraise research on food environments in sports settings, including research into the types of food and beverages available, the extent and impact of food and beverage sponsorship and marketing, and views about food environments among key stakeholders., Design: A systematic review. Fourteen English-language studies (two were papers describing different facets of the same study), published between 1985 and 2011, were identified from searches of electronic databases and bibliographies of primary studies., Setting: Most studies originated from Australia (n 10), with the remaining studies originating in the UK (n 1), New Zealand (n 1), the USA (n 1) and Canada (n 1). Data were collected from observations in stadia, websites and televised sports events, through in-depth interviews, focus groups and surveys with sports club members, parents and quick serve restaurant managers., Results: Literature exploring food environments in sports settings was limited and had some important methodological limitations. No studies comprehensively described foods available at clubs or stadia, and only one explored the association between food and beverage sponsorship and club incomes. Club policies focused on the impact of health promotion funding rather than the impact of sponsorship or food availability in sports settings., Conclusions: Further research, including comprehensive studies of the food environment in sports settings, is required to document the availability, sponsorship and marketing of food and beverages at national, regional and club levels and to estimate how sports settings may influence children's diets.
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- 2012
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19. The chronic obstructive pulmonary disease strategy.
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Burdon J and Edwards R
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- Australia epidemiology, Combined Modality Therapy, Drug Therapy, Combination, Female, Humans, Male, Pulmonary Disease, Chronic Obstructive epidemiology, Respiratory Therapy methods, Severity of Illness Index, Survival Rate, National Health Programs organization & administration, Pulmonary Disease, Chronic Obstructive therapy
- Published
- 2002
20. Individuals from North America, Australasia, and Africa are infected with four different genotypes of human herpesvirus 8.
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Meng YX, Spira TJ, Bhat GJ, Birch CJ, Druce JD, Edlin BR, Edwards R, Gunthel C, Newton R, Stamey FR, Wood C, and Pellett PE
- Subjects
- Africa, Amino Acid Sequence, Asia, Australia, DNA Fingerprinting, DNA, Viral chemistry, DNA, Viral genetics, Genotype, HIV Infections virology, Herpesvirus 8, Human genetics, Humans, Molecular Sequence Data, Phylogeny, Sequence Analysis, DNA, United States, Viral Envelope Proteins genetics, Viral Proteins genetics, AIDS-Related Opportunistic Infections virology, Herpesviridae Infections virology, Herpesvirus 8, Human classification, Lymphoma, AIDS-Related virology, Sarcoma, Kaposi virology
- Abstract
To study human herpesvirus 8 (HHV-8) transmission between individuals and in populations, we developed a system for genetic fingerprinting of HHV-8 strains based on variation in the HHV-8 K1, glycoprotein B (gB), and glycoprotein H (gH) genes. Using this system, we sequenced nearly the entire K1 gene (840 bp); two segments of the gB gene (open reading frame 8), totaling 813 bp; and a 702-bp segment of the gH gene (open reading frame 22) from blood and tissue samples obtained from 40 human immunodeficiency virus-infected and noninfected individuals, including those with Kaposi's sarcoma, primary effusion lymphoma, or Castleman's disease. The specimen collection was assembled from individuals living in diverse geographical locations, including the United States, Australia, New Zealand, Uganda, and Zambia. As reported by others, K1 was the most variable gene, with up to 16% variation at the nucleotide sequence level and up to 32% variation at the amino acid sequence level. Despite this extensive sequence variation, the K1 amino acid sequence contained 14 conserved cysteine sites, suggesting a conserved tertiary structure. gB and gH sequences were highly conserved, in most cases differing by <0.6% in pairwise comparisons. K1 was the most useful gene for strain discrimination, but the other genes enabled the discrimination of strains with identical K1 sequences. Individuals from diverse geographic locations were infected with four different HHV-8 genotypes; strains did not strictly segregate by continent of origin. The majority of HHV-8 strains from the United States and Europe were relatively closely related, whereas some strains identified from Uganda and Australia were phylogenetically distant. Genotype I strains were the most common and were found on three continents. Identical sequences were found in specimens obtained from different body sites and at different times from the same individual., (Copyright 1999 Academic Press.)
- Published
- 1999
- Full Text
- View/download PDF
21. Molecular method for typing Mycobacterium ulcerans.
- Author
-
Jackson K, Edwards R, Leslie DE, and Hayman J
- Subjects
- Australia epidemiology, DNA, Bacterial analysis, Humans, Molecular Probe Techniques, Mycobacterium Infections, Nontuberculous epidemiology, Nontuberculous Mycobacteria genetics, Nontuberculous Mycobacteria isolation & purification, Polymorphism, Restriction Fragment Length, Bacterial Typing Techniques, Mycobacterium Infections, Nontuberculous microbiology, Nontuberculous Mycobacteria classification
- Abstract
A cluster of Mycobacterium ulcerans infections has recently occurred on Phillip Island, Victoria, Australia. Previous cases of infection have generally been located around Bairnsdale in southeast Gippsland. The aim of this study was to determine the epidemiological relationship between these strains and other strains originating in Australia and Africa. The previously described plasmid pTBN12 was used as a probe with restriction enzyme-digested chromosomal DNA to differentiate the strains of M. ulcerans. The probe was able to distinguish 11 restriction fragment length polymorphisms (RFLPs). Forty-three strains originating in Victoria were divided into three types, i.e., V1, V2, and V3. The majority of strains (40) yielded a type V1 pattern, including strains from southeast Gippsland. Fourteen strains from Queensland yielded three additional RFLP types, i.e., Q1, Q2, and Q3. Five strains from Benin and seven strains from Zaire yielded five additional RFLP types. It is envisaged that molecular typing of M. ulcerans strains from around the world may have a great impact on understanding of the epidemiology of infection with this organism.
- Published
- 1995
- Full Text
- View/download PDF
22. An evaluation of multiphasic screening on admission to hospital. Precis of a report to the National Health and Medical Research Council.
- Author
-
Durbridge TC, Edwards F, Edwards RG, and Atkinson M
- Subjects
- Australia, Cost-Benefit Analysis, Evaluation Studies as Topic, Humans, Length of Stay, Hospitalization, Hospitals, General, Multiphasic Screening
- Abstract
A controlled study of admission multiphasic screening (AMS) at a large general hospital showed that AMS had no significant effect on a variety of indices of inpatient progress. Owing to a 64% increase in estimated cost of investigations with AMS, the total hospital admission cost was increased by approximately 5%. Under the conditions of this study, AMS added to the cost of hospitalization without associated evidence of benefit to the patient.
- Published
- 1976
23. Evaluation of benefits of screening tests done immediately on admission to hospital.
- Author
-
Durbridge TC, Edwards F, Edwards RG, and Atkinson M
- Subjects
- Australia, Evaluation Studies as Topic, Humans, Time Factors, Chemistry, Clinical, Hospitalization
- Abstract
Evidence was sought of improved inpatient progress and reduced hospital costs when a battery of investigations were done at the time a patient was admitted to hospital. The outcome in 500 admission-tested patients was compared with that in two other groups of 500 control patients. No significant differences were found among the three groups in a variety of indices of inpatient progress. Because of an estimated 64% increase in the cost of investigating inpatients with admission testing, the total cost of hospital care was increased by about 5%. Under the conditions of this study, admission testing added to the cost of hospitalization, without associated evidence of benefit to the patient.
- Published
- 1976
24. A trial of lactose hydrolysed milk in Australian Aboriginal children.
- Author
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Brand JC, Miller JJ, Vorbach EA, and Edwards RA
- Subjects
- Animals, Australia, Body Weight, Child, Preschool, Clinical Trials as Topic, Diarrhea, Female, Humans, Hydrolysis, Infant, Lactose Intolerance diet therapy, Male, Lactose, Milk, Native Hawaiian or Other Pacific Islander
- Abstract
Weight gains in 50 young Australian Aboriginal children were studied in a blind controlled hospital trial of reconstituted, lactose hydrolysed milk powder (test) and full-cream milk powder (control). The mean weight gains (+/- SEM) were 4.80 +/- 0.80 g kg-1 day-1 for children receiving the lactose hydrolysed milk, and 2.20 +/- 0.75 g kg-1 day-1 for those receiving the normal milk P less than 0.0125). Weight gain of infants (that is, those under one year of age) in the control group was less than 10% of that in the test group (P less than 0.0025). Weight gain was higher in children fed hydrolysed milk irrespective of percentage of Standard Weight for Age or the presence or absence of recognizable symptoms of lactose intolerance. Lactose malabsorption appears to be a major factor in the growth retardation of Aboriginal children. It is recommended that lactose hydrolysed milk replace normal milk in the supplementary feeding of Aboriginal infants and children.
- Published
- 1977
- Full Text
- View/download PDF
25. Panel discussion: the potential for primary and secondary prevention in coronary disease.
- Author
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Valentine P, Palmer J, Edwards R, Pole D, and Norris R
- Subjects
- Adult, Australia, Blood Glucose, Child, Cholesterol standards, Coronary Disease blood, Coronary Disease complications, Diet Therapy, Dietary Fats, Fats, Unsaturated, Humans, Hyperlipidemias complications, Male, Margarine, Coronary Disease prevention & control
- Published
- 1973
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