7 results on '"Eaves, Lindon J."'
Search Results
2. Interaction of Marital Status and Genetic Risk for Symptoms of Depression
- Author
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Heath, Andrew C, Eaves, Lindon J, and Martin, Nicholas G
- Published
- 1998
3. Cross-Cultural Comparison of Genetic and Cultural Transmission of Smoking Initiation Using an Extended Twin Kinship Model.
- Author
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Maes, Hermine H., Morley, Kate, Neale, Michael C., Kendler, Kenneth S., Heath, Andrew C., Eaves, Lindon J., and Martin, Nicholas G.
- Subjects
SMOKING ,TWIN psychology ,KINSHIP ,ASSORTATIVE mating ,GENDER differences (Psychology) ,GENE expression ,AGE distribution ,BIOLOGICAL models ,COMPARATIVE studies ,CULTURE ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,RESEARCH funding ,EVALUATION research - Abstract
Background: Considerable evidence from twin and adoption studies indicates that genetic and shared environmental factors play a role in the initiation of smoking behavior. Although twin and adoption designs are powerful to detect genetic and environmental influences, they do not provide information on the processes of assortative mating and parent-offspring transmission and their contribution to the variability explained by genetic and/or environmental factors.Methods: We examined the role of genetic and environmental factors in individual differences for smoking initiation (SI) using an extended kinship design. This design allows the simultaneous testing of additive and non-additive genetic, shared and individual-specific environmental factors, as well as sex differences in the expression of genes and environment in the presence of assortative mating and combined genetic and cultural transmission, while also estimating the regression of the prevalence of SI on age. A dichotomous lifetime 'ever' smoking measure was obtained from twins and relatives in the 'Virginia 30,000' sample and the 'Australian 25,000'.Results: Results demonstrate that both genetic and environmental factors play a significant role in the liability to SI. Major influences on individual differences appeared to be additive genetic and unique environmental effects, with smaller contributions from assortative mating, shared sibling environment, twin environment, cultural transmission, and resulting genotype-environment covariance. Age regression of the prevalence of SI was significant. The finding of negative cultural transmission without dominance led us to investigate more closely two possible mechanisms for the lower parent-offspring correlations compared to the sibling and DZ twin correlations in subsets of the data: (1) age × gene interaction, and (2) social homogamy. Neither of the mechanism provided a significantly better explanation of the data.Conclusions: This study showed significant heritability, partly due to assortment, and significant effects of primarily non-parental shared environment on liability to SI. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
4. A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents.
- Author
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Maes, Hermine H., Prom-Wormley, Elizabeth, Eaves, Lindon J., Soo Hyun Rhee, Hewitt, John K., Susan Young, Corley, Robin, McGue, Matt, Iacono, William G., Legrand, Lisa, Samek, Diana R., Murrelle, E. Lenn, Silberg, Judy L., Miles, Donna R., Schieken, Richard M., Beunen, Gaston P., Thomis, Martine, Rose, Richard J., Dick, Danielle M., and Boomsma, Dorret I.
- Subjects
GENETIC epidemiology ,TEENAGERS ,TOBACCO use ,SMOKING -- Environmental aspects ,SMOKING ,GENETICS ,COMPARATIVE studies ,EPIDEMIOLOGICAL research ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,RESEARCH funding ,TWINS ,EVALUATION research - Abstract
Introduction: Previous studies in adolescents were not adequately powered to accurately disentangle genetic and environmental influences on smoking initiation (SI) across adolescence.Methods: Mega-analysis of pooled genetically informative data on SI was performed, with structural equation modeling, to test equality of prevalence and correlations across cultural backgrounds, and to estimate the significance and effect size of genetic and environmental effects according to the classical twin study, in adolescent male and female twins from same-sex and opposite-sex twin pairs (N = 19 313 pairs) between ages 10 and 19, with 76 358 longitudinal assessments between 1983 and 2007, from 11 population-based twin samples from the United States, Europe, and Australia.Results: Although prevalences differed between samples, twin correlations did not, suggesting similar etiology of SI across developed countries. The estimate of additive genetic contributions to liability of SI increased from approximately 15% to 45% from ages 13 to 19. Correspondingly, shared environmental factors accounted for a substantial proportion of variance in liability to SI at age 13 (70%) and gradually less by age 19 (40%).Conclusions: Both additive genetic and shared environmental factors significantly contribute to variance in SI throughout adolescence. The present study, the largest genetic epidemiological study on SI to date, found consistent results across 11 studies for the etiology of SI. Environmental factors, especially those shared by siblings in a family, primarily influence SI variance in early adolescence, while an increasing role of genetic factors is seen at later ages, which has important implications for prevention strategies.Implications: This is the first study to find evidence of genetic factors in liability to SI at ages as young as 12. It also shows the strongest evidence to date for decay of effects of the shared environment from early adolescence to young adulthood. We found remarkable consistency of twin correlations across studies reflecting similar etiology of liability to initiate smoking across different cultures and time periods. Thus familial factors strongly contribute to individual differences in who starts to smoke with a gradual increase in the impact of genetic factors and a corresponding decrease in that of the shared environment. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
5. Genetic and Environmental Influences on Individual Differences in Attitudes Toward Homosexuality: An Australian Twin Study.
- Author
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Verweij, Karin J. H., Shekar, Sri N., Zietsch, Brendan P., Eaves, Lindon J., Bailey, J. Michael, Boomsma, Dorret I., and Martin, Nicholas G.
- Subjects
GENETICS ,SOCIAL influence ,INDIVIDUAL differences ,ATTITUDE (Psychology) ,HETEROSEXUALS ,HOMOSEXUALITY ,HOMOPHOBIA - Abstract
Previous research has shown that many heterosexuals hold negative attitudes toward homosexuals and homosexuality (homophobia). Although a great deal of research has focused on the profile of homophobic individuals, this research provides little theoretical insight into the aetiology of homophobia. To examine genetic and environmental influences on variation in attitudes toward homophobia, we analysed data from 4,688 twins who completed a questionnaire concerning sexual behaviour and attitudes, including attitudes toward homosexuality. Results show that, in accordance with literature, males have significantly more negative attitudes toward homosexuality than females and non-heterosexuals are less homophobic than heterosexuals. In contrast with some earlier findings, age had no significant effect on the homophobia scores in this study. Genetic modelling showed that variation in homophobia scores could be explained by additive genetic (36%), shared environmental (18%) and unique environmental factors (46%). However, corrections based on previous findings show that the shared environmental estimate may be almost entirely accounted for as extra additive genetic variance arising from assortative mating for homophobic attitudes. The results suggest that variation in attitudes toward homosexuality is substantially inherited, and that social environmental influences are relatively minor. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
6. Further Evidence Against the Environmental Transmission of Individual Differences in Neuroticism from a Collaborative Study of 45,850 Twins and Relatives on Two Continents.
- Author
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Lake, Robert I.E., Eaves, Lindon J., Maes, Hermine H.M., Heath, Andrew C., and Martin, Nicholas G.
- Subjects
- *
NEUROSES , *BEHAVIOR genetics , *TWINS , *ADOPTEES - Abstract
We examine the hypothesis that environmental transmission is a significant factor in individual differences for Neuroticism among 45,850 members of extended twin kinships from Australia (N = 20,945) and the United States (N = 24,905). To this large data set we fitted a model estimating genetic and environmental components of variance and gene-environmental covariance to examine the causes of individual differences in Neuroticism. For the combined sample we reject models including environmental transmission, shared environment, and a special twin environment in favor of more parsimonious genetic models. The best-fitting model involved only modest assortative mating, nonshared environment, and both additive and nonadditive genetic components. We conclude, first, that there is no evidence for environmental transmission as a contribution to individual differences in Neuroticism in these replicated samples, drawn from different continents, and, second, that a simple genetic structure underlies familial resemblance for the personality trait of Neuroticism. It is interesting that, despite the opportunity provided by the elaborate design and extensive power of our study, the picture revealed for the causes of individual differences in Neuroticism is little more complex than that found from earlier, simpler designs applied to smaller samples. However, this simplicity could not have been confirmed without using a highly informative design and a very large sample. [ABSTRACT FROM AUTHOR]
- Published
- 2000
- Full Text
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7. Males do not reduce the fitness of their female co-twins in contemporary samples.
- Author
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Medland SE, Loehlin JC, Willemsen G, Hatemi PK, Keller MC, Boomsma DI, Eaves LJ, and Martin NG
- Subjects
- Aged, Aged, 80 and over, Australia, Female, Humans, Male, Middle Aged, Netherlands, Twins, Dizygotic psychology, Twins, Monozygotic psychology, United States, Fertility physiology, Reproduction physiology, Sex Characteristics, Twins, Dizygotic physiology, Twins, Monozygotic physiology
- Abstract
Lummaa et al. (2007) presented historical data collected from twins born in Finland between 1734 and 1888 which suggested that females (N = 31) born as part of an opposite sex (OS) twin pair were 25% less likely to reproduce than female twins (N = 35) born as part of a same sex (SS) pair. They hypothesized that this reduction in fitness was due to masculinization of the female fetus via prenatal effects of the hormones of a male fetus. Because such masculinization would presumably take place in modern populations as well, it would seem important to establish to what degree it does so, and if so, whether reproduction is affected. We therefore address the question of reproduction differences in individual female twins from same-sex (N = 1979) and opposite-sex (N = 913) dizygotic pairs in studies carried out in Australia, the Netherlands, and the United States. In all three samples, there were no differences in the number of children or age of first pregnancies in women from same sex pairs compared to those from opposite sex pairs. Similarly, there were no differences in psychological femininity between women from pairs of the same or opposite sex.
- Published
- 2008
- Full Text
- View/download PDF
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