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Cosmology presents students with ideas that stimulate their curiosity and brings together various concepts from STEM that call on a variety of reasoning types across multiple representational modes, involving subtleties of spacetime relations, a variety of models and evidence requiring multiple lines of high precision observations. This study investigated high school students' levels and types of reasoning that frame their conceptions in different cosmology topics. An open-ended knowledge survey, the Cosmology Knowledge Survey (CosmoKS), was developed and implemented online to 286 high school students (aged 16-18 years) from Australia and Sweden. A modified version of the Structure of the Observed Learning Outcome (SOLO) taxonomy with four levels (pre-structural, uni-structural, multi-structural and relational) was used as a guide to analyse students' open-ended and structured responses. This provided insights into the level and complexity of reasoning underpinning a variety of conceptions across the four dimensions of cosmology education: size and scale, spacetime location, composition of the universe and evolution of the universe. The study identified underlying patterns in student reasoning and conceptions in cosmology, summarised as (i) navigating spatial and temporal relations, (ii) counterintuitive concepts and (iii) language and everyday experience, especially intuition. The analysis led to the characterisation of a hierarchy of reasoning that helps identify sources of alternative conceptions and provided the basis for the development of a concept inventory and progression with broad implications.

Cosmology concepts encompass complex spatial and temporal relations that are counterintuitive. Cosmology findings, because of their intrinsic interest, are often reported in the public domain with enthusiasm, and students come to cosmology with a range of conceptions some aligned and some at variance with the current science. This makes cosmology concepts challenging to teach, and also challenging to evaluate students' conceptual understanding. This study builds on previous research of the authors investigating the methodological challenges for characterising students' cosmology conceptions and the reasoning underlying these. Insights from student responses in two iterations of an open-ended instrument were used to develop a concept inventory that combined cosmological conceptions with reasoning levels based on the SOLO taxonomy. This paper reports on the development and validation of the Cosmology Concept Inventory (CosmoCI) for high school. CosmoCI is a 28-item multiple-choice instrument that was implemented with grade 10 and 11 school students (n = 234) in Australia and Sweden. Using Rasch analysis in the form of a partial credit model (PCM), the paper describes a validated progression in student reasoning in cosmology across four conceptual dimensions, supporting the utility of CosmoCI as an assessment tool which can also instigate rich discussions in the science classroom.

Education is increasingly being framed by a competence mindset; the value of knowledge lies much more in competence performativity and innovation than in simply knowing. Reaching such competency in areas such as astronomy and physics has long been known to be challenging. The movement from everyday conceptions of the world around us to a disciplinary interpretation is fraught with pitfalls and problems. Thus, what underpins the characteristics of the disciplinary trajectory to competence becomes an important educational consideration. In this article we report on a study involving what students and lecturers discern from the same disciplinary semiotic resource. We use this to propose an Anatomy of Disciplinary Discernment (ADD), a hierarchy of what is focused on and how it is interpreted in an appropriate, disciplinary manner, as an overarching fundamental aspect of disciplinary learning. Students and lecturers in astronomy and physics were asked to describe what they could discern from a video simulation of travel through our Galaxy and beyond. In all, 137 people from nine countries participated. The descriptions were analysed using a hermeneutic interpretive study approach. The analysis resulted in the formulation of five qualitatively different categories of discernment; the ADD, reflecting a view of participants' competence levels. The ADD reveals four increasing levels of disciplinary discernment: Identification, Explanation, Appreciation, and Evaluation. This facilitates the identification of a clear relationship between educational level and the level of disciplinary discernment. The analytical outcomes of the study suggest how teachers of science, after using the ADD to assess the students disciplinary knowledge, may attain new insights into how to create more effective learning environments by explicitly crafting their teaching to support the crossing of boundaries in the ADD model.

Crime script analysis was used to analyze intimate partner violence diversity by identifying variables significantly associated with different script tracks. Qualitative thematic analysis using official police administrative data from Queensland, Australia, was used to develop an intimate partner violence protoscript (n = 40), followed by quantitative hierarchical cluster analysis and cross-tabulations to examine diversity within scripts. Four diverse script tracks were identified: "escalating jealousy," "persistently possessive," "controlling victim agency," and "enduring argument." Intimate partner diversity exists with divisions based on statistically significant variables. Implications for situational crime prevention and the use of mixed methods for strengthening crime script analysis are discussed. [ABSTRACT FROM AUTHOR]

Over the past few decades, a body of research has developed examining the academic dishonesty of university and college students. While research has explored academic dishonesty amongst American criminal justice and policing students, no research has specifically focused on investigating the dynamics and correlates of academic dishonesty amongst Australian criminology students. This study drew upon data obtained from a survey of 79 undergraduate criminal justice and policing students studying at an Australian university. Overall, the results suggest that male gender, viewing academic dishonesty as less serious and holding justifications for engaging in this type of behaviour were significant predictors of self-reported academic dishonesty. The findings suggest that more proactive strategies need to be implemented by universities to prevent student involvement in academic dishonesty.

The death literacy index (DLI) was developed in Australia to measure death literacy, a set of experience-based knowledge needed to understand and act on end-of-life (EOL) care options but has not yet been validated outside its original context. The aim of this study was to develop a culturally adapted Swedish-language version of the DLI, the DLI-S, and assess sources of evidence for its validity in a Swedish context. The study involved a multi-step process of translation and cultural adaptation and two validation phases: examining first content and response process validity through expert review (n = 10) and cognitive interviews (n = 10); and second, internal structure validity of DLI-S data collected from an online cross-sectional survey (n = 503). The psychometric evaluation involved analysis of descriptive statistics on item and scale-level, internal consistency and test-retest reliability, and confirmatory factor analysis. During translation and adaptation, changes were made to adjust items to the Swedish context. Additional adjustments were made following findings from the expert review and cognitive interviews. The content validity index exceeded recommended thresholds (S-CVIAve = 0.926). The psychometric evaluation provided support for DLI-S' validity. The hypothesized six-factor model showed good fit (χ2 = 1107.631 p<0.001, CFI = 0.993, TLI = 0.993, RMSEA = 0.064, SRMR = 0.054). High internal consistency reliability was demonstrated for the overall scale (Cronbach's α = 0.94) and each sub-scale (α 0.81–0.92). Test-retest reliability was acceptable, ICC ranging between 0.66–0.85. Through a comprehensive assessment of several sources of evidence, we show that the DLI-S demonstrates satisfactory validity and acceptability to measure death literacy in the Swedish context. There are, however, indications that the sub-scales measuring community capacity perform worse in comparison to other sca and may function differently in Sweden than in the original context. The DLI-S has potential to contribute to research on community-based EOL interventions. [ABSTRACT FROM AUTHOR]

This article explores how prison staff in Australia view their work and how their work is viewed by others, by applying a theoretical framework of 'dirty work'. 'Dirty work' is a social construction that refers to tasks that are 'physically, socially or morally tainted' (Ashforth and Kreiner, 1999; Hughes, 1958) and this article will apply this concept to prison staff in Australia for the first time. The discussion is based on qualitative research in seven different Australian prisons, ranging from high to low security. The article illustrates how staff responds to working in a 'dirty' profession by reframing, refocusing, and recalibrating their daily work tasks; how the staff uniform can be utilised as a status shield and protector from taint; and how the stigma of 'dirtiness' tends to foster strong occupational and workgroup cultures which in turn makes cultural change of a profession difficult. The consequences of the dirty work stigma for staff and prisoners are discussed, with a focus on informal interactions, case work and dynamic security. [ABSTRACT FROM AUTHOR]

Private investors can help governments overcome budget constraints in infrastructure procurement and to increase the quality of infrastructure assets. However, private investors' engagement can result in inflexibility and high costs for both taxpayers and the users of the infrastructure service. Australia and Canada are forerunners in building successful collaborations with private investors in the infrastructure space. In a three-year project, the authors attempted to get public infrastructure owners still relying on traditional infrastructure procurement to collaborate with institutional investors for the long term. This paper documents the insights received during this journey, providing lessons for countries considering brokering direct investment deals. ABSTRACT Infrastructure projects where many partners and technologies must work together to produce a functioning and sustainable outcome are often challenging. Australia, Canada and UK are among the few countries that have actively been rethinking infrastructure procurement. In these countries, the private sector has been given a bigger share in infrastructure projects, and this trend is spreading to other countries. The authors contribute to the literature by investigating infrastructure owners' and investors' motives and challenges to engage in closer collaboration in a country using traditional procurement methods. They identify problems in building successful collaboration and suggest ways to overcome these challenges. [ABSTRACT FROM AUTHOR]

There is a need for research to identify the impact of mild stroke on occupational engagement. The Occupational Gaps Questionnaire (OGQ) measures the difference between a person's actual and preferred occupational engagement. This study aimed to test the feasibility of the English version of the OGQ, and describe occupational gaps of people with mild stroke. A mixed methods, cross-sectional study involving 10 people with mild stroke at 1 and/or 9 months after stroke. Quantitative data were summarised descriptively and thematic analysis explored qualitative responses. Participants reported a mean of 6.7 (SD 5.1) gaps at 1-month and 3.00 (SD 2.1) gaps at 9-months. Outdoor activities, work, sports, and light home and heavy-duty maintenance were identified as gaps at both time-points. Two themes emerged from the qualitative analysis: Drivers of occupation and Occupations can be challenged or enabled. An additional finding in terms of feasibility was drawn from qualitative data: Feasibility of Conducting the OGQ with people with mild stroke. The English version of the OGQ was found to be a feasible instrument for identifying occupational gaps following mild stroke and may be suitable to support research and clinical practice with this population. [ABSTRACT FROM AUTHOR]

The Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings together data from multiple birth cohorts from across Europe and Australia to facilitate studies on the influence of early-life exposures on later health outcomes. A major product of this collaboration has been the establishment of a FAIR (findable, accessible, interoperable and reusable) data resource known as the EU Child Cohort Network. Here we focus on the EU Child Cohort Network's core variables. These are a set of basic variables, derivable by the majority of participating cohorts and frequently used as covariates or exposures in lifecourse research. First, we describe the process by which the list of core variables was established. Second, we explain the protocol according to which these variables were harmonised in order to make them interoperable. Third, we describe the catalogue developed to ensure that the network's data are findable and reusable. Finally, we describe the core data, including the proportion of variables harmonised by each cohort and the number of children for whom harmonised core data are available. EU Child Cohort Network data will be analysed using a federated analysis platform, removing the need to physically transfer data and thus making the data more accessible to researchers. The network will add value to participating cohorts by increasing statistical power and exposure heterogeneity, as well as facilitating cross-cohort comparisons, cross-validation and replication. Our aim is to motivate other cohorts to join the network and encourage the use of the EU Child Cohort Network by the wider research community. [ABSTRACT FROM AUTHOR]

Background and Aims: Most homicide studies focus upon 'acute' situational intoxication as opposed to 'chronic' substance misuse. The aims of the study were to: (1) determine the extent of homicide offenders' alcohol and drug use in the year preceding the homicide; (2) compare the individual characteristics of homicide offenders across levels of problematic substance use; and (3) compare homicide incident characteristics across levels of problematic substance use. Design and Setting: Observational study using data collected through face‐to‐face interviews in custodial and community correctional settings across Australia. Participants were recruited through an opt‐in process. Participants: The data consist of 302 individuals convicted of murder or manslaughter. Measurements We used the Alcohol Use Disorder Identification Test and Drug Abuse Screening Test to determine problematic alcohol or drug use. We also used a range of self‐report measures to ascertain offender characteristics [socio‐demographics, developmental experiences, criminal history, personality] and incident characteristics (who was killed, and situational intoxication). Findings Of the sample, 38.8% displayed high levels of alcohol problems and 30.8% displayed high levels of drug problems. Those displaying high levels of alcohol and/or drug problems were more likely than those without high levels of alcohol and/or drug problems to report adverse developmental experiences, low education, financial difficulties, extensive criminal histories and high levels of trait anger, impulsivity and risk‐seeking. In addition, offenders with problematic substance use were more likely to have killed non‐family and to have used substances at the time of the homicide. Conclusions: High proportions of homicide offenders in Australia appear to have problematic substance use in the year preceding the homicide offence, and such use appears to be associated with a range of other challenging factors, including adverse childhoods, criminal involvement, low socio‐economic factors and low self‐regulation. [ABSTRACT FROM AUTHOR]

Knowledge of women's pathways to serious offending, including homicide, is limited. This study contributes to a small but growing body of literature examining the criminal careers of serious female offenders by using interview data with females convicted of murder or manslaughter in Australia to examine various dimensions of their criminal careers, specifically, prevalence, frequency, age of onset, duration, and offending variety. In particular, in this study we compared criminal career dimensions across women who had killed a family member (e.g., intimate partner, children) and those whose victims were not part of the family unit (i.e., acquaintances or strangers). Our findings reveal differences between female homicide offenders who kill within and outside of the family unit. Although both groups had comparable overall lifetime prevalence of self-reported participation in criminal offending, findings indicate that participation among the family group was typically at low levels of frequency, of limited duration, and with relatively little variety in categories of offending. The family group also reported lower contact with the criminal justice system compared with the nonfamily group, and were less likely to have experienced some form of criminal/legal sanction in the 12 months prior to the homicide incident. This suggests that women who kill family members are more "conventional" than their nonfamily counterparts, in terms of having low and time-limited (i.e., short duration) lifetime participation in criminal offending. [ABSTRACT FROM AUTHOR]

Homicide-suicide represents one of the rarest forms of lethal violence but often precipitates calls to revise social, health, and justice policies. However, there is little empirical information about this type of violence. The current study uses two unique data sets to examine a wide range of individual and situational characteristics of homicide-suicide, with particular emphasis on establishing whether and how homicide-suicide differs from homicide-only and suicide-only. Findings suggest homicide-suicide may have unique characteristics that set it apart from both homicide-only and suicide-only, as well as sharing certain other characteristics with those two types of events. [ABSTRACT FROM AUTHOR]

Lethal violence is particularly 'newsworthy', and international research suggests that media representations of homicides provide a distorted depiction of the actual nature and risk of homicides. Understanding media portrayals of homicide is important given the impact crime reporting may have on public opinion and policymaking. However, much of the past research has been conducted in the United States and the United Kingdom. Using a sample of Australian newspaper articles published between 1 July 2008 and 30 June 2012, this study focuses on whether media representations of homicide are consistent with the actual characteristics of homicide in Australia (as reported in the National Homicide Monitoring Program (Bryant & Cussen 2015) data). This study revealed mixed findings. Although the reporting in the sample was generally inconsistent with official homicide victim and situational characteristics, the reported offender characteristics were similar to the actual characteristics of offenders in Australia. [ABSTRACT FROM AUTHOR]

Background: Asthma management may involve a step up in treatment when symptoms are not well controlled. We examined whether budesonide/formoterol maintenance and reliever therapy (MRT) is as effective as higher, fixed-dose budesonide plus as-needed terbutaline in patients requiring step-up from Step 2 treatment (low-dose inhaled corticosteroids), stratified by baseline reliever use.Methods: A post-hoc analysis utilized data from three clinical trials of 6-12 months' duration. Patients aged ≥12 years with symptomatic asthma uncontrolled despite Step 2 treatment were included. Severe exacerbation rate, lung function and reliever use were analysed, stratified by baseline reliever use (<1, 1-2 and >2 occasions/day).Results: Overall, 1239 patients were included. Reductions in severe exacerbation rate with budesonide/formoterol MRT versus fixed-dose budesonide were similar across baseline reliever use levels, and were statistically significant in patients using 1-2 (42%, p = 0.01) and >2 (39%, p = 0.02) reliever occasions/day, but not <1 reliever occasion/day (35%, p = 0.11). Both treatments significantly increased mean FEV1 from baseline; improvements were significantly greater for budesonide/formoterol MRT in all reliever use groups. Reductions in reliever use from baseline were significantly greater with budesonide/formoterol MRT versus fixed-dose budesonide in patients using 1-2 and >2 reliever occasions/day (-0.33 and -0.74 occasions/day, respectively).Conclusions: Treatment benefit with budesonide/formoterol MRT versus higher, fixed-dose budesonide plus short-acting β2-agonist was found in Step 2 patients with relatively low reliever use, supporting the proposal that budesonide/formoterol MRT may be useful when asthma is uncontrolled with low-dose inhaled corticosteroid. [ABSTRACT FROM AUTHOR]

Per- and polyfluoroalkyl substances (PFASs) are a family of compounds that includes numerous compound classes. To date, only a subset of these PFASs have been studied thoroughly in the general population. In this study, pooled serum samples from Australia collected in 2002–2013 were analyzed for PFASs according to gender and age (age categories of 0–4 years, 5–15 years, 16–30 years, 31–45 years, 46–60 years, and >60 years), in total 54 pooled samples and 4920 individuals. Compound classes included were perfluorocarboxylic acids (PFCAs), perfluorosulfonic acids (PFSAs), and two groups of PFCA precursor compounds; polyfluoroalkyl phosphate diesters (diPAPs), and fluorotelomer sulfonic acids (FTSAs). Several PFASs that were not reported in previous studies of Australian serum samples were found in this sample set including; diPAPs, FTSAs, perfluoropentane sulfonic acid (PFPeS), perfluoroheptane sulfonic acid (PFHpS), perfluoroheptane carboxylic acid (PFHpA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), and perfluorotridecanoic acid (PFTrDA). Various temporal trends were observed with a significant reduction (p < 0.05) between 2002 and 2013 for 8:2 FTSA, perflurohexane sulfonic acid (PFHxS), PFHpS, PFOS, and perflurooctanoic acid (PFOA). Levels of longer-chained PFDA and PFUnDA started to decrease more recently, between 2006 and 2013, while PFDoDA increased during the same time period. Higher levels in younger age groups (0–4 and 5–15 years) compared to adults (>15 years) were found for 8:2 FTSA and PFHpA, while levels of PFHpS, PFOS, PFUnDA, PFDoDA and PFTrDA were higher in adult age groups compared to younger age groups. Gender-specific patterns were seen for PFOA, PFHxS, PFHpS and PFOS, where levels were lower in women. Changes in manufacturing processes were reflected in the temporal time trends, and differences in bioaccumulation potential between homologues could be associated with age trends. Our results emphasize the importance of including emerging classes of PFASs in biomonitoring studies. [ABSTRACT FROM AUTHOR]

Public-private partnership (PPP) concession agreements are awarded by National, State and local public agencies that contract with private companies to finance and deliver infrastructure as a long term service to governments and their citizens, rather than having the private firms design and build infrastructure assets to be financed, operated-and, hopefully, maintained-by government. PPPs are similar to the emerging model of selling business or personal software as a cloud-based service (SaaS) rather than as a product licensed by the user-a model that that has transformed and disrupted the enterprise software industry. Australia is a world leader in PPP infrastructure delivery, and has had over two decades of experience in delivering civil and social infrastructure services to its citizens via PPP concessions. Along the way, the public and private participants in infrastructure PPPs have developed practices and a mature institutional framework necessary for this kind of long-term, risky public-private commercial partnership. This study reports the findings from in-depth interviews with 25 senior executives of public and private participants in PPP infrastructure projects from the three Eastern Australian States with the longest history of PPP delivery. Based on the results of those interviews, we develop a governance model for infrastructure service delivery: the government selects infrastructure projects, guided by a non-partisan, expert infrastructure prioritization panel, and contracts for the delivery of these prioritized infrastructure services with a private concessionaire financed by long-term institutional investment capital. The concessionaire is a private entity in charge of financing, designing, constructing, operating, and maintaining the infrastructure service. The government supervises the infrastructure service, to safeguard public interest. The government also provides an institutional framework, with contracts and authorities necessary for the interaction between the public and private actors. [ABSTRACT FROM AUTHOR]

Data drawn from the Australian Homicide Project were used to examine whether and how maternal and paternal filicide perpetrators differ in terms of motivations for filicide and childhood and adulthood adversities. In addition, key differences between filicide and non-filicide perpetrators were examined. Data were collected across a number of states and territories in Australia between 2010 and 2013 through interviews with 231 men and women convicted of murder or manslaughter. Of these participants, 14 had perpetrated filicide. Detailed information on the developmental background of the perpetrators, as well as motives and situational contexts of the homicide incidents, was gathered through the interviews. Findings from the current study reveal some important gender differences among filicide perpetrators. For example, filicidal fathers are more likely to perpetrate accidental filicide, and to report unemployment, alcohol and drug problems and previous engagement in child abuse, while filicidal mothers are more likely to perpetrate altruistic or neglectful filicide, and to report mental health problems. In addition, male filicide perpetrators report a greater number of adversities compared to male non-filicide perpetrators, while female filicide perpetrators display fewer adversities compared to their non-filicide counterparts. Key Practitioner Messages Practitioners are uniquely placed to assist in filicide prevention., Opportunities for service providers to raise awareness of key risk factors for filicide are crucial., Health and social service providers are ideally placed to screen parents seeking support to uncover early warning risks., Mental health service support is crucial, particularly for mothers, as is screening parents for severe depression or suicidal ideations., Provision of parenting support skills to help parents cope with extreme stress appears salient. [ABSTRACT FROM AUTHOR]

Tropical sea cucumber fisheries follow a predictable pattern of serial depletion. Overfishing is exacerbated in developing countries where management systems lack capacity to control large numbers of fishers influenced by poverty. In contrast, the tropical sea cucumber fishery in Australia's World Heritage listed Great Barrier Reef Marine Park ( GBRMP) is operating in a developed high-income country with relatively few licensed fishers to manage. The development of this fishery is reviewed here in a meta-analysis of catches from 1991 to 2011. The fishery expanded to replace high-value teatfish species ( Holothuria whitmaei and H. fuscogilva), fished heavily in initial stages of the fishery, with newly commercialized medium-value species such as burying blackfish ( Actinopyga spinea) and curryfish ( Stichopus herrmanni). These two species now constitute 80% of total catch. The annual average catch of burying blackfish was 208 tonnes years 2004-11 and curryfish catches increased rapidly at an average annual pace of 200% from 2007-11. This serial harvest pattern occurred in the absence of baseline studies and without independent resource assessments, information required to inform relevant harvest predictions and to determine fishery impacts. This situation does not support ecologically relevant and adaptive decision-making in management and the unfolding catch patterns in the GBRMP follow those in low-income developing countries. The missing knowledge and lack of data serve as arguments to support precautionary reductions in harvests and extending fallow periods in fishing zones. [ABSTRACT FROM AUTHOR]

The article focuses on the imprisonment in lieu orders permissible under Infringements Act 2006 in Victoria and its implications on the Victorian Charter of Human Rights and Responsibilities 2006. It discusses the jurisdiction of two cases Taha v. Broadmeadows Magistrates Court & Ors and Brookes v. Magistrates' Court of Victoria & Anor in this regard. Topics include the Victorian infringements system, Magistrate's duty to acquire an inquisitorial role, and a case study of Zakaria Taha.

Australia's population is ageing and the consequential burden of chronic disease increasingly challenges the health system. This has raised interest in, and awareness of approaches built on multidisciplinary teams and integrated and coordinated care in managing the complex care needs of patient groups such as the chronically ill or frail aged. A systematic investigation of the literature relating to these approaches provided the opportunity to explore the meaning of these terms and their potential application and relevance to the Australian primary health care setting. Five systematic reviews of a sentinel condition and an exemplar approach to coordinated and multidisciplinary care were completed. Common leanings from the individual reviews were identified. The literature suggests that approaches encouraging a coordinated and multidisciplinary plan of care for individual patients and/or particular populations may improve a variety of outcomes. There are many methodological considerations in conducting reviews of complex interventions and in assessing their applicability to the Australian health system. [ABSTRACT FROM AUTHOR]

Abstract: Past phases of aggradation and incision have been studied along a 10 km reach in the Naas Valley in south-eastern Australia. Detailed mapping of the stratigraphy and an ambitious dating exercise, involving 23 optical dates, have been used to distinguish the different periods of aggradation and incision. The dated alluvial sequence shows that a period of aggradation occurred in the very late Pleistocene (ca. 14,000–12,000 years ago). Alluvial deposits are absent for the period 12,000–3300 years ago. Whether this truly reflects no deposition or a series of aggradation and erosion cycles remains unresolved. Aggradation dominated between 3300 and 900 years ago, punctuated by a short incision event around 1300 years ago. Gully erosion contemporaneous with this incision phase is also recorded. Incision has dominated during the last 900 years, cutting down to bedrock. This incision, which is still ongoing, has not been a continuous process, but involved short periods of aggradation. The exposed bedrock and large boulders display numerous scour holes indicating that bedrock has been exposed and abraided for lengthy periods in the past. The aggradation and incision cycles in the late Holocene gave rise to three groups of terraces, today visible along the study reach. Possible causes for the different periods of erosion and deposition are discussed in the context of late Pleistocene and Holocene climate change, land use impacts, and intrinsic factors. [Copyright &y& Elsevier]

An introduction to the journal is presented which discusses articles within the issue on topics including impact of incarceration of a parent on children's care in Australian states such as Victoria and New South Wales, parent recidivism issues and child protection and criminal justice system.

While adjuvant therapy with anti-programmed cell death protein-1 (anti-PD1) for patients with resected stage III/IV melanoma has been shown to improve recurrence-free survival, the overall survival benefit remains uncertain. This study aims to evaluate the impact of adjuvant anti-PD1 therapy on the health-related quality of life (HRQOL) of patients with resected stage III/IV melanoma Data was used from two melanoma registries in Australia and the Netherlands. Patients with resected stage III/IV melanoma treated with adjuvant anti-PD1 who completed a baseline and at least one post-baseline HRQOL assessment were included. HRQOL was assessed using the EORTC QLQ-C30 at baseline, 3, 6, and 12 months. Established thresholds were used for interpreting changes in QLQ-C30 scores. 92 patients were included. Mean symptom and functioning scores improved or remained stable at 12 months compared to baseline. However, a substantial proportion of patients experienced a clinically significant decline in role (39%, μ = −50.8), social (41%, μ = −32.7), or emotional (50%, μ = −25.1) functioning at 12 months compared to baseline. Younger patients were more likely to experience clinically significant deteriorations in role (OR=1.07, 95% CI: 1.02–1.13, p < 0.01) and social (OR=1.06, 95% CI: 1.01–1.11, p = 0.013) functioning. A significant proportion of patients with resected stage III/IV melanoma who received adjuvant anti-PD1 experienced clinically significant declines in role, social and emotional functioning at 12 months compared to baseline. This highlights the HRQOL issues that may arise during adjuvant anti-PD1 therapy which may require supportive care intervention. • We assessed HRQOL in stage III/IV melanoma patients treated with adjuvant anti-PD1 • Many patients' emotional and social functioning deteriorated after adjuvant therapy. • Younger patients experienced more role and social functioning deterioration. • Our study highlights the value of conducting a more detailed analysis of HRQOL data. [ABSTRACT FROM AUTHOR]

Background: The outcome of patients with macroscopic stage III melanoma is poor. Neoadjuvant treatment with ipilimumab plus nivolumab at the standard dosing schedule induced pathological responses in a high proportion of patients in two small independent early-phase trials, and no patients with a pathological response have relapsed after a median follow up of 32 months. However, toxicity of the standard ipilimumab plus nivolumab dosing schedule was high, preventing its broader clinical use. The aim of the OpACIN-neo trial was to identify a dosing schedule of ipilimumab plus nivolumab that is less toxic but equally effective.Methods: OpACIN-neo is a multicentre, open-label, phase 2, randomised, controlled trial. Eligible patients were aged at least 18 years, had a WHO performance status of 0-1, had resectable stage III melanoma involving lymph nodes only, and measurable disease according to the Response Evaluation Criteria in Solid Tumors version 1.1. Patients were enrolled from three medical centres in Australia, Sweden, and the Netherlands, and were randomly assigned (1:1:1), stratified by site, to one of three neoadjuvant dosing schedules: group A, two cycles of ipilimumab 3 mg/kg plus nivolumab 1 mg/kg once every 3 weeks intravenously; group B, two cycles of ipilimumab 1 mg/kg plus nivolumab 3 mg/kg once every 3 weeks intravenously; or group C, two cycles of ipilimumab 3 mg/kg once every 3 weeks directly followed by two cycles of nivolumab 3 mg/kg once every 2 weeks intravenously. The investigators, site staff, and patients were aware of the treatment assignment during the study participation. Pathologists were masked to treatment allocation and all other data. The primary endpoints were the proportion of patients with grade 3-4 immune-related toxicity within the first 12 weeks and the proportion of patients achieving a radiological objective response and pathological response at 6 weeks. Analyses were done in all patients who received at least one dose of study drug. This trial is registered with ClinicalTrials.gov, number NCT02977052, and is ongoing with an additional extension cohort and to complete survival analysis.Findings: Between Nov 24, 2016 and June 28, 2018, 105 patients were screened for eligibility, of whom 89 (85%) eligible patients were enrolled and randomly assigned to one of the three groups. Three patients were excluded after randomisation because they were found to be ineligible, and 86 received at least one dose of study drug; 30 patients in group A, 30 in group B, and 26 in group C (accrual to this group was closed early upon advice of the Data Safety Monitoring Board on June 4, 2018 because of severe adverse events). Within the first 12 weeks, grade 3-4 immune-related adverse events were observed in 12 (40%) of 30 patients in group A, six (20%) of 30 in group B, and 13 (50%) of 26 in group C. The difference in grade 3-4 toxicity between group B and A was -20% (95% CI -46 to 6; p=0·158) and between group C and group A was 10% (-20 to 40; p=0·591). The most common grade 3-4 adverse events were elevated liver enzymes in group A (six [20%)]) and colitis in group C (five [19%]); in group B, none of the grade 3-4 adverse events were seen in more than one patient. One patient (in group A) died 9·5 months after the start of treatment due to the consequences of late-onset immune-related encephalitis, which was possibly treatment-related. 19 (63% [95% CI 44-80]) of 30 patients in group A, 17 (57% [37-75]) of 30 in group B, and nine (35% [17-56]) of 26 in group C achieved a radiological objective response, while pathological responses occurred in 24 (80% [61-92]) patients in group A, 23 (77% [58-90]) in group B, and 17 (65% [44-83]) in group C.Interpretation: OpACIN-neo identified a tolerable neoadjuvant dosing schedule (group B: two cycles of ipilimumab 1 mg/kg plus nivolumab 3 mg/kg) that induces a pathological response in a high proportion of patients and might be suitable for broader clinical use. When more mature data confirm these early observations, this schedule should be tested in randomised phase 3 studies versus adjuvant therapies, which are the current standard-of-care systemic therapy for patients with stage III melanoma.Funding: Bristol-Myers Squibb. [ABSTRACT FROM AUTHOR]

We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock of hair donated by an Aboriginal man from southern Western Australia in the early 20th century. We detect no evidence of European admixture and estimate contamination levels to be below 0.5%. We show that Aboriginal Australians are descendants of an early human dispersal into eastern Asia, possibly 62,000 to 75,000 years ago. This dispersal is separate from the one that gave rise to modern Asians 25,000 to 38,000 years ago. We also find evidence of gene flow between populations of the two dispersal waves prior to the divergence of Native Americans from modern Asian ancestors. Our findings support the hypothesis that present-day Aboriginal Australians descend from the earliest humans to occupy Australia, likely representing one of the oldest continuous populations outside Africa. [ABSTRACT FROM AUTHOR]

In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein's antiviral effect., (Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)

The population history of Aboriginal Australians remains largely uncharacterized. Here we generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama-Nyungan languages) and 25 Papuans from the New Guinea Highlands. We find that Papuan and Aboriginal Australian ancestors diversified 25-40 thousand years ago (kya), suggesting pre-Holocene population structure in the ancient continent of Sahul (Australia, New Guinea and Tasmania). However, all of the studied Aboriginal Australians descend from a single founding population that differentiated ~10-32 kya. We infer a population expansion in northeast Australia during the Holocene epoch (past 10,000 years) associated with limited gene flow from this region to the rest of Australia, consistent with the spread of the Pama-Nyungan languages. We estimate that Aboriginal Australians and Papuans diverged from Eurasians 51-72 kya, following a single out-of-Africa dispersal, and subsequently admixed with archaic populations. Finally, we report evidence of selection in Aboriginal Australians potentially associated with living in the desert.