1. Genetic Characterization of Archived Bunyaviruses and their Potential for Emergence in Australia.
- Author
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Bixing Huang, Firth, Cadhla, Watterson, Daniel, Allcock, Richard, Colmant, Agathe M. G., Hobson-Peters, Jody, Kirkland, Peter, Hewitson, Glen, McMahon, Jamie, Hall-Mendelin, Sonja, van den Hurk, Andrew F., Warrilow, David, and Huang, Bixing
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BUNYAVIRUSES , *VIRAL genetics , *CLASSIFICATION of viruses , *LABORATORY mice - Abstract
To better understand the diversity of bunyaviruses and their circulation in Australia, we sequenced 5 viruses (Gan Gan, Trubanaman, Kowanyama, Yacaaba, and Taggert) isolated and serologically identified 4 decades ago as members of the family Bunyaviridae. Gan Gan and Trubanaman viruses almost perfectly matched 2 recently isolated, purportedly novel viruses, Salt Ash and Murrumbidgee viruses, respectively. Kowanyama and Yacaaba viruses were identified as being related to members of a large clade containing pathogenic viruses. Taggert virus was confirmed as being a nairovirus; several viruses of this genus are pathogenic to humans. The genetic relationships and historical experimental infections in mice reveal the potential for these viruses to lead to disease emergence. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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