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To explore the predictive value of rapid sequential organ failure score(qSOFA)combined with serum homocysteine( Hcy) and triacylglycerol(TG) in the short-term prognosis of acute pancreatitis(AP). The 210 AP patients who were admitted to Department of Gastroenterology, the First Affiliated Hospital of Suzhou University from September 2019 to September 2021 were selected as the research objects. According to the Atlanta AP classification guidelines,they were divided into 125 cases of mild AP (MAP group),45 cases of moderate and severe AP(MSAP group)and 40 cases of severe AP(SAP group). The qSOFA score, Hcy and TG levels of the three groups were compared. According to the prognosis 28 days after admission, all patients were divided into 192 cases in the survival group and 18 cases in the death group. Univariate and multivariate logistic regression were used to analyze the prognostic factors of AP patients. The predictive value of qSOFA score, Hcy and TG on the short-term prognosis of AP patients was analyzed by receiver operating characteristic (ROC) curve. The qSOFA score, Hcy and TG levels in SAP group and MSAP group were higher than those in MAP group, and those in SAP group were higher than those in MSAP group (P<0.05). Univariate and multivariate logistic regression analysis showed that higher qSOFA score and higher levels of TG and Hcy were the risk factors of death in AP patients(P<0. 05). The area under the curve (AUC) of qsofa score combined with Hcy and TG to predict the short-term prognosis of AP patients was 0.982, which was significantly higher than 0.715, 0.780 and 0.782 detected by the three indexes alone. qSOFA score, TG and Hcy levels are the influencing factors of short-term prognosis of AP patients, and the combined detection of qsofa score, Hcy and TG levels has high predictive value for the short-term prognosis of AP patients. [ABSTRACT FROM AUTHOR]