1. Nasal NK/T-cell lymphoma: epidemiology and pathogenesis.
- Author
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Aozasa K, Takakuwa T, Hongyo T, and Yang WI
- Subjects
- Asia epidemiology, Environmental Exposure adverse effects, Epstein-Barr Virus Infections complications, Genes, p53 genetics, Humans, Killer Cells, Natural virology, Latin America epidemiology, Pesticide Residues adverse effects, Proto-Oncogene Proteins c-kit genetics, Killer Cells, Natural pathology, Lymphoma, T-Cell epidemiology, Lymphoma, T-Cell genetics, Lymphoma, T-Cell virology, Nose Neoplasms epidemiology, Nose Neoplasms genetics, Nose Neoplasms virology
- Abstract
Nasal NK/T-cell lymphoma (NKTCL) is an uncommon disease, but usually shows a highly aggressive clinical course. The disease is much more frequent in Asian and Latin American countries than in Western countries, and is universally associated with Epstein-Barr virus (EBV) infection. Analyses of gene mutations, especially p53 and c-KIT, revealed the different frequencies by district. Epidemiological studies revealed the changes of the disease frequency in Korea during the period from 1977-1989 to 1990-1996. Case-control study showed that the exposure to pesticides and chemical solvents could be causative of NKTCL. Further studies including HLA antigen typing of patients is necessary to further clarify the disease mechanism.
- Published
- 2008
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