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Your search keyword '"Mizuno, Y."' showing total 3 results
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3 results on '"Mizuno, Y."'

1. [Travelers' vaccine].

Author

Mizuno Y and Kano S

Subjects
Africa, Age Factors, Asia, Humans, Middle East, Time Factors, Communicable Disease Control, Travel, Vaccines administration & dosage, Vaccines adverse effects
Published
2007

2. Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population.

Author

Funayama M, Li Y, Tomiyama H, Yoshino H, Imamichi Y, Yamamoto M, Murata M, Toda T, Mizuno Y, and Hattori N

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Asia ethnology, Brain enzymology, Brain physiopathology, Cohort Studies, DNA Mutational Analysis, Female, Gene Frequency, Genetic Markers, Genetic Testing, Genotype, Humans, Japan ethnology, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Male, Middle Aged, Mutation genetics, Parkinson Disease ethnology, Brain Chemistry genetics, Genetic Predisposition to Disease genetics, Parkinson Disease enzymology, Parkinson Disease genetics, Protein Serine-Threonine Kinases genetics
Abstract

To assess the effect of genetic factors on sporadic Parkinson disease, we performed a case-control study of a variant (G2385R) in Leucine-Rich Repeat kinase 2 among the Japanese population. The G2385R (c.7153G>A) variant was reported as a risk factor for sporadic Parkinson disease in the Chinese population from Taiwan and Singapore. Genotyping was conducted in 448 Parkinson disease patients and 457 healthy controls. The frequency of A allele in Parkinson disease was significantly higher than in the control (P=1.24x10(-4), odds ratio 2.63, 95% confidence interval 1.56-4.35). Our results suggest that the G2385R variant is a risk factor for sporadic Parkinson disease in the Asian population.

Published
2007
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3. PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations.

Author

Hatano Y, Sato K, Elibol B, Yoshino H, Yamamura Y, Bonifati V, Shinotoh H, Asahina M, Kobayashi S, Ng AR, Rosales RL, Hassin-Baer S, Shinar Y, Lu CS, Chang HC, Wu-Chou YH, Ataç FB, Kobayashi T, Toda T, Mizuno Y, and Hattori N

Subjects
Age of Onset, Asia epidemiology, Chromosome Disorders ethnology, Chromosome Disorders metabolism, Chromosome Mapping, DNA Mutational Analysis, Female, Gene Frequency genetics, Genetic Linkage genetics, Genetic Markers genetics, Genetic Testing, Haplotypes genetics, Humans, Male, Microsatellite Repeats genetics, Middle East epidemiology, Parkinson Disease ethnology, Parkinson Disease metabolism, Pedigree, Chromosome Disorders genetics, Genes, Recessive genetics, Genetic Predisposition to Disease genetics, Mutation genetics, Parkinson Disease genetics, Protein Kinases genetics
Abstract

The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for parkin and DJ-1 mutations. Eight families including three Japanese, two Taiwanese, one Turkish, one Israeli, and one Philippine showed evidence of linkage with PARK6 with multipoint log of the odds (lod) score of 9.88 at D1S2732. The results indicate worldwide distribution of PARK6-linked parkinsonism.

Published
2004
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