1. The haemoglobin glycation index is associated with nonalcoholic fatty liver disease in healthy subjects.
- Author
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Yoo JH, Kang YM, Cho YK, Lee J, Jung CH, Park JY, Ryu OH, Kim HK, and Lee WJ
- Subjects
- Adult, Asia epidemiology, Asian People statistics & numerical data, Body Mass Index, Female, Health Surveys methods, Health Surveys statistics & numerical data, Humans, Lipids blood, Liver diagnostic imaging, Logistic Models, Male, Middle Aged, Non-alcoholic Fatty Liver Disease blood, Non-alcoholic Fatty Liver Disease epidemiology, Prevalence, Retrospective Studies, Ultrasonography methods, Waist Circumference, Glycated Hemoglobin analysis, Healthy Volunteers statistics & numerical data, Liver pathology, Non-alcoholic Fatty Liver Disease diagnosis
- Abstract
Objectives: The hemoglobin glycation index (HGI) quantifies interindividual variations in glycated hemoglobin (HbA1c) and is associated with diabetic complications and metabolic diseases. However, information on the association between HGI and non-alcoholic fatty liver disease (NAFLD) in healthy subjects is limited, particularly in Asian populations. This study aimed to investigate the association between HGI and NAFLD in a healthy Korean cohort., Design: Subjects were stratified in quartiles according to their HGI level. NAFLD was diagnosed by hepatic ultrasonography, hepatic steatosis index and fatty liver index. Multiple logistic regression analysis was performed to evaluate the association between HGI quartiles and the risk of NAFLD., Patients: Data from subjects without diabetes who underwent liver ultrasonography during routine health examinations were retrospectively reviewed., Results: Data from 14 465 subjects were included in the analysis. The prevalence of NAFLD increased significantly with each HGI quartile (24.8%, 29.7%, 32.6% and 40.6% in quartiles 1-4, respectively; P < 0.001). In comparison with the lowest HGI quartile group, the highest quartile exhibited worse metabolic parameters, including body weight, waist circumference, body mass index and lipid profiles. Multiple logistic regression analysis adjusted for multiple factors showed that the odds ratio of having NAFLD was 1.564 (95% CI: 1.350-1.813, P < 0.001) in the highest HGI quartile., Conclusions: Elevated HGI levels are independently associated with NAFLD in a healthy Asian population., (© 2019 John Wiley & Sons Ltd.)
- Published
- 2019
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