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Introduction: Considered the first plant cultivated by man, Cannabis has historical records dating from 4000 B.C. It is believed to have originated in the temperate and tropical regions of Asia. Over time, the plant has stood out due to its high therapeutic potential for various pathologies, thus leading to a need for health professionals to understand its applications, focusing on the quality of care offered to the patient that makes use of its phytotherapics, being they the base of the main cannabinoids of the plant, Cannabidiol (CBD) and Tetrahydrocannabinol (THC). Objective: To review the scientific literature on the knowledge of nursing professionals related to the care of patients who use cannabinoid-based drug therapy. Methods: Integrative literature review, seeking to gather results and develop an explanation on the topic, with the keywords "Cannabis", "Marijuana"or "CBD/THC", combinedwith "Nursing"or "Nurse". Results: The final sample consisted of 13 articles, divided into two topics, the first related to the knowledge of nursing professionals and the second, presenting the professionals' view on the use of Cannabis as a medicinal treatment. Conclusion: There was an agreement between studies reviewed on both topics, mainly related to the need to expand the specific knowledge of professionals about Cannabis for therapeutic purposes. Provide an improvement in the quality of teaching related to medical Cannabis, as well as complementary courses for trained professionals, seeking to ensure an improvement in the quality of care for patients. [ABSTRACT FROM AUTHOR]