1. Molecular epidemiology of rotaviruses in the south-east Asian region from 2009 to 2015.
- Author
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Giri S, Priya Hemavathy R, Arumugam R, Sherchand JB, Thu HM, Galagoda G, Myat TW, Abeysinghe N, Gunasekara M, Janakan N, Pradhan R, Bura V, Wijesinghe P, and Kang G
- Subjects
- Antigens, Viral, Asia, Southeastern epidemiology, Child, Preschool, Diarrhea epidemiology, Diarrhea virology, Enzyme-Linked Immunosorbent Assay, Feces virology, Gastroenteritis epidemiology, Gastroenteritis virology, Genetic Variation, Genotype, Humans, Infant, Infant, Newborn, Nepal epidemiology, RNA, Viral genetics, Rotavirus isolation & purification, Sri Lanka epidemiology, Hospitalization statistics & numerical data, Rotavirus genetics, Rotavirus Infections epidemiology
- Abstract
Background: In Asia, rotavirus accounts for approximately 45% of admissions due to acute gastroenteritis in children <5 years, and causes about 145,000 deaths every year. We studied the distribution of rotavirus strains from Myanmar, Sri Lanka, and Nepal during 2009-2015., Methods: Stool samples collected from children <5 years of age hospitalized with acute diarrhea in the three sites and positive for rotavirus antigen by enzyme immunoassay (EIA) were sent to the Christian Medical College, Vellore from 2009 to 2015. G and P typing of rotavirus strains were performed using reverse-transcription polymerase chain reaction (RT-PCR)., Result: Of the 2354 EIA positive samples tested, G12P[8] (36.8%), G1P[8] (30.1%), and G12P[6] (41.3%) were the most common strains isolated from Myanmar, Sri Lanka, and Nepal respectively., Conclusion: There was substantial diversity of rotavirus genotypes, and continued surveillance in developing countries of Asia will help in understanding the epidemiology of rotavirus before and after introduction of vaccines., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Published
- 2018
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