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1. Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of Shigella dysenteriae type 1.

Author

Talukder KA, Khajanchi BK, Islam MA, Islam Z, Dutta DK, Rahman M, Watanabe H, Nair GB, and Sack DA

Subjects
Asia, Southeastern, Drug Resistance, Bacterial genetics, Dysentery, Bacillary microbiology, Fluoroquinolones pharmacology, Humans, Microbial Sensitivity Tests, Molecular Sequence Data, Mutation, Anti-Bacterial Agents pharmacology, DNA Gyrase genetics, DNA Topoisomerase IV genetics, Quinolones pharmacology, Shigella dysenteriae drug effects, Shigella dysenteriae genetics
Abstract

We examined the quinolone resistance-determining region (QRDR) of gyrA, gyrB, and parC of recently isolated fluoroquinolone-resistant S. dysenteriae type 1 strains from south Asia and compared data with fluoroquinolone-susceptible strains associated with previous epidemics of 1978, 1984, and 1994. In fluoroquinolone-resistant strains, double mutations (Ser83-->Leu, Asp87-->Asn or Gly) and a single mutation (Ser80-->Ile) were detected in the QRDRs of gyrA and parC, respectively.

Published
2006
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