1. A case of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in East Asia.
- Author
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Tohge R, Nagao M, Yagishita A, and Matsubara S
- Subjects
- Chronic Disease, Encephalitis pathology, Asia, Eastern, Female, Humans, Inflammation diagnosis, Inflammation drug therapy, Inflammation pathology, Middle Aged, Syndrome, Encephalitis diagnosis, Encephalitis drug therapy, Pons pathology, Steroids therapeutic use, T-Lymphocytes pathology
- Abstract
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome is a clinically and radiologically distinct pontine-predominant perivascular neuroinflammation showing T lymphocyte infiltration. It is assumed to have an autoimmune or other inflammatory mediated pathogenesis. We report the first known case of CLIPPERS in East Asia, characterized by multiple punctate enhancement of the brainstem extending to the bilateral posterior limb of the internal capsule and caudal to the spinal cord conus. The patient had elevated IgE levels and a history of allergies, suggesting that lesions may arise from neuroinflammation in response to T lymphocyte infiltration into perivascular spaces.
- Published
- 2012
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