1. HIV Type 1 Subtype A1 Dominates in Armenia.
- Author
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Laga V, Vasilyev A, Lapovok I, Grigoryan S, Papoyan A, Glushchenko N, Kazennova E, and Bobkova M
- Subjects
- Adult, Armenia epidemiology, Cohort Studies, Drug Resistance, Viral, Female, HIV-1 drug effects, HIV-1 isolation & purification, Heterosexuality, Humans, Male, Molecular Epidemiology, Molecular Sequence Data, Moscow epidemiology, Mutation, Missense, Phylogeny, Sequence Analysis, DNA, Sequence Homology, Substance Abuse, Intravenous complications, pol Gene Products, Human Immunodeficiency Virus, Genotype, HIV Infections epidemiology, HIV Infections virology, HIV-1 classification, HIV-1 genetics
- Abstract
Objective: There is scarce information about the molecular epidemiology of HIV-infection in Armenia (former USSR). The objective of this work was to estimate the distribution of HIV-1 subtypes in this country and get any information about HIV drug resistance in naÏve patients., Design: A joint study involving 78 patients was carried out in Yerevan, Armenia and Moscow, Russia in 2009-2013. The cohort studies included mostly IDUs (28.2%) and heterosexuals (69.2%)., Results: The phylogenetic analyses based on population sequencing of partial pol gene found subtype A1 being the most prevalent (92.3%), followed by subtype B (3.9%). The HIV-1 tropism inferred from env V3-loop sequences was determined in 27 samples, among them R5-tropic viruses were found in 13 (48.1%) patients and X4- variants--in 14 (51.9%) patients. The prevalence of drug resistance in naïve patients was low (1.5%) with the only one mutation K219Q found., Conclusion: The composition and distribution of HIV-1 genetic variants in Armenia are evidently influenced by the Russian and other FSU countries epidemic, due to the significant volume of Armenian migrant/re-emigrant flows. Continued surveillance of HIV-1 circulating subtypes and drug resistance in Armenia is important for the proper management of HIV infection in this country.
- Published
- 2015
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