1. Cytotoxic hydroxylated triterpene alcohol ferulates from rice bran.
- Author
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Luo HF, Li Q, Yu S, Badger TM, and Fang N
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Arkansas, Drug Screening Assays, Antitumor, Humans, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Triterpenes chemistry, Triterpenes pharmacology, Tumor Cells, Cultured, Antineoplastic Agents, Phytogenic isolation & purification, Oryza chemistry, Triterpenes isolation & purification
- Abstract
Three hydroxylated triterpene alcohol ferulates, (24S)-cycloart-25-ene-3 beta,24-diol-3 beta-trans-ferulate (1), (24R)-cycloart-25-ene-3 beta,24-diol-3 beta-trans-ferulate (2), and cycloart-23Z-ene-3 beta,25-diol-3 beta-trans-ferulate (3), along with known compounds cycloartenol trans-ferulate (4) and 24-methylenecycloartanol trans-ferulate (5) were isolated from rice bran. Their structures were elucidated by means of chemical and spectroscopic analysis. Compounds 2-5 showed moderate cytotoxicity against MCF-7 cells.
- Published
- 2005
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