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Context: Botulism is an important public health problem in Argentina, but obtaining antitoxin rapidly has been difficult because global supplies are limited. In January 1998, a botulism outbreak occurred in Buenos Aires.Objectives: To determine the source of the outbreak, improve botulism surveillance, and establish an antitoxin supply and release system in Argentina.Design, Setting, and Participants: Cohort study in January 1998 of 21 drivers of a specific bus route in urban Buenos Aires.Main Outcome Measure: Occurrence of botulism and implication of a particular food as the vehicle causing this outbreak.Results: Nine (43%) of 21 bus drivers developed botulism, presenting with gastroenteritis, symptoms of acute cranial nerve dysfunction including ptosis, dysphagia, blurred vision, and motor weakness. One driver experienced respiratory failure. Type A toxin was detected from 3 of 9 patients' serum samples. All drivers received botulism antitoxin; there were no fatalities. Consumption of matambre (Argentine meat roll) was significantly associated with illness. Among 11 persons who ate matambre, 9 developed illness, compared with none of those who did not eat it (P<.001). The matambre had been cooked in water at 78 degrees C to 80 degrees C for 4 hours, sealed in heat-shrinked plastic wrap, and stored in refrigerators that did not cool adequately. Subsequently, a botulism surveillance and antitoxin release system was established.Conclusions: Insufficient cooking time and temperatures, storage in heat-shrinked plastic wrap, and inadequate refrigeration likely contributed to Clostridium botulinum spore survival, germination, and toxin production. A rapid-response botulism surveillance and antitoxin release system in Argentina should provide more timely distribution of antitoxin to patients and may serve as a model for other nations. [ABSTRACT FROM AUTHOR]

This study describes the first multicentered study of acute lower respiratory infection viral etiology in young children from four different geographical areas of Argentina. A total of 1,278 children under 5 years of age, hospitalized in primary care centers from Buenos Aires, Córdoba, Santa Fé and Mar del Plata cities during a 2-year period were studied (1993-1994). Nasopharyngeal aspirates were investigated for respiratory syncytial virus (RSV), adenovirus, parainfluenza, and influenza A and B viruses by indirect immunofluorescence. Out of the patients studied, 946 (74%) were under 1 year of age. Viruses were detected in 399 patients (32%). RSV was observed in 25.3% of the samples, representing 78.2% of all viral positive cases. Adenoviruses were detected in 2.5% of the cases, parainfluenza in 2.2%, influenza A in 2.1%, and influenza B in 0.2%. Compared with other viruses, the higher RSV frequency was statistically significant (P < 0.000). Most RSV cases were detected between May and September with a significant peak in July (P < 0.000). Pneumonia was observed in 46% of the patients, bronchiolitis in 41% and other entities in 13%. The case fatality rate observed during the 2 year study was 0.73%. Most of the above respiratory viruses were detected in the four cities, however, the frequency of RSV and influenza were different in the southern city., (Copyright 2001 Wiley-Liss, Inc.)

Unlabelled: The objective was to determine annual mortality rate for asthma and chronic obstructive pulmonary disease (COPD) from 1980 to 1998, in Argentina. Data base on death certificates from the National Ministry of Health were evaluated. They were individualized for COPD: ICD-9: 490 to 496 and ICD-10: J-40 to J47; for asthma: ICD-9: 493 and ICD-10: J44, J45-J46. Global mortality rate was calculated from each code and for 24 provinces. For asthma, the adjusted mortality rate for 5-34 year-old patients was calculated. Population data were provided by National Institute of Statistics and Census. Global mortality rate for asthma increased from 3.37 in 1980 to 3.96/100,000 in 1985 and decreased from 3.16 in 1991 to 1.74 in 1997 (-30.8%, p < 0.0001) and increased to 2.18 in 1998. Asthma's 5-34 year old mortality rate increased from 0.72 in 1980 to 1.12/100,000 in 1986, and decreased to 0.35 in 1998 (-70%, p < 0.0001). Global mortality rate for COPD increased from 12.76/100,000 in 1980 to 27.16/100,000 in 1998 (+113%, p < 0.0001). There were marked inter-provinces differences for asthma and COPD., In Conclusion: as in developed countries, Argentine mortality rate for asthma has decreased, probably related to dissemination of international and national guides. On the other hand, COPD has increased significantly.

In March 1995 the first case of a familiar outbreak of Hantavirus pulmonary syndrome (HPS) was notified in El Bolson, in the South of Argentina. Until December 15, 1996, a total of 77 cases of HPS had been notified with 48% mortality, distributed in three geographical areas of the country, South, North and Center. During 1996, of the 19 cases from El Bolsón, three were local physicians, one of whom -during the prodrome of her illness- travelled to Buenos Aires to be attended. In the hospital, two of the physicians who assisted her, developed HPS 27 and 28 days after the first contact. These data suggest for the first time the possibility of interhuman transmission of the Hantavirus responsible for the pulmonary syndrome.