1. OCEANIA: real-world study of ovarian cancer treatment patterns across multiple lines of therapy in Argentina and Brazil.
- Author
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Soares C, Abreu G, Nogueira da Silva TL, Queiroz J, Menezes P, Bernardino G, Pires T, Carrizo M, Felice R, Riggi MC, Cravero F, Ribeiro de Souza ALA, and Jotimliansky L
- Subjects
- Humans, Female, Argentina epidemiology, Brazil epidemiology, Middle Aged, Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Antineoplastic Combined Chemotherapy Protocols adverse effects, Adult, Ovarian Neoplasms drug therapy, Ovarian Neoplasms epidemiology, Ovarian Neoplasms therapy, Ovarian Neoplasms mortality
- Abstract
Aim: To evaluate real-world data on treatment patterns in Argentina and Brazil in patients with ovarian cancer. Methods: This study evaluated de-identified antineoplastic exposure data from a private healthcare provider in Argentina and health claims database (Orizon) in Brazil from 2010 to 2019 and 2015 to 2020, respectively. Results: Platinum-based chemotherapy was the most common first-line therapy (Argentina: n =311 [87.6%]; Brazil: n = 1142 [79.3%]). The proportion of patients receiving platinum-based chemotherapy declined across both populations from first- to second-line, while use of non-platinum-based, targeted, and hormone therapies increased. Duration of platinum-based treatment and time to next treatment decreased from first- to fourth-line. Conclusion: There is an unmet need for effective therapies that can prolong time to next treatment in ovarian cancer in Argentina and Brazil.
- Published
- 2024
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