1. Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires City.
- Author
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Fridman O, Porcile R, Morales AV, Gariglio LO, Potenzoni MA, and Turk Noceto PC
- Subjects
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Argentina, Cross-Sectional Studies, Female, Humans, Hypertension blood, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Sex Factors, Young Adult, Homocysteine blood, Hypertension genetics, Methylenetetrahydrofolate Reductase (NADPH2) genetics
- Abstract
We examined the relationship between the 677C >T polymorphism in the MTHFR gene and tHcy in normotensive (NT) and hypertensive (HT) subjects and the influence of sex and age in a cross-sectional study. Smoking habits, history of vascular disease, diabetes, and tHcy were significantly associated with T allele as hypertension risk factors. The T allele was significantly related with higher tHcy in (i) men versus women (P < .01), (ii) men and women older than 47 years versus the younger ones (P < .05 and P < .001, respectively), (iii) HT women versus NT women (P < .01), and (iv) older HT women versus older NT women (P < .01). We found an association between the 677C>T MTHFR polymorphism and tHcy with hypertension that in women is manifested with age.
- Published
- 2013
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