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The North China Plain (NCP) is one of the global hotspots of groundwater depletion, groundwater is almost the only source of water for agricultural, industrial and drinking water in this region. After long-term's over-exploitation of deep groundwater, there appeared several deep groundwater depression cones, such as Cangzhou cone, Dezhou cone, Hengshui cone, Tianjin cone, etc., in which the Cangzhou cone is one of the typical cones for its special geography and hydrogeology conditions. In this study, the authors intended to analyze the evolution characteristics and influence factors of deep groundwater depression cone in Cangzhou region, especially the No. III aquifer depression cone, which is the main exploitation zone in this region. Analysis of the evolution of the groundwater depression cone of the No. III aquifer group in Cangzhou region showed that this process can be divided into four stages, namely, development, stable development, rapid expansion, and gradual recovery. The shape and evolution characteristics of the depression cone at different stages are described by analyzing the evolution of the −30, −40, and −50 contours of the groundwater table, for example the closed area of water table contour of −50 m has been enlarged from 95 km in 1985 to 6 528.5 km in 2005. The dominant factors that affect the evolution characteristics at different stages are proposed. The results showed that relatively long dry periods with less precipitation, special geological and hydrogeological conditions, and sharply increased water consumption for industrial and agricultural development are the main factors that cause the formation of deep groundwater depression cones. Meanwhile, an environmental response against groundwater exploitation is presented, and rational solutions are suggested to avert water crisis. [ABSTRACT FROM AUTHOR]