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Background: Muskoxen are important ecosystem components and provide food, economic opportunities, and cultural well-being for Indigenous communities in the Canadian Arctic. Between 2010 and 2021, Erysipelothrix rhusiopathiae was isolated from carcasses of muskoxen, caribou, a seal, and an Arctic fox during multiple large scale mortality events in the Canadian Arctic Archipelago. A single strain ('Arctic clone') of E. rhusiopathiae was associated with the mortalities on Banks, Victoria and Prince Patrick Islands, Northwest Territories and Nunavut, Canada (2010–2017). The objectives of this study were to (i) characterize the genomes of E. rhusiopathiae isolates obtained from more recent muskox mortalities in the Canadian Arctic in 2019 and 2021; (ii) identify and compare common virulence traits associated with the core genome and mobile genetic elements (i.e. pathogenicity islands and prophages) among Arctic clone versus other E. rhusiopathiae genomes; and iii) use pan-genome wide association studies (GWAS) to determine unique genetic contents of the Arctic clone that may encode virulence traits and that could be used for diagnostic purposes. Results: Phylogenetic analyses revealed that the newly sequenced E. rhusiopathiae isolates from Ellesmere Island, Nunavut (2021) also belong to the Arctic clone. Of 17 virulence genes analysed among 28 Arctic clone isolates, four genes – adhesin, rhusiopathiae surface protein-A (rspA), choline binding protein-B (cbpB) and CDP-glycerol glycerophosphotransferase (tagF) – had amino acid sequence variants unique to this clone when compared to 31 other E. rhusiopathiae genomes. These genes encode proteins that facilitate E. rhusiopathiae to attach to the host endothelial cells and form biofilms. GWAS analyses using Scoary found several unique genes to be overrepresented in the Arctic clone. Conclusions: The Arctic clone of E. rhusiopathiae was associated with multiple muskox mortalities spanning over a decade and multiple Arctic islands with distances over 1000 km, highlighting the extent of its spatiotemporal spread. This clone possesses unique gene content, as well as amino acid variants in multiple virulence genes that are distinct from the other closely related E. rhusiopathiae isolates. This study establishes an essential foundation on which to investigate whether these differences are correlated with the apparent virulence of this specific clone through in vitro and in vivo studies. [ABSTRACT FROM AUTHOR]

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The Arctic is perceived as an area that requires increased North American Aerospace Defense Command (NORAD) attention. On the one hand, the region has always been of particular concern to NORAD, especially during the Cold War. From this perspective, attention to the Arctic is business as usual. On the other hand, increased potential traffic in the region due to warmer temperatures, natural resource exploitation, and tourism could increase threats to North America and create the need for a new NORAD posture. This paper reviews the challenges facing the Arctic, the perceived new urgency for attention, the command and control structures of NORAD, and NORAD's specific preoccupations in order to answer the question: does the Arctic represent status quo for NORAD or does NORAD need to change, fundamentally, its approach to the North? This paper ultimately argues for the former. [ABSTRACT FROM PUBLISHER]

The article provides information on the issue of hegemon in Arctic region and the foreign policies of Canada. It informs that Russia is considered as the hegemon in the Arctic region but Canada has to fight with both power of the U.S. and Russia. As Canada is a middle power it needs to cross check its foreign policies with the two powerful countries and should never declare war against them.