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1. Saliniquinone Derivatives, Saliniquinones G-I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252.

Author

Zhou L, Chen X, Sun C, Chang Y, Huang X, Zhu T, Zhang G, Che Q, and Li D

Subjects
Animals, Antarctic Regions, Anthraquinones chemistry, Anti-Bacterial Agents chemistry, Aquatic Organisms, Microbial Sensitivity Tests, Nocardiopsis, Anthraquinones pharmacology, Anti-Bacterial Agents pharmacology, Staphylococcus drug effects
Abstract

Four new anthraquinone derivatives, namely saliniquinones G-I ( 1 - 3 ) and heraclemycin E ( 4 ), were obtained from the Antarctic marine-derived actinomycete Nocardiopsis aegyptia HDN19-252, guided by the Global Natural Products Social (GNPS) molecular networking platform. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, and ECD analyses. Compounds 1 and 2 showed promising inhibitory activity against six tested bacterial strains, including methicillin-resistant coagulase-negative staphylococci (MRCNS), with MIC values ranging from 3.1 to 12.5 μM.

Published
2021
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