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Purpose: This study is aimed at making an inspection of the effects of collaborative innovation network characteristics on firm innovation performance, and the intermediary roles of knowledge transfer efficiency is taken into account. Design/methodology/approach: This study used a convenient sampling method to obtain population and samples. Using data obtained by publishing online and paper questionnaires, and using on-site interviews in Anhui Province in the Yangtze River Delta region of China, descriptive analysis, regression analysis and correlation analysis are utilized to study the direct influence of collaborative innovation network characteristics on knowledge transfer efficiency as well as firm innovation performance, and the intermediary roles of knowledge transfer efficiency on firm innovation performance, respectively. In this study, 3,000 questionnaires were distributed to the employees of enterprises engaged in research and development (R&D) activities, of which 2,560 were valid. With the help of SPSS24.0 software, the reliability and validity of the questionnaire was analyzed. Findings: The results are indicative of that network centrality and relationship strength positively affect knowledge transfer efficiency and firm innovation performance. Nevertheless, network scale has no significant correlation with knowledge transfer efficiency and enterprise innovation performance. In addition, knowledge transfer efficiency is an intermediary between collaborative innovation network characteristics and enterprise innovation performance, and positively affects enterprise innovation performance, which demonstrated that managers should take advantage of collaborative innovation network characteristics to elevate knowledge transfer efficiency because well-realized transferals of knowledge can help accelerate the coordination of resources in knowledge, and finally bring about the advancement of firm's innovation abilities and performance. Research limitations/implications: There are few previous studies that fully examined the relationships among collaborative innovation network characteristics, knowledge transfer efficiency and firm innovation performance. This paper developed previous researches on the relationships between collaborative innovation network characteristics, knowledge transfer efficiency and firm innovation performance. The mediation of knowledge transfer efficiency on the relationship between collaborative innovation network characteristics and firm innovation performance is analyzed. Further, studies on collaborative innovation network characteristics using data obtained from employees engaged in R&D activities are very limited in the literature. On account of that, the findings in this study may make sense to the innovation ability of innovative enterprise and expand the literature in the field of enterprise strategic management and knowledge management. Practical implications: This analysis shows that collaborative innovation network characteristics have both positive and negative effects on firm innovation performance. Therefore, business managers should pay attention to their position in the collaborative innovation network and maintain the relationship strength with other innovation subjects. Special consideration should be given to the knowledge transfer of innovative enterprises, so as to improve firm innovation performance practically. Originality/value: The study may provide additional understandings for researchers, government managers, universities and enterprises with regard to strategic management from the visual angle of innovation ecosystems. It is instrumental in the exploration of the mechanisms enabling firm innovation performance. [ABSTRACT FROM AUTHOR]