1. Imported dengue from 2013 Angola outbreak: Not just serotype 1 was detected.
- Author
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Abreu, Cândida, Silva-Pinto, André, Lazzara, Daniela, Sobrinho-Simões, Joana, Guimarães, João Tiago, and Sarmento, António
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DISEASE outbreaks , *DENGUE , *SEROTYPES , *POLYMERASE chain reaction , *NS1 viral protein , *IMMUNOGLOBULIN M , *DISEASE risk factors - Abstract
Background All the reports from Angola’s 2013 dengue outbreak revealed serotype 1. However, previously dengue serotypes 1–4 have been reported in Africa and in 2014 serotype 4 was reported in Angola. Objectives To report dengue serotypes in patients returning from Angola during 2013 outbreak. Study design Retrospective, cross-sectional study. We serotyped the dengue by an in house Polymerase Chain Reaction technique in randomly selected cases. Results From the 2013 Angola’s dengue outbreak we treated 47 adult patients. None had history of past dengue. A combo kit test for dengue revealed positive NS1 antigen in 39 and IgM antibodies in 8. From 17 randomly patients tested by RNA Real Time-PCR, 11 were positive: 7 for DENV-1, 2 for DENV-2, 1 for DENV-3 (co-infected with DENV-1) and 1 for DENV-4. None had a complicated or fatal evolution. Conclusion Unlike previous reports the 4 serotypes were detected, and this resulted in a different epidemiological situation, raising the risk of future outbreaks of severe dengue. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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