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Introduction: Small bowel obstruction accounts for 60%-85% of cases of intestinal obstruction. MDCT is now readily available and has advantages over classic helical CT in the imaging of the mesenteric vasculature and of the bowel. Multidetector CT provides good spatial and contrast resolution, multiplanar reconstructions and more efficient scanning with few or no artifacts. Aims and objectives: To assess the role of MDCT in evaluation of clinically suspected acute small bowel obstruction. Methodology: This was a prospective study conducted on 50 patients suffering from clinically suspected acute small bowel obstruction in Department of Radiodiagnosis and Imaging, Govt. Medical College, Amritsar. The final diagnosis was confirmed by pathological correlation, post-operative data and clinical response to medical treatment. Multi Detector Computed Tomography imaging was performed for each patient. The data was tabulated and subjected to statistical analysis. Results: Majority of participants (40%) belonged to age group 41 to 60 years. There were 60% males and 40% females. The most common frequent cause of intestinal obstruction among the examined patients was adhesive bowel obstruction, followed by obstructed hernia, intussusception and gall stone ileus. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of MDCT on diagnosis of small intestinal obstruction was found to be 100%, 95.65%, 66.67%, 100% and 96.00% respectively. Conclusion: MDCT has high sensitivity and specificity to diagnose and determine the causes of bowel obstruction. It can be used in clinical practice as a modality for detecting intestinal obstruction which can aid in reducing the morbidity and mortality of patients with small intestine obstruction. [ABSTRACT FROM AUTHOR]