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Identification and quantification of an unknown illicit drug (cocaine) from both simulated drug paraphernalia and simulated urine can be achieved via direct analysis in real time (DART) triple quadrupole linear ion trap (QTRAP) mass spectrometry (MS). We describe a novel, hands-on laboratory activity which utilizes the recent DART technology interfaced with a tandem mass spectrometer for the purpose of integrating recent technology into a quantitative analysis course, reinforcing chemical concepts, improving critical thinking and written communication skills, and providing a context for real-life analyses. The hands-on laboratory activity requires students to use good laboratory practice, perform common laboratory calculations, and think critically to perform both qualitative and quantitative analyses and answer real-life forensic questions. Assessments include prelaboratory activity questions, observations during the activity, postlaboratory activity written report, and anonymous summative activity.

Sample handling and laboratory notebook maintenance are necessary skills but can seem abstract if not presented to students in context. An introductory exercise focusing on proper sample handling, data collection and laboratory notebook keeping for the general chemistry laboratory was developed to emphasize the importance of keeping an accurate notebook. The exercise requires minimal technique or prior knowledge, and as such provides students a comfortable introduction to the college laboratory setting. Details of the activity, including preparation, background, procedure, and post-activity instruction, are provided. Alternative uses and application of the activity are also proposed.