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Adolescents and young people living with HIV are at risk of disengaging from HIV care at all stages of the care cascade. Differentiated models of care offer simplified HIV-service delivery options in the hope of improving treatment outcomes, including retention on antiretroviral therapy. However, it remains unclear how successful and widespread these models are for adolescents in sub-Saharan Africa, where the burden of HIV is the greatest. Very few differentiated models of care specifically targeted to adolescents can be found and this priority group are currently ineligible from several models that exist. Where differentiated care has been made available to adolescents, data on the implementation and effectiveness of these interventions remain scarce. Despite this scarcity of evidence on the effectiveness of differentiated care among adolescent populations, several interventions, particularly community-based groups with peer navigators or supporters, might have potential to increase the reach, effectiveness, and adoption of differentiated care in adolescent HIV-care programmes., Competing Interests: Declaration of interests We declare no competing interests. Prof Davies declares grants paid to her institution from the Wellcome Trust, Bill & Melinda Gates Foundation, Viiv Healthcare, and the South African Medical Research Council during the 36 months before initial planning of this work. All other authors declare no competing interests., (Copyright © 2022 Elsevier Ltd. All rights reserved.)