1. Lipodystrophy and serum lipid abnormalities in HIV-positive sub-Saharan population on ART.
- Author
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Filippini P, Scolastico C, Battaglia M, Nacca C, Coppola N, Rossi G, Pisapia R, Martini S, Imparato M, Sagnelli C, Piccinino F, and Sagnelli E
- Subjects
- Adult, Africa South of the Sahara, Anti-HIV Agents adverse effects, Anti-HIV Agents therapeutic use, Case-Control Studies, Drug Therapy, Combination, Female, HIV Protease Inhibitors adverse effects, HIV Protease Inhibitors therapeutic use, HIV Seropositivity drug therapy, HIV Seropositivity ethnology, Humans, Hypercholesterolemia chemically induced, Hypercholesterolemia epidemiology, Hypercholesterolemia ethnology, Hypertriglyceridemia chemically induced, Hypertriglyceridemia epidemiology, Hypertriglyceridemia ethnology, Italy, Male, Middle Aged, Prevalence, Reverse Transcriptase Inhibitors adverse effects, Reverse Transcriptase Inhibitors therapeutic use, White People, Black People, HIV Seropositivity complications, HIV-Associated Lipodystrophy Syndrome chemically induced, HIV-Associated Lipodystrophy Syndrome epidemiology, HIV-Associated Lipodystrophy Syndrome ethnology, Lipids blood
- Abstract
To evaluate whether racial factors may be involved in the development of ART-induced lipodystrophy and/or lipid serum abnormalities, we carried-out a case-control study on all 23 consecutive anti-HIV-positive sub-Saharan black African patients observed from September 20fc01 to December 2001 ('Cases') and 23 Caucasian 'Controls' pair-matched for sex, age (+/-5 years), number of CD4 cells (+/-100 cells), clinical stage of HIV infection, overall duration (+/-3 months) of anti-retroviral treatment and type and duration (+/-3 months) of the last anti-retroviral regimen. The cases, as compared with the controls, less frequently showed lipodystrophy (4.4 vs. 65.2%, P<0.001) and hypertriglyceridemia (8.8 vs. 56.5%, P<0.005), whereas the prevalence of subjects with hypercholesterolemia was similar in the two groups (30 and 39.1%, respectively). Overall, the prevalence of patients lacking both lipodystrophy and serum lipid abnormalities was markedly higher for the cases than for the controls (69.5 vs. 13%, P<0.001). This study seems to indicate that anti-retroviral-induced lipodystrophy and hypertriglyceridemia may be associated to some racial factor.
- Published
- 2006
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