1. Cysteine proteases as potential targets for anti-trypanosomatid drug discovery.
- Author
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Judice, Wagner A.S., Ferraz, Letícia Silva, Lopes, Rayssa de Mello, Vianna, Luan dos Santos, Siqueira, Fábio da Silva, Di Iorio, Juliana F., Dalzoto, Laura de Azevedo Maffeis, Trujilho, Mariana Nascimento Romero, Santos, Taiz dos Reis, Machado, Maurício F.M., and Rodrigues, Tiago
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CYSTEINE proteinases , *NEGLECTED diseases , *PROTOZOAN diseases , *ENDEMIC diseases , *POOR communities , *PROTEOLYTIC enzymes - Abstract
[Display omitted] Leishmaniasis and trypanosomiasis are endemic neglected disease in South America and Africa and considered a significant public health problem, mainly in poor communities. The limitations of the current available therapeutic options, including the lack of specificity, relatively high toxicity, and the drug resistance acquiring, drive the constant search for new targets and therapeutic options. Advances in knowledge of parasite biology have revealed essential enzymes involved in the replication, survival, and pathogenicity of Leishmania and Trypanosoma species. In this scenario, cysteine proteases have drawn the attention of researchers and they are being proposed as promising targets for drug discovery of antiprotozoal drugs. In this systematic review, we will provide an update on drug discovery strategies targeting the cysteine proteases as potential targets for chemotherapy against protozoal neglected diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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