1. Evidence of natural Zika virus infection in neotropical non-human primates in Brazil.
- Author
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Terzian ACB, Zini N, Sacchetto L, Rocha RF, Parra MCP, Del Sarto JL, Dias ACF, Coutinho F, Rayra J, da Silva RA, Costa VV, Fernandes NCCA, Réssio R, Díaz-Delgado J, Guerra J, Cunha MS, Catão-Dias JL, Bittar C, Reis AFN, Santos INPD, Ferreira ACM, Cruz LEAA, Rahal P, Ullmann L, Malossi C, Araújo JP Jr, Widen S, de Rezende IM, Mello É, Pacca CC, Kroon EG, Trindade G, Drumond B, Chiaravalloti-Neto F, Vasilakis N, Teixeira MM, and Nogueira ML
- Subjects
- Aedes virology, Africa, Animals, Brazil, Humans, Phylogeny, Viremia, Zika Virus Infection transmission, Disease Reservoirs virology, Primates virology, Zika Virus pathogenicity, Zika Virus Infection virology
- Abstract
In Africa, Old World Primates are involved in the maintenance of sylvatic circulation of ZIKV. However, in Brazil, the hosts for the sylvatic cycle remain unknown. We hypothesized that free-living NHPs might play a role in urban/periurban ZIKV dynamics, thus we undertook an NHP ZIKV investigation in two cities in Brazil. We identified ZIKV-positive NHPs and sequences obtained were phylogenetically related to the American lineage of ZIKV. Additionally, we inoculated four C. penicillata with ZIKV and our results demonstrated that marmosets had a sustained viremia. The natural and experimental infection of NHPs with ZIKV, support the hypothesis that NHPs may be a vertebrate host in the maintainance of ZIKV transmission/circulation in urban tropical settings. Further studies are needed to understand the role they may play in maintaining the urban cycle of the ZIKV and how they may be a conduit in establishing an enzootic transmission cycle in tropical Latin America.
- Published
- 2018
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