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A high-resolution climate archive was reconstructed based on carbon isotope analysis and radiocarbon dating of the Chapman baobab in northeastern Botswana. The Chapman baobab, which exhibited an open ring-shaped structure composed of six stems, collapsed in January 2016 during an intense El Niño event. Two samples belonging to the oldest stems were investigated in order to obtain a proxy rainfall record, which provides insight into the precipitation regime over the last millennium, evincing centennial and decadal scale variability. The results indicate that the Medieval Warm Period was marked by relatively stable precipitation, whereas rainfall variability and drought frequency increased during the Little Ice Age. The investigated area has experienced both wetter and drier conditions in the past. The wettest conditions of the last millennium were registered before 1450 while the driest period occurred in 1835. For southern Africa, inter-annual rainfall variability is mainly associated with sea surface temperatures in the Agulhas Current core region, which determine the east–west displacement of tropical temperate troughs. Previous studies suggested that positive sea surface temperature anomalies in the Mozambique Channel led to an eastward movement of the troughs but the Chapman record demonstrates a westward displacement in the past, causing drought in northeastern South Africa and wetter conditions in the central part of southern Africa. The positive rainfall correlation with SST anomalies reversed after 1900, causing a gradual decrease in precipitation and confirming the current aridity trend for Botswana. The results contribute to a better understanding of the past climate of southern Africa for which paleoclimate reconstructions remain scarce. [ABSTRACT FROM AUTHOR]

In Sudanese traditional medicine, decoctions of the stem bark of Anogeissus leiocarpa are used for the treatment of tuberculosis (TB). However, this plant has not been investigated before for its antimycobacterial effects. Our screening results show, for the first time, that many extracts of various parts of A. leiocarpa exhibit growth inhibitory activity against Mycobacterium smegmatis. Minimum inhibitory concentration (MIC) values ranged between 625 and 5000 µg/mL, with an ethyl acetate extract of the root showing the lowest MIC value. The good antimycobacterial effects of the root part could be due to its high concentration of ellagic acid derivatives, ellagitannins, and flavonoids. Thin layer chromatography (TLC) fractionation resulted in some fractions with better activity than the starting point crude methanol extract (MIC 2500 µg/mL). Those fractions with the lowest MIC values contained a high number of antioxidant compounds. Fractions 3 and 4 (MIC 1500 and 1000 µg/mL, respectively) contained high concentrations of di-methyl ellagic acid ([M-H]− 329.0318). Fraction 6 (MIC 2000 µg/mL) contained a lower concentration of di-methyl ellagic acid and was not as growth inhibitory as fractions 3 and 4. Moreover, in fraction 3, an acetylated ellagic acid derivative ([M-H]− 343.0477) and di-methyl-ellagic acid xyloside ([M-H]− 461.0739) were tentatively characterized. Di-methyl ellagic acid xyloside was also present in fraction 4 and could strongly contribute to the antimycobacterial effect of this fraction. Additionally, protocatechuic acid ([M-H]− at m/z 153.0196) was present in fraction 4. Our antimycobacterial results obtained from this research justify the use of A. leiocarpa in Sudanese folk medicine against cough related to TB. Roots, stem bark, and leaves of A. leiocarpa are sources for new potent anti-TB drug lead compounds. [ABSTRACT FROM AUTHOR]