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Tropical lands play an important role in the global carbon cycle yet their contribution remains uncertain owing to sparse observations. Satellite observations of atmospheric carbon dioxide (CO2) have greatly increased spatial coverage over tropical regions, providing the potential for improved estimates of terrestrial fluxes. Despite this advancement, the spread among satellite‐based and in‐situ atmospheric CO2 flux inversions over northern tropical Africa (NTA), spanning 0–24°N, remains large. Satellite‐based estimates of an annual source of 0.8–1.45 PgC yr−1 challenge our understanding of tropical and global carbon cycling. Here, we compare posterior mole fractions from the suite of inversions participating in the Orbiting Carbon Observatory 2 (OCO‐2) Version 10 Model Intercomparison Project (v10 MIP) with independent in‐situ airborne observations made over the tropical Atlantic Ocean by the National Aeronautics and Space Administration (NASA) Atmospheric Tomography (ATom) mission during four seasons. We develop emergent constraints on tropical African CO2 fluxes using flux‐concentration relationships defined by the model suite. We find an annual flux of 0.14 ± 0.39 PgC yr−1 (mean and standard deviation) for NTA, 2016–2018. The satellite‐based flux bias suggests a potential positive concentration bias in OCO‐2 B10 and earlier version retrievals over land in NTA during the dry season. Nevertheless, the OCO‐2 observations provide improved flux estimates relative to the in situ observing network at other times of year, indicating stronger uptake in NTA during the wet season than the in‐situ inversion estimates. Plain Language Summary: Satellite carbon dioxide (CO2) observations over land imply a major revision to our understanding of the global carbon cycle linked to large emissions from northern tropical Africa (NTA) during the dry season, from October to May. We use aircraft observations made over the Atlantic Ocean in four seasons to evaluate flux models driven by a range of ground and satellite observations. Our results show that models using satellite observations over land overestimate annual emissions from NTA by approximately 1 PgC yr−1, concentrated in the dry season. At other times of year, satellite CO2 observations provide improved estimates of NTA exchange, with a stronger CO2 uptake during the wet season. Key Points: Emergent constraints derived from aircraft carbon dioxide (CO2) measurements and inversions estimate a near neutral northern tropical African CO2 budgetInversions using satellite observations overestimate annual emissions from northern tropical Africa (NTA) by approximately 1 PgC yr−1Satellite CO2 observations imply a strong sink during the wet season over NTA [ABSTRACT FROM AUTHOR]

The Orbiting Carbon Observatory 2 (OCO-2) satellite has been providing information to estimate carbon dioxide (CO2) fluxes at global and regional scales since 2014 through the combination of CO2 retrievals with top–down atmospheric inversion methods. Column average CO2 dry-air mole fraction retrievals have been constantly improved. A bias correction has been applied in the OCO-2 version 9 retrievals compared to the previous OCO-2 version 7r improving data accuracy and coverage. We study an ensemble of 10 atmospheric inversions all characterized by different transport models, data assimilation algorithms, and prior fluxes using first OCO-2 v7 in 2015–2016 and then OCO-2 version 9 land observations for the longer period 2015–2018. Inversions assimilating in situ (IS) measurements have also been used to provide a baseline against which the satellite-driven results are compared. The time series at different scales (going from global to regional scales) of the models emissions are analyzed and compared to each experiment using either OCO-2 or IS data. We then evaluate the inversion ensemble based on the dataset from the Total Carbon Column Observing Network (TCCON), aircraft, and in situ observations, all independent from assimilated data. While we find a similar constraint of global total carbon emissions between the ensemble spread using IS and both OCO-2 retrievals, differences between the two retrieval versions appear over regional scales and particularly in tropical Africa. A difference in the carbon budget between v7 and v9 is found over this region, which seems to show the impact of corrections applied in retrievals. However, the lack of data in the tropics limits our conclusions, and the estimation of carbon emissions over tropical Africa require further analysis. [ABSTRACT FROM AUTHOR]

Background: Malaria and neglected communicable protozoa parasitic diseases, such as leishmaniasis, and trypanosomiasis, are among the otherwise called diseases for neglected communities, which are habitual in underprivileged populations in developing tropical and subtropical regions of Africa, Asia, and the Americas. Some of the currently available therapeutic drugs have some limitations such as toxicity and questionable efficacy and long treatment period, which have encouraged resistance. These have prompted many researchers to focus on finding new drugs that are safe, effective, and affordable from marine environments. The aim of this review was to show the diversity, structural scaffolds, in-vitro or in-vivo efficacy, and recent progress made in the discovery/isolation of marine natural products (MNPs) with potent bioactivity against malaria, leishmaniasis, and trypanosomiasis. Main text: We searched PubMed and Google scholar using Boolean Operators (AND, OR, and NOT) and the combination of related terms for articles on marine natural products (MNPs) discovery published only in English language from January 2016 to June 2020. Twenty nine articles reported the isolation, identification and antiparasitic activity of the isolated compounds from marine environment. A total of 125 compounds were reported to have been isolated, out of which 45 were newly isolated compounds. These compounds were all isolated from bacteria, a fungus, sponges, algae, a bryozoan, cnidarians and soft corals. In recent years, great progress is being made on anti-malarial drug discovery from marine organisms with the isolation of these potent compounds. Comparably, some of these promising antikinetoplastid MNPs have potency better or similar to conventional drugs and could be developed as both antileishmanial and antitrypanosomal drugs. However, very few of these MNPs have a pharmaceutical destiny due to lack of the following: sustainable production of the bioactive compounds, standard efficient screening methods, knowledge of the mechanism of action, partnerships between researchers and pharmaceutical industries. Conclusions: It is crystal clear that marine organisms are a rich source of antiparasitic compounds, such as alkaloids, terpenoids, peptides, polyketides, terpene, coumarins, steroids, fatty acid derivatives, and lactones. The current and future technological innovation in natural products drug discovery will bolster the drug armamentarium for malaria and neglected tropical diseases. [ABSTRACT FROM AUTHOR]