1. Etiology of severe childhood pneumonia in the Gambia, West Africa, determined by conventional and molecular microbiological analyses of lung and pleural aspirate samples.
- Author
-
Howie SR, Morris GA, Tokarz R, Ebruke BE, Machuka EM, Ideh RC, Chimah O, Secka O, Townend J, Dione M, Oluwalana C, Njie M, Jallow M, Hill PC, Antonio M, Greenwood B, Briese T, Mulholland K, Corrah T, Lipkin WI, and Adegbola RA
- Subjects
- Africa, Western, Bacterial Proteins genetics, Carrier Proteins genetics, Child, Preschool, Coinfection, Gambia, Haemophilus Infections diagnosis, Haemophilus Infections microbiology, Haemophilus influenzae genetics, Humans, Immunoglobulin D genetics, Infant, Lipoproteins genetics, Multilocus Sequence Typing, Pneumococcal Vaccines, Pneumonia, Bacterial diagnostic imaging, Pneumonia, Pneumococcal diagnosis, Pneumonia, Pneumococcal microbiology, Pneumonia, Viral diagnosis, Pneumonia, Viral virology, Polymerase Chain Reaction, Radiography, Serogroup, Streptococcus pneumoniae genetics, Viruses isolation & purification, Haemophilus influenzae isolation & purification, Lung microbiology, Pneumonia, Bacterial diagnosis, Pneumonia, Bacterial microbiology, Streptococcus pneumoniae isolation & purification
- Abstract
Molecular analyses of lung aspirates from Gambian children with severe pneumonia detected pathogens more frequently than did culture and showed a predominance of bacteria, principally Streptococcus pneumoniae, >75% being of serotypes covered by current pneumococcal conjugate vaccines. Multiple pathogens were detected frequently, notably Haemophilus influenzae (mostly nontypeable) together with S. pneumoniae., (© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.)
- Published
- 2014
- Full Text
- View/download PDF