Author: "Chiodi, F." / Region: africa, western - Searchworks@Jio Institute Digital Library Search Results

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Author: Chiodi F, Björling E, Samuelsson A, and Norrby E
Subjects: AIDS Vaccines, Africa, Western epidemiology, Amino Acid Sequence, Animals, Disease Models, Animal, Gene Products, env, Guinea Pigs, HIV Antibodies immunology, HIV Antigens genetics, HIV Envelope Protein gp120 genetics, HIV Infections epidemiology, HIV-1 genetics, HIV-2 genetics, Humans, Molecular Sequence Data, Peptide Fragments genetics, Primates, Sequence Alignment, Sequence Homology, Amino Acid, Simian Immunodeficiency Virus immunology, Vaccination, HIV Antigens immunology, HIV Envelope Protein gp120 immunology, HIV-2 immunology, Peptide Fragments immunology
Published: 1993
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Author: Ljunggren K, Chiodi F, Biberfeld G, Norrby E, Jondal M, and Fenyö EM
Subjects: Africa, Western, Antibodies, Viral isolation & purification, Antibodies, Viral physiology, Antigens, Viral immunology, Humans, Antibody-Dependent Cell Cytotoxicity, Cross Reactions, HIV immunology, Species Specificity
Abstract: Sera from individuals infected with human immunodeficiency virus (HIV) and HIV-related West African viruses can mediate high-titered, virus-specific antibody-dependent cellular cytotoxicity (ADCC) in all stages of infection. No cross-reactive ADCC can be detected between HIV and HIV-related West African strains LAV-2, HTLV-IV, and SBL-6669. Because these two groups of viruses have antigenically distinct envelope glycoproteins, ADCC-mediating antibodies are most likely directed against envelope antigens. For HIV-specific ADCC, this was further confirmed by using sera reacting with HIV envelope but negative for antibodies against viral core antigens.
Published: 1988

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