1. [Renal parenchymatous involvements in African and Caribbean patients with human immunodeficiency virus infection. Apropos of 10 cases].
- Author
-
Cabié A, Matheron S, De Truchis P, Fégueux S, Bouchaud O, Saimot AG, and Coulaud JP
- Subjects
- Adult, Africa, Southern ethnology, Black People, Female, Humans, Kidney pathology, Kidney Diseases pathology, Kidney Diseases physiopathology, Kidney Failure, Chronic etiology, Male, Middle Aged, Proteinuria etiology, Retrospective Studies, Time Factors, West Indies ethnology, Acquired Immunodeficiency Syndrome complications, HIV-1, Kidney Diseases etiology
- Abstract
Between 1989 and 1990, 10 HIV-infected patients with renal involvement (proteinuria and/or renal failure) were followed. The 5 men and 5 women black (4 Haitians, 3 Zairians, 2 Congolese and 1 Angolan). Their mean age was 31.7 +/- 4 years. No known risk factor was identified and transmission was probably heterosexual. When renal disease was diagnosed, 4 patients had AIDS, 5 had ARC and 1 was asymptomatic. Kidney biopsies were performed in 7 patients: 4 HIV-associated nephropathies (HIV AN) with segmental and focal hyalinizations, 1 thrombotic angiopathy, and 2 interstitial nephropathies, 1 with proliferative glomerulonephritis. The clinical, biological and radiographic patterns of 2 of the remaining 3 patients were suggestive of HIV AN. Four of the 6 patients with HIV AN developed end-stage renal disease within 5 +/- 2.5 months; renal function in the other 2 remained stable for 25 and 41 months, respectively, while they were receiving zidovudine, but deteriorated rapidly within weeks of withdrawing this drug. Zidovudine may have delayed the evolution of the nephropathies in these patients.
- Published
- 1993