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The aim of the study, the relationship between coagulation parameters and embryonic loss in embryo transferred (ET) cows and heifers wereevaluated. The animal material of this study consisted of 19 cows and 19 heifers on farms located in East Mediterranean Agriculture Research Institute in Adana. Blood samples were collected before the ET application from the recipient cows and heifers. Coagulation parameters measured included prothrombin time (PT), activated thromboplastin time (APTT), fibrinogen, thrombin time (TT), anti-thrombin-III (AT3) and D-dimer using by Sysmex® CA-7000 and activated protein C resistance, protein C and protein S using by Sysmex CS-5100. The pregnancy rate was found 5/19 (26.3%) and 5/19 (26.3%) in cows and in heifers, respectively (P>0.05). The embryonic mortality ratio in cows was 60% (3/5) and in heifers it was 40% (2/5). The differences of D-dimer levels between pregnant and non-pregnant animals were significant (P<0.05). The APTT levels between the groups with pregnancy and embryonic loss were significantly different (P<0.05). As a result, it was determined that there is a relationship between plasma D-Dimer levels and embryonic loss in cows that were transferred embryo. To the best of authors' knowledge, this is the first study reporting the relationship between coagulation parameters and embryonic loss in ET cows and heifers. [ABSTRACT FROM AUTHOR]