1. Bioactive prenylated xanthones from the young fruits and flowers of Garcinia cowa.
- Author
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Sriyatep T, Siridechakorn I, Maneerat W, Pansanit A, Ritthiwigrom T, Andersen RJ, and Laphookhieo S
- Subjects
- Anti-Bacterial Agents chemistry, Bacillus cereus drug effects, Bacillus subtilis drug effects, Escherichia coli drug effects, Flowers chemistry, Fruit chemistry, Glycoside Hydrolase Inhibitors chemistry, Microbial Sensitivity Tests, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Prenylation, Pseudomonas aeruginosa drug effects, Salmonella typhimurium drug effects, Staphylococcus aureus drug effects, Thailand, Xanthones chemistry, Anti-Bacterial Agents isolation & purification, Anti-Bacterial Agents pharmacology, Garcinia chemistry, Glycoside Hydrolase Inhibitors isolation & purification, Glycoside Hydrolase Inhibitors pharmacology, Xanthones isolation & purification, Xanthones pharmacology, alpha-Glucosidases drug effects
- Abstract
Five new xanthones, garciniacowones A-E (1-5), together with 14 known xanthones, 6-19, were isolated from the young fruits and fresh flowers of Garcinia cowa. The structures of 1-5 were elucidated by analysis of their 1D and 2D NMR spectra and mass spectrometric data. The compounds 1-19 were tested in vitro for their antimicrobial activity and for their ability to inhibit α-glucosidase. Compounds 16 and 17 showed the most potent α-glucosidase inhibitory activity, with IC50 values of 7.8 ± 0.5 and 8.7 ± 0.3 μM, respectively. Compounds 8, 9, and 19 showed antibacterial activity against Bacillus subtilis TISTR 088 with identical MIC values of 2 μg/mL, while 8, 10, and 19 exhibited antibacterial activity against Bacillus cereus TISTR 688 with identical MIC values of 4 μg/mL.
- Published
- 2015
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