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The crystal structures of mixed-ligand sulfato-, selenato-, phosphato-, arsenato-, and chromato-fluoride complexes of uranyl and of mixed-ligand carboxylato-fluoride and mixed-ligand fluoride complexes with neutral donor ligands studied by the single-crystal X-ray diffraction method were systematized and discussed. The crystal chemical features of the structures of the mixed-ligand fluoride complexes of uranyl were determined: the coordination polyhedron of the hexavalent uranium atom in the structures of the mixed-ligand fluoride complexes of uranyl (except for three hexagonal-bipyramidal complexes) has a pentagonal-bipyramidal structure: the oxygen atoms of the uranyl group are located on the vertical axis of the pentagonal bipyramid, perpendicular to the equatorial plane in which five atoms are located. In dimeric and polymeric chains of mixed-ligand fluoride complexes of uranyl (with the exception of one compound in which the common bridge in the dimer complex is oxygen atoms), the uranyl units are linked via fluoride bridges. Inorganic and organic ligands, which contained O-donor atoms, combine dimers and polymer chains into layers and three-dimensional formation. [ABSTRACT FROM AUTHOR]

Two novel mixed-ligand coordination polymers, {[Co(tdc)(btrp)]·0.67DMF}n (1) and {[Zn2(bimb)2(tdc)2]·2H2O}n (2) involving 2,5-thiophenedicarboxylate (H2tdc), and bitopic flexible N-donor ligands, 1,3-bis(1,2,4-triazol-1-yl)propane (btrp) and 1,4-bis((1H-benzo[d]imidazol-1-yl)methyl)benzene (bimb), have been synthesized by the hydrothermal method and characterized via IR, elemental analysis, thermal analysis, and powder X-ray diffraction. The biological functional studies were performed; the treatment activity of the compounds on periodontitis and the specific mechanism was explored. First, the real-time RT-PCR was carried out to determine the inflammatory genes nf-κb and p53 relative expression in periodontal mucosal cells after treating with compounds 1 and 2. Then, the level of the inflammatory cytokine in the gingival crevicular fluid after treating with compounds was also determined by the ELISA detection kit.

Solvothermal reactions of Co(OAc)2·4H2O or Ni(NO3)2·3H2O with 1,4-bis(benzimidazol-1-ylmethyl)-benzene (bmib) ligand and 1,4-terephthalic acid (H2bdc) afforded two 2-dimensional coordination polymers with the chemical formulae of [Co(bmib)(bdc)(H2O)2n (1) and [Ni(bmib)(bdc)(H2O)2n (2). Complexes 1 and 2 were characterized by elemental analysis and single-crystal X-ray diffraction. Furthermore, the anticancer activity of the complexes 1 and 2 was evaluated. Firstly, the CCK-8 assay was performed and MG63 osteogenic sarcoma cell proliferation was determined after complexes 1 and 2 treatment. Next, the Hoechst staining was performed to detect the morphological changes of treated MG63 cells. Subsequently, the western blot was conducted and the apoptotic related protein levels were determined. [ABSTRACT FROM AUTHOR]

In this study, two new mixed-ligand coordination polymers (CPs) {[Cd6(nbta)3(bimb)4(H2O)](H2O)3}n (1, bimb = 4,4′-bis((1H-imidazol-1-yl)methyl)−1,1′-biphenyl) and [Co3(bib)2(nbta)2]n (2, bib = 1,4-bis(benzimidazol-1-yl)−2-butene) have been successfully prepared by reaction of 5-nitro-1,2,3-benzenetricarboxylic acid (H3nbta) with different N-donor ligands under the solvothermal conditions. The as-prepared two CPs have been studied via the elemental analysis along with the single crystal X-ray diffraction. The inhibitory effect of synthesized new mixed-ligand coordination polymers on K562 leukemia cells was evaluated by CCK-8 assay. And the percentage of apoptotic cells after CPs 1 and 2 treatment was assessed by Annexin V-FITC/PI assay. Finally the in vivo effect of CPs on tumor was conducted by tumor volume and mice weight measurement. [ABSTRACT FROM AUTHOR]

Solvothermal reaction of 4,4′-bis(imidazol-1-yl)diphenyl ether (BIDPE) or 1,4-Bis(imidazole-1-ylmethyl)benzene (BiB) with 1,4-benzenedicarboxylic acid (H2bdc) or 4,4'-(thiobis(methylene))dibenzoic acid (H2tba) in the presence of Zn(NO3)2·6H2O or Co(NO3)2·6H2O in a mixed solvent of H2O/DMF yielded two new coordination polymers, namely, [Zn(bdc)(BIDPE)](DMF)2(H2O) (1) and [Co(tba)(BIB)](H2tba)(DMF)(H2O)2 (2). These complexes were characterized by elemental analysis and X-ray single-crystal diffraction, which revealed that complex 1 is a 2D layered network with hexagonal windows while complex 2 is a 1D chain-like structure containing the 0D Co2(BIB)2 loops. Furthermore, the anticancer activity of the two coordination complexes has been evaluated via the CCK-8 assay and western blot assay. [ABSTRACT FROM AUTHOR]

Two new transition metal-based coordination polymers [Zn3(bimb)2(nbta)2]n (1, bimb = 1,4-bis(imidazol-1-yl)-2-butene, H3nbta = 5-nitro-1,2,3-benzenetricarboxylic acid) and {[Cu3(nbta)2(bipp)2(H2O)2](H2O)2}n (2, bipp = 1,4-bis(pyridin-4-ylmethyl)piperazine) have been successfully prepared by reaction of 5-nitro-1,2,3-benzenetricarboxylic acid with the corresponding metal salts and the different N-donor ligands. Furthermore, the treatment effect of compounds 1 and 2 on nephrotic syndrome (NS) was evaluated and the specific mechanism was explored in this research. Firstly, to investigate the level of the Th17 cells and CD4 + CD25 + Foxp3+ regulate cells (Treg) in PBMC was detected with flow cytometry. The RT-PCR was performed to analyze the mRNA expression level of 16sRNA to determine the intestinal flora abundance. [ABSTRACT FROM AUTHOR]

In this study, two new mixed-ligand coordination polymers {[Co(bbi)(tdc)]·5H2O}n (1, bbi = 1,4-bis(imidazolyl)butane) and {[Cu2(bimb)(H2O)(μ3-tdc)2(DMF)2]·H2O}n (2, bimb = 4-bis(1H-imidazol-1-ylmethyl) benzene) were synthesized under the solvothermal conditions via reaction of 2,5-thiophenedicarboxylic acid (H2tdc) with the corresponding metal salts in the existence of different flexible bis-imidazole ligands (bbi for 1 and bimb for 2). The as-prepared two structures were detected via the single crystal X-ray diffraction (SXRD) and then characterized via the analysis of element, powder Xray diffraction (PXRD), thermogravimetric analysis (TGA) as well as infrared (IR) spectroscopy. Furthermore, the protective activity of the compound on the mice with ischemic stroke was evaluated. Firstly, the real time reverse transcription-polymerase chain raction (RT-PCR) was carried out to determine the effect of compounds 1 and 2 against the relative expression level of the glucagon-like peptide 1 receptors (glp1r) on the cerebrovascular endothelial cells. Next, the Morris Water Maze Experiment was also used to detect the improvement function of compounds 1 and 2 on the nice mice cognitive function. [ABSTRACT FROM AUTHOR]

Two novel coordination polymers based on Cu(II) ions as the metal nodes, {Cu(pydc)(2,2‐bpy)(DMF)}n (1, H2pydc=3,5‐pyridinedicarboxylate, 2,2‐bpy=2,2‐bipyridine) and {[Cu(H2O)2(H2imdc)2](H2O)}n (2, H3imdc=1H‐imidazole‐4,5‐dicarboxylic acid) have been synthesized via the hydrothermal or solvothermal conditions and characterized by techniques of elemental analysis, powder X‐ray diffraction (PXRD) as well as the analysis of single‐crystal X‐ray diffraction. Furthermore, the anti‐tumor activities of compounds 1 and 2 against on U251 brain glioma cells were evaluated in vitro. The Cell Counting Kit‐8 (CCK‐8) detection was performed to assess anti‐tumor activities of compounds 1 and 2 on U251 brain glioma cells. The Annexin V‐FITC/PI approach and Terminal deoxynucleotidyl transferase mediated dUTP nick‐end labeling (TUNEL) staining was used to determine the U251 brain glioma cells apoptosis after compounds treatment. Besides, the ROS assay was utilized to determine the ROS accumulation within U251 brain glioma cells after compounds treatment. The RT‐PCR was conducted to measure the ROS related genes relative expression. [ABSTRACT FROM AUTHOR]

Solvothermal reactions of Co(NO3)2·6H2O or Ni(NO3)2·6H2O with 1,4-bis((1H-benzo[d]imidazol-1-yl)methyl)benzene (bimb) and 2,5-thiophenedicarboxylic acid (H2tdc) afforded two three-dimensional coordination polymers with the chemical formulas of [Co2(bimb)2(tdc)2]·2H2O (1) and [Ni2(bimb)2(tdc)2]·2H2O (2). Complexes 1-2 were characterized by elemental analysis and single-crystal X-ray diffraction. To evaluate the anti-proliferation ability of the compounds 1 and 2, the Cell counting kit-8 (CCK-8) assay was performed firstly. After that, the Hoechst staining assay was carried out to determine whether the anti-cancer activity of compound has relationship with the cell apoptosis. Next, the western blot detection of the apoptotic proteins was detected to further prove the effect of compound on cells apoptosis. [ABSTRACT FROM AUTHOR]

Solvothermal reactions of 5-methylisophthalic acid (H2mipa) with 1,4-bis(imidazol-1ylmethyl)benzene (1,4-bib) or 1,3-bis(imidazol-1ylmethyl)benzene (1,3-bib) in the presence of Co(NO3)2·6H2O in a mixed solvent of H2O/DMF yielded two new coordination polymers, namely, [Co2(mipa)(1,4-bib)](H2O) (1) and [Co3(Hmipa)2(mipa)2(1,3-bib)](H2tba)(H2O)2 (2). These complexes were characterized by elemental analysis and X-ray single-crystal diffraction, which reveals that complex 1 is mutually interpenetrated each other to form 3D+3D⟶3D interpenetrated framework with crs/dia-e topology, and complex 2 is constructed from the trinuclear [Co3(COO)6] unit connected by tbip ligands to form 1D structures which were extended to form 2D structures by neutral ligands. Furthermore, the anti-ovarian cancer activity of the two coordination complexes has been evaluated via the Cell Counting Kit-8 (CCK-8) assay and western blot assay. [ABSTRACT FROM AUTHOR]

Micro and nano-structures of a new mixed-ligand Zn(II) fumarate metal-organic polymer, {[Zn(tptz)(fum)].DMF} n ( 1 ), (tptz = 2,4,6-tris(2-pyridyl)-s-triazine, fum = fumarate, DMF = N,N-dimethylforamide), were synthesized by sonochemical method. These new micro and nano-structures were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), IR spectroscopy and elemental analyses. Compound 1 was structurally characterized by single-crystal X-ray diffraction and consists of the primary unit of [Zn(tptz)(fum)]. Self assembly between the units of [Zn(tptz)(fum)] from Zn–O bonds results in the formation of a one-dimensional zinc(II) coordination polymer. The Zn II -ion in compound 1 has ZnO 2 N 3 coordination sphere with a trigonal bipyramidal molecular geometry. Compound 1 was synthesized by ultrasound irradiation under different concentrations and times. The microrods structure of compound 1 with increasing of concentration and ultrasound radiation time were synthesized as nanoparticles structure successfully. So ultrasound radiation change morphology from microrods to nanoparticles. [ABSTRACT FROM AUTHOR]

Highlights: [•] A new Cu coordination polymer with mixed-ligands has been synthesized. [•] The 3D framework was proved by single-crystal X-ray diffraction. [•] Title compound is an unprecedented 3,5-connected ‘ fet’ topological network. [ABSTRACT FROM AUTHOR]

Abstract: Six trinuclear substituted complexes of the type Ru3(CO)9(arphos)(L) were synthesized by a substitution reaction involving Ru3(CO)10(arphos) (1) with L, where L=PCy3, PPh3, P(C6H4F-m)3, P(C6H4F-p)3, P(C6H4Cl-p)3 and PPh(C6H4OMe-p)2, using a thermal method. The structures of the resulting clusters were elucidated by single crystal X-ray diffraction, complemented by means of elemental analysis and spectroscopic methods, including infrared spectroscopy and 1H, 13C{1H} and 31P{1H} NMR spectroscopy. The longest Ru–Ru bond in Ru3(CO)9(arphos)(L) [L=PCy3 (2), P(C6H4F-m)3 (4), P(C6H4F-p)3 (5), P(C6H4Cl-p)3 (6) and PPh(C6H4OMe-p)2 (7)] is the bond that is cis to the monodentate phosphine ligands, while in Ru3(CO)9(arphos)PPh3 (3), the longest bond is the bond that is bridged by the arphos ligand. [Copyright &y& Elsevier]

Abstract: Two 2-(2-benzimidazolyl)-6-methylpyridine (Hbmp) copper(I) complexes bearing PPh3 and 1,4-bis(diphenylphosphino)butane (dppb), namely, [Cu(Hbmp)(PPh3)2](ClO4) (1) and [Cu(Hbmp)(dppb)](ClO4) (2), have been synthesized. X-ray diffraction analysis reveals that the most significant influence of the phosphine ligands on the structures is on the P–Cu–P bond angle. Both two Cu(I) complexes exhibit a weak low-energy absorption at 360–450nm, ascribed to the Cu(I) to Hbmp metal-to-ligand charge-transfer (MLCT) transition, perhaps mixed with some ILCT character inside Hbmp. The room-temperature luminescences are observed for 1 and 2, both in solution and in the solid state, which originate from the MLCT excited states and vary markedly with the phosphine ligands. [Copyright &y& Elsevier]

Abstract: A nano-sized mixed-ligand Cd(II) coordination polymer, {[Cd(bpa)(4,4′-bipy)2(H2O)2](ClO4)2} n (1); bpa=trans-1,2-bis(4-pyridyl)ethane and 4,4′-bipy=4,4′-bipyridine, has been synthesized by a sonochemical method and characterized by IR and 1H NMR spectroscopy. Compound 1 grows in one dimension by two different bridging ligands, 4,4′-bipy and bpa. The thermal stability of compound 1 in the bulk form and nano-sized was studied by thermogravimetric (TG) and differential thermal analysis (DTA). The crystallinity of this compound was studied by X-ray powder diffraction and compared with an XRD simulation of the single crystal data. CdO nanoparticles were obtained by direct calcination at 500°C and decomposition in oleic acid at 200°C of the nano-sized compound 1. The obtained cadmium(II) oxide nano-particles were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). [Copyright &y& Elsevier]

Abstract: Two novel mixed-ligand dicopper(I) halide complexes, [{Cu(PPh3)X}2(μ-HL)] (HL=3,5-bis{6-(2,2′-dipyridyl)}pyrazole, X=I (1); Br (2)), have been synthesized by a straightforward double-layer diffusion approach and structurally characterized by single-crystal X-ray diffraction. The multi-site HL acts as a bridging bis-bidentate chelate, assembling two Cu(PPh3)X moieties into copper(I) dimers possessing the triple-decker “organic” sandwich structure of phenyl/pyrazolyl/phenyl through π···π interactions. Complexes 1 and 2 exhibit photoluminescence in the solid state at ambient temperature, ascribed to a combination of intraligand charge transfer (ILCT) and metal-to-ligand charge transfer (MLCT) transitions. The emission of 2 is red-shifted 18nm relative to that of 1 due to substitution of the iodides of 1 by the weaker electron-donating bromides. [Copyright &y& Elsevier]

Abstract: In order to deepen our understanding of the versatile behaviour of adenine (Hade) as ligand, we have synthesized four novel ternary copper(II) complexes having two deazaadenine ligands, namely 4-azabenzimidazole (H4abim) or 7-azaindole (H7azain) as N1,N6-dideazaadenine or N1,N6,N7-trideazaadenine, respectively. The related compounds were studied by thermal, spectral and single crystal X-ray diffraction methods. In [Cu(NBzIDA)(H4abim)] n (1) the recognition between H4abim and the (N-benzyliminodiacetate)-copper(II) chelate only displays the formation of the Cu–N7(purine-like) bond, in contrast to Hade behaviour in [Cu(NBzIDA-like)(Hade)(H2O)]·H2O (Cu–N3(Hade) bond reinforced by N9–H···O(IDA-like) interaction). In [Cu(EIDA)(H7azain)(H2O)] (2, EIDA= N-ethyliminodiacetate ligand), [Cu(NBzIDA)(H7azain)(H2O)] (3) and [Cu(μ2-SO4)(H7azain)2(H2O)2] n (4), H7azain binds Cu(II) centre by the Cu–N3(purine-like) bond, reinforced by a N9–H···O(IDA-like or sulfate) intra-molecular interligand interaction. [Copyright &y& Elsevier]

Abstract: Three new metal–organic frameworks, [Zn(atz)(nic)] n (1), [Zn(atz)(isonic)] n ·nHisonic(2) and [Cd(atz)(isonic)] n (3) (Hnic=nicotinic acid, Hisonic=isonicotinic acid), have been firstly synthesized by employing mixed-ligand of pyridinecarboxylate with the in situ generated ligand of 5-amino-tetrazolate(atz−), and characterized by elemental analysis, IR spectroscopy, TGA and single crystal X-ray diffraction. The results revealed that 1 presents a two-dimensional (2D) “sql” topological network constructed from the linear chain subunit of Zn(nic)2 and atz− ligand. A remarkable feature of 2 is a 2-fold interpenetrated diamondoid network with free Hisonic molecules locating in the channels formed by the zigzag chain subunits of Zn(isonic)2. Complex 3 is a 3D non-interpenetrated pillared framework constructed from the double chain subunits of Cd–COO−–Cd. It possesses a rarely observed (4,6)-connected “fsc” topology. The thermal stabilities and fluorescent properties of the complexes were investigated. All of these complexes exhibited intense fluorescent emissions in the solid state at room temperature. [Copyright &y& Elsevier]

Abstract: A novel one-dimensional Wells–Dawson-based compound H2(bbi)0.5[Ni(phen)(bbi)2]2[P2W18O62] (phen=1,10′-phenanthroline, bbi=1,1′-(1,4-butanediyl)bis(imidazole)), has been prepared under the hydrothermal conditions and structurally characterized by elemental analysis, cyclic voltammetry, IR and XPS spectra and single-crystal X-ray diffraction. The title compound exhibits an interesting wavelike chain constructed from Dawson type polyoxoanion and mixed rigid and flexible ligands decorated [Ni(phen)(bbi)2]2+ cationic complex. It represents the first example of polyoxometalate that built from the rigid and flexible ligands at the same time. [Copyright &y& Elsevier]

Abstract: A novel supramolecular mixed ligand complex of formula [Co(Phmal)(Him)4] (Phmal=phenylmalonate, Him=imidazole) has been synthesized and characterized by FT-IR spectroscopy, thermogravimetric analysis (TG), UV-Vis spectra. X-ray crystallographic studies of the complex reveal that the cobalt atom exhibits a distorted octahedral geometry being coordinated by four nitrogen atoms of Him ligands, two oxygen atoms from the phenylmalonate ligand. The intramolecular C–H⋯π interaction exists in the title complex. The three dimensional supramolecular network is constructed from the strong intermolecular N–H⋯O hydrogen bonds. [Copyright &y& Elsevier]