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Background: It has been proven that there is an increase in intestinal permeability in some autoimmune diseases. In our study, we purposed to assess intestinal permeability in vitiligo disease by looking at zonulin levels. At the same time, we aimed to examine the correlation of inflammatory cytokines and lipopolysaccharide (LPS) levels with zonulin., Methods: Forty-one patients and 41 healthy participants were involved in our study. Blood samples were taken from all patients and controls, and the levels of zonulin, tumor necrosis factor (TNF)-α, interleukin (IL)-6 and LPS were examined., Results: The mean of zonulin in the patient group was found to be statistically higher than the control group (p < 0.05). A positive correlation was found between zonulin level and IL-6, TNF-α, and LPS levels (p < 0.05). TNF-α and LPS levels in the vitiligo group were significantly higher than in the control group, but there was no such significance in terms of IL-6 levels., Conclusion: We think that serum zonulin level increases and intestinal permeability increases in vitiligo disease., (© 2022 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.)

Vitiligo is a pigment disease characterized by the disruption of melanocyte structure and function. Its etiology is unknown; however, genetic predisposition, biochemical factors, and neural mechanisms are thought to be effective. Although many agents are being used for its treatment, generally there is no absolute cure. The aim of the present study is to evaluate the effectiveness of topical Nigella sativa seed oil on vitiligo patients. Thirty-three vitiligo patients were included in the study. Totally 47 areas were evaluated in all patients. Cream containing N sativa seed oil was topically applied to hands, face, and genital region two times a day for 6 months. Statistically significant repigmentation was detected in hands, face, and genital region, the three treatment areas, and the p values are found .005, .001, and .004, respectively. N sativa can be used as an adjuvant therapy that can contribute to the treatment especially in sensitive skin areas like genital region., (© 2019 Wiley Periodicals, Inc.)

Aim: Vitiligo is an acquired disease with loss of melanocytes, etiology of which is unclear. The aim of this study is to determine the role of systemic inflammation in vitiligo by measuring the Neutrophil-Lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) markers included in routine hemogram test, in patients with vitiligo. Material and Methods: The study was carried out by reviewing the data of patients who applied to İnönü University Faculty of Medicine Dermatology Polyclinic and diagnosed with vitiligo after Wood's lamp examination, between July 2012 and February 2018. The study was performed retrospectively by reviewing patient files and ethics committee approval was not obtained. Results: A total of 170 individuals including 79 vitiligo patients and 91 healthy individuals were included in the study. When the vitiligo patients and healthy control group were compared in terms of routine hemogram parameters, statistically significant differences were found in terms of erythrocyte distribution width (RDW), but there were no statistically significant differences in terms of NLR, PLR, lymphocyte, neutrophil, platelets and White bloodcell (WBC) counts. Conclusion: In our study, only RDW value was found to be higher in patients with vitiligo compared to healthy controls, and no difference was found in other parameters indicating systemic inflammation. [ABSTRACT FROM AUTHOR]