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Your search keyword '"Rodo, M."' showing total 3 results
Start Over Author "Rodo, M." Topic vitamin e
3 results on '"Rodo, M."'

1. The level of serum lipids, vitamin E and low density lipoprotein oxidation in Wilson's disease patients.

Author

Rodo M, Czonkowska A, Pulawska M, Swiderska M, Tarnacka B, and Wehr H

Subjects
Adult, Cholesterol blood, Copper blood, Hepatolenticular Degeneration drug therapy, Humans, Lipid Peroxidation physiology, Middle Aged, Penicillamine administration & dosage, Treatment Outcome, Triglycerides blood, Zinc Sulfate administration & dosage, Hepatolenticular Degeneration blood, Lipoproteins, LDL blood, Vitamin E blood
Abstract

Unlabelled: The aim of this study was to estimate the level of lipids and of the main serum antioxidant, alpha-tocopherol (vitamin E), and to evaluate the susceptibility of low density lipoprotein (LDL) to oxidation in Wilson's disease patients. It was assumed that enhanced LDL peroxidation caused by high copper levels could contribute to the injury of liver and other tissues. The group investigated comprised 45 individuals with Wilson's disease treated with penicillamine or zinc salts and a control group of 36 healthy individuals. Lipids were determined by enzymatic methods, alpha-tocopherol by high performance liquid chromatography, the susceptibility of LDL to oxidation in vitro by absorption changes at 234 nm during 5 h and end-products of LDL lipid oxidation as thiobarbituric acid reacting substances. In Wilson's disease patients total cholesterol, LDL cholesterol and alpha-tocopherol levels were significantly lower compared with the control group. No difference in LDL oxidation in vitro between the patients and the controls was stated., Conclusion: enhanced susceptibility of isolated LDL for lipid peroxidation in vitro was not observed in Wilson's disease patients. One cannot exclude, however, that because of low alpha-tocopherol level lipid peroxidation in the tissues can play a role in the pathogenesis of tissue injury in this disease.

Published
2000
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2. Dynamics of LDL oxidation in ischemic stroke patients

Author

Barańska-Gieruszczak M, Wehr H, Rodo M, M. Roszczynko, Szirkowiec W, Ryglewicz D, and M. Swiderska

Subjects
medicine.medical_specialty, business.industry, Vascular disease, Vitamin E, medicine.medical_treatment, Ischemia, General Medicine, Oxidative phosphorylation, medicine.disease, Pathophysiology, Central nervous system disease, chemistry.chemical_compound, Endocrinology, Neurology, chemistry, Internal medicine, Low-density lipoprotein, medicine, lipids (amino acids, peptides, and proteins), Neurology (clinical), business, Stroke
Abstract

Objective – Oxidative modification of human low density lipoprotein (LDL) plays an important role in the development of atherosclerosis. The aim of this study was to evaluate the oxidative modification of LDL in the group of patients with ischemic stroke. Material and methods – In the group of 43 patients 3 months after ischemic stroke and in the age and sex-matched control group, the kinetics of LDL oxidation and level of vitamin E were estimated. The susceptibility of LDL to oxidation was evaluated in isolated LDL exposed to in vitro oxidation. In 26 patients, after diet change, clinical and laboratory investigations were repeated 9 months later. Results – In the patient group, susceptibility of LDL to oxidation was enhanced, lag phase was significantly shorter in comparison with the control group. After a change in diet, significant elongation of the lag phase was observed. Conclusion – Diet change improves LDL resistance to oxidation and may influence prognosis in stroke patients.

Published
2002
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3. The level of serum lipids, vitamin E and low density lipoprotein oxidation in Wilson's disease patients

Author

M. Swiderska, Rodo M, M. Pulawska, A. Czonkowska, H. Wehr, and B. Tarnacka

Subjects
Adult, medicine.medical_specialty, Antioxidant, Thiobarbituric acid, medicine.medical_treatment, Blood lipids, Lipid peroxidation, chemistry.chemical_compound, Hepatolenticular Degeneration, Lipid oxidation, Internal medicine, medicine, Humans, Vitamin E, Triglycerides, business.industry, Penicillamine, Middle Aged, medicine.disease, Zinc Sulfate, Lipoproteins, LDL, Wilson's disease, Cholesterol, Treatment Outcome, Endocrinology, Neurology, chemistry, Low-density lipoprotein, Immunology, lipids (amino acids, peptides, and proteins), Lipid Peroxidation, Neurology (clinical), business, Copper
Abstract

UNLABELLED The aim of this study was to estimate the level of lipids and of the main serum antioxidant, alpha-tocopherol (vitamin E), and to evaluate the susceptibility of low density lipoprotein (LDL) to oxidation in Wilson's disease patients. It was assumed that enhanced LDL peroxidation caused by high copper levels could contribute to the injury of liver and other tissues. The group investigated comprised 45 individuals with Wilson's disease treated with penicillamine or zinc salts and a control group of 36 healthy individuals. Lipids were determined by enzymatic methods, alpha-tocopherol by high performance liquid chromatography, the susceptibility of LDL to oxidation in vitro by absorption changes at 234 nm during 5 h and end-products of LDL lipid oxidation as thiobarbituric acid reacting substances. In Wilson's disease patients total cholesterol, LDL cholesterol and alpha-tocopherol levels were significantly lower compared with the control group. No difference in LDL oxidation in vitro between the patients and the controls was stated. CONCLUSION enhanced susceptibility of isolated LDL for lipid peroxidation in vitro was not observed in Wilson's disease patients. One cannot exclude, however, that because of low alpha-tocopherol level lipid peroxidation in the tissues can play a role in the pathogenesis of tissue injury in this disease.

Published
2000
Full Text
View/download PDF

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