1. Pain Severity and Vitamin D Deficiency in IBD Patients.
- Author
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Frigstad SO, Høivik ML, Jahnsen J, Cvancarova M, Grimstad T, Berset IP, Huppertz-Hauss G, Hovde Ø, Bernklev T, Moum B, and Jelsness-Jørgensen LP
- Subjects
- Adolescent, Adult, Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Norway epidemiology, Pain Measurement, Young Adult, Inflammatory Bowel Diseases complications, Inflammatory Bowel Diseases epidemiology, Pain complications, Pain epidemiology, Pain physiopathology, Vitamin D Deficiency complications, Vitamin D Deficiency epidemiology
- Abstract
Background : Pain and vitamin D deficiency are common in inflammatory bowel disease (IBD). Disease activity, fatigue, frequent relapses, prior surgery and psychological factors all seem to influence the experience of pain in IBD. Vitamin D deficiency has been associated with muscle and skeletal pain. This study aimed to determine whether there is an association between vitamin D deficiency and severity of pain in patients with IBD, and to investigate the influence of other socio-demographic and psychological variables on the experience of pain. Methods : Patients with IBD were recruited from nine hospitals in Norway in a multicenter cross-sectional study. The Brief Pain Inventory (BPI) questionnaire was used to measure pain. Disease activity was assessed using clinical disease activity indices, C-reactive protein (CRP) and fecal calprotectin. Regression models were fitted to explore a possible association between 25-hydroxyvitamin D and pain severity. Results : Of 407 patients included in the analyses, 229 (56%) had Crohn's disease (CD) and 178 (44%) had ulcerative colitis (UC). Vitamin D deficiency was present in half (203/407) of patients. Presence of pain was reported by 76% (309/407). More severe pain was associated with female gender and increased disease activity scores, but not with increased CRP or fecal calprotectin. In CD, patients without prior intra-abdominal surgery reported more severe pain. In multivariate analyses, there was no association between 25-hydroxyvitamin D and pain severity. Conclusions : In this study, no significant association between pain severity and vitamin D deficiency was revealed in patients with IBD., Competing Interests: Frigstad SO reports a research grant from Pharmacosmos AS, during the conduct of the study; personal fees from Tillotts Pharma, Pharmacosmos AS, Janssen-Cilag, Pfizer, Takeda, Intercept Pharma, and Abbvie, outside the submitted work. Høivik ML reports personal fees from MSD, Tillotts Pharma, Abbvie, Takeda and MEDA, outside the submitted work, and investigator initiated research grants, outside the submitted work. Jelsness-Jørgensen LP reports an unrestricted research grant from Tillotts Pharma, during the conduct of the study. The other authors state no conflicts of interest.
- Published
- 2019
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