1. Investigations on topically applied vitamin A loaded amphiphilic cyclodextrin nanocapsules.
- Author
-
Weisse S, Kalimouttou S, Lahiani-Skiba M, Djedaini-Pilard F, Perly B, and Skiba M
- Subjects
- Administration, Topical, Crystallization methods, Drug Compounding methods, Humans, Hydrophobic and Hydrophilic Interactions, In Vitro Techniques, Macromolecular Substances chemistry, Materials Testing, Molecular Conformation, Nanostructures ultrastructure, Nanotechnology methods, Particle Size, Surface Properties, Cyclodextrins chemistry, Drug Carriers chemistry, Nanostructures chemistry, Skin metabolism, Vitamin A administration & dosage, Vitamin A chemistry
- Abstract
A new cholesteryl-cyclodextrin derivative, obtained by grafting a single cholesterol on a cyclodextrin, was proved suitable for the manufacture of nanocapsules. The chemical structure of Chol-betaCD-Ac was assessed using high resolution 1H-NMR. These nanocapsules were loaded with a lipophilic drug, i.e., vitamin A propionate (PRVA) which is a highly unstable and poorly water soluble molecule with a real interest in therapeutic. The oily nature of vitamin A propionate leads to the formation of nanocapsules with a reproductible size distribution and a long term stability. The colloidal suspension can be used to form a gel which allow to achieve penetration in the skin of the PRVA encapsulated.
- Published
- 2009
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