1. Correlation between retinal sensitivity and retinal vascular perfusion after idiopathic epiretinal membrane peeling.
- Author
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Nicolai M, Franceschi A, De Turris S, Rosati A, Carpenè MJ, Danieli L, Lassandro NV, Pelliccioni P, Lupidi M, and Mariotti C
- Subjects
- Humans, Female, Male, Prospective Studies, Aged, Middle Aged, Visual Field Tests, Retina physiopathology, Retina diagnostic imaging, Visual Fields physiology, Regional Blood Flow physiology, Epiretinal Membrane physiopathology, Epiretinal Membrane surgery, Visual Acuity physiology, Tomography, Optical Coherence, Retinal Vessels physiopathology, Retinal Vessels diagnostic imaging, Vitrectomy
- Abstract
Background: To evaluate the correlations between anatomical and functional changes after idiopathic epiretinal membrane (iERM) surgery., Methods: In this prospective, observational, single-center study, consecutive patients who underwent iERM peeling were enrolled. Reported data were pre- and postoperative best-corrected visual acuity (BCVA), retinal sensitivity (RS) and fixation stability values on microperimetry, structural macular features on SD-OCT and OCTA. RS of foveal and parafoveal area was analysed and two sub-groups were identified whether RS improved or remained unchanged/worsened after surgery; consequently, vascular perfusion density (VPD) of the same area was studied., Results: Twenty-nine eyes of 29 patients were examined. The post-operative improvement in terms of BCVA, RS and fixation within the central 4 degrees was significant (p < 0.001, p < 0.001, p = 0.001), as well as the foveal thickness and macular volume change/reduction (p < 0.001). The pre-operative superficial VPD, choriocapillaris VPD and capillary free zone (CFZ) area were significantly reduced compared to the fellow healthy eye (p = 0.001, p = 0.02, p < 0.001). Choriocapillaris VPD showed a statistically significant increase after surgery (p < 0.02). Superficial, deep and choriocapillaris VPD of the improved RS group showed a significant increase both in foveal (p = 0.03, p = 0.03, p = 0.01) and parafoveal areas (p = 0.01, p = 0.03, p = 0.001)., Conclusions: We reported a higher VPD in the retinal area that experienced a retinal sensitivity improvement 6 months after ERM surgery. This result objectifies the tight bond between visual function and retinal perfusion in ERM patients., Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
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