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3 results on '"G. Costagliola"'

1. Nutraceuticals in Viral Infections: An Overview of the Immunomodulating Properties.

Author

Costagliola G, Nuzzi G, Spada E, Comberiati P, Verduci E, and Peroni DG

Subjects
Animals, Antiviral Agents adverse effects, Host-Pathogen Interactions, Humans, Immune System immunology, Immune System metabolism, Immune System virology, Immunologic Factors adverse effects, Treatment Outcome, Virus Diseases immunology, Virus Diseases metabolism, Virus Diseases virology, Viruses immunology, Viruses pathogenicity, Antiviral Agents therapeutic use, Dietary Supplements adverse effects, Immune System drug effects, Immunologic Factors therapeutic use, Virus Diseases drug therapy, Viruses drug effects
Abstract

Nutraceuticals, including vitamin D, vitamin A, zinc, lactoferrin, polyphenols coenzyme Q, magnesium, and selenium, are implicated in the modulation of the complex molecular pathways involved in the immune response against viral pathogens. A common element of the activity of nutraceuticals is their ability to enhance the innate immune response against pathogens by acting on the major cellular subsets and inducing the release of pro-inflammatory cytokines and antimicrobial peptides. In some cases, this action is accompanied by a direct antimicrobial effect, as evidenced in the specific case of lactoferrin. Furthermore, nutraceuticals act through complex molecular mechanisms to minimize the damage caused by the activation of the immune system against pathogens, reducing the oxidative damage, influencing the antigen presentation, enhancing the differentiation and proliferation of regulatory T cells, driving the differentiation of lymphocyte subsets, and modulating the production of pro-inflammatory cytokines. In this paper, we review the main molecular mechanisms responsible for the immunomodulatory function of nutraceuticals, focusing on the most relevant aspects for the prevention and treatment of viral infections.

Published
2021
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2. CD4 T cell decline following HIV seroconversion in individuals with and without CXCR4-tropic virus

Author

Ghosn, J. Bayan, T. Meixenberger, K. Tran, L. Frange, P. Monforte, A.A. Zangerle, R. de Mendoza, C. Krastinova, E. Porter, K. Meyer, L. Chaix, M.-L. Burns, F. Chene, G. Costagliola, D. Giaquinto, C. Grarup, J. Kirk, O. Meyer, L. Bailey, H. Anne, A.V. Panteleev, A. Phillips, A. Thorne, C. Aboulker, J.-P. Albert, J. Asandi, S. Cene, G. Costagliola, D. Monforte, A. De Wit, S. Reiss, P. Del Amo, J. Gatell, J. Giaquinto, C. Hamouda, O. Karpov, I. Ledergerber, B. Lundgren, J. Malyuta, R. Møller, C. Prins, M. Rakhmanova, A. Rockstroh, J. Rosinska, M. Sandhu, M. Thorne, C. Touloumi, G. Anne, A.V. Dedes, N. Fenton, K. Pizzuti, D. Vitoria, M. Fradette, L. Frost, R. Cartier, A. Raben, D. Schwimmer, C. Scott, M. on behalf of the CASCADE Collaboration in EuroCoord

Subjects
viruses, virus diseases
Abstract

Background: THe natural clinical and immunological courses following HIV seroconversion with CXCR4-tropic or dual-mixed (X4/DM) viruses are controversial. We compared spontaneous immunological outcome in patients harbouring an X4/DM virus at the time of seroconversion with those harbouring a CCR5-tropic (R5) virus. Methods: Data were included from patients participating in CASCADE, a large cohort collaboration of HIV seroconverters, with ≥ 2 years of follow-up since seroconversion. The HIV envelope gene was sequenced from frozen plasma samples collected at enrolment, and HIV tropismwas determined using Geno 2Pheno (false-positive rate 10%). The spontaneous CD4 T cell evolution was compared by modelling CD4 kinetics using linear mixed-effects models with random intercept and random slope. Results: A total of 1387 patients were eligible. Median time between seroconversion and enrolment was 1month (range 0-3). At enrolment, 202 of 1387 (15%) harboured an X4/DM-tropic virus. CD4 decrease slopes were not significantly different according to HIV-1 tropism during the first 30months after seroconversion. No marked change in these results was found after adjusting for age, year of seroconversion and baseline HIV viral load. Time to antiretroviral treatment initiation was not statistically different between patients harbouring an R5 (20.76months) and those harbouring an X4/DM-tropic virus (22.86months, logrank test P"0.32). Conclusions: In this large cohort collaboration, 15% of the patients harboured an X4/DM virus close to HIV seroconversion. Patients harbouring X4/DM-tropic viruses close to seroconversion did not have an increased risk of disease progression, estimated by the decline in CD4 T cell count or time to combined ART initiation.

Published
2017

3. High Levels of Alcohol Consumption Increase the Risk of Advanced Hepatic Fibrosis in HIV/Hepatitis C Virus-Coinfected Patients: A Sex-Based Analysis Using Transient Elastography at Enrollment in the HEPAVIH ANRS CO13 Cohort

Author

Maria Patrizia Carrieri, Caroline Lions, François Dabis, Bruno Spire, Perrine Roux, Marc-Arthur Loko, Aurore Caumont-Prim, Dominique Salmon-Ceron, Fabienne Marcellin, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] (ORS PACA), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Maladies Infectieuses et Tropicales [AP-HP Hôpital Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5), This work was supported by the ANRS, with the participation of Abbott France, GlaxoSmithKline, Roche, Schering-Plough, and INSERM’s 'Programme Cohortes TGIR.', HEPAVIH (ANRS CO13) Study Group : Salmon D, Dabis F, Winnock M, Loko M, Sogni P, Benhamou Y, Trimoulet P, Izopet J, Paradis V, Spire B, Carrieri P, Katlama C, Pialoux G, Valantin M, Bonnard P, Poizot-Martin I, Marchou B, Rosenthal E, Garipuy D, Bouchaud O, Gervais A, Lascoux-Combe C, Goujard C, Lacombe K, Duvivier C, Vittecoq D, Neau D, Morlat P, BaniSadr F, Meyer L, Boufassa F, Dominguez S, Autran B, Roque A, Solas C, Fontaine H, Serfaty L, Chêne G, Costagliola D, Couffin-Cadiergues S, Salmon D, Chakvetadze E, Sogni P, Terris B, Makhlouf Z, Dubost G, Tessier F, Gibault L, Beuvon F, Chambon E, Lazure T, Krivine A, Katlama C, Valantin MA, Stitou H, Benhamou Y, Charlotte F, Fourati S, Poizot-Martin I, Zaegel O, Ménard A, Pialoux G, Bonnard P, Bani-Sadr F, Slama L, Lyavanc T, Callard P, Bendjaballah F, Le-Pendeven C, Marchou B, Alric L, Barange K, Metivier S, Selves J, Nicot F, Rosenthal E, Durant J, Haudebourg J, Saint-Paul M, Bouchaud O, Rouges F, Djebbar R, Ziol M, Baazia Y, Uzan M, Bicart-See A, Garipuy D, Selves J, Nicot F, Yéni P, Gervais A, Adle-Biassette H, Séréni D, Lascoux Combe C, Bertheau P, Duclos J, Palmer P, Girard P, Lacombe K, Campa P, Wendum D, Cervera P, Adam J, Harchi N, Delfraissy JF, Goujard C, Quertainmont Y, Pallier C, Vittecoq D, Lortholary O, Duvivier C, Shoai-Tehrani M, Neau D, Morlat P, Lacaze-Buzy L, Caldato S, Bioulac-Sage P, Trimoulet P, Reigadas S, Beniken D, Ritleng AS, Fooladi A, Azar M, Honoré P, Breau S, Serini L, Mole M, Bolliot C, Touam F, André F, Ouabdesselam N, Mellul S, Alexandre G, Ganon A, Champetier A, Gillet S, Delaune J, Dequae Merchadou L, Pambrun E, Frosch A, Cohen J, Kurkdji P, Loko M, Winnock M., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Université Bordeaux Segalen - Bordeaux 2, and Dupuis, Christine

Subjects
Microbiology (medical), Pathology, medicine.medical_specialty, viruses, Hepatitis C virus, education, Human immunodeficiency virus (HIV), medicine.disease_cause, complex mixtures, Gastroenterology, fluids and secretions, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Internal medicine, mental disorders, medicine, business.industry, 3. Good health, Infectious Diseases, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Cohort, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Transient elastography, Hepatic fibrosis, business, Alcohol consumption
Abstract

International audience; Comment in Reply to Marcellin et al. [Clin Infect Dis. 2014]Comment on Relationship between alcohol use categories and noninvasive markers of advanced hepatic fibrosis in HIV-infected, chronic hepatitis C virus-infected, and uninfected patients. [Clin Infect Dis. 2014]

Published
2014
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