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1. Mutations at positions 186 and 194 in the HA geneof the 2009 H1N1 pandemic influenza virusimprove replication in cell culture and eggs.

Author

Suphaphiphat, Pirada, Franti, Michael, Hekele, Armin, Lilja, Anders, Spencer, Terika, Settembre, Ethan, Palmer, Gene, Crotta, Stefania, Tuccino, Annunziata B., Keiner, Bjoern, Trusheim, Heidi, Balabanis, Kara, Sackal, Melissa, Rothfeder, Mithra, Mandl, Christian W., Dormitzer, Philip R., and Mason, Peter W.

Subjects
INFLUENZA A virus, H1N1 subtype, MICROORGANISMS, MICROBIOLOGY, VIRUS diseases, INFLUENZA
Abstract

Obtaining suitable seed viruses for influenza vaccines poses a challenge for public health authorities and manufacturers. We used reverse genetics to generate vaccine seed-compatible viruses from the 2009 pandemic swine-origin influenza virus. Comparison of viruses recovered with variations in residues 186 and 194 (based on the H3 numbering system) of the viral hemagglutinin showed that these viruses differed with respect to their ability to grow in eggs and cultured cells. Thus, we have demonstrated that molecular cloning of members of a quasispecies can help in selection of seed viruses for vaccine manufacture. [ABSTRACT FROM AUTHOR]

Published
2010
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