1. Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs.
- Author
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Salat J, Hunady M, Svoboda P, Strelcova L, Strakova P, Fortova A, Palus M, and Ruzek D
- Subjects
- Humans, Animals, Dogs, Mice, Antibodies, Viral, Vaccination, Immunization, Encephalitis, Tick-Borne prevention & control, Encephalitis, Tick-Borne veterinary, Viral Vaccines, Encephalitis Viruses, Tick-Borne
- Abstract
Tick-borne encephalitis (TBE) is a severe neuroinfection of humans. Dogs are also commonly infected with tick-borne encephalitis virus (TBEV). These infections are usually asymptomatic, but sometimes show clinical signs similar to those seen in humans and can be fatal. To date, there is no TBEV vaccine available for use in dogs. To address this need, a TBEV vaccine candidate for dogs based on inactivated whole virus antigen was developed. The safety, immunogenicity, and efficacy of the vaccine candidate were tested in mice as the preclinical model and in dogs as the target organism. The vaccine was well tolerated in both species and elicited the production of specific anti-TBEV antibodies with virus neutralising activity. Vaccination of mice provided complete protection against the development of fatal TBE. Immunisation of dogs prevented the development of viremia after challenge infection. Therefore, the developed vaccine candidate is promising to protect dogs from severe TBEV infections., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jiri Salat and Milan Hunady report financial support that was provided by Ministry of Industry and Trade of the Czech Republic. Daniel Ruzek reports financial support that was provided by EEA Grants. Daniel Ruzek reports financial support that was provided by European Union. Milan Hunady reports a relationship with Bioveta as that includes: employment. Lucie Strelcova reports a relationship with Bioveta as that includes: employment. Milan Hunady, Daniel Ruzek, Jiri Salat has patent #31355 issued to Utility model issued by the Industrial Property Office, Prague, Czech Republic., (Copyright © 2023 Elsevier Ltd. All rights reserved.)
- Published
- 2023
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