7 results on '"Binh, Nguyen Thanh"'
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2. HCV RNA Quantification by a Domestic Commercial Assay: A Case Study among People Who Inject Drugs in Vietnam
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Quynh Bach Thi Nhu, Linh Le Thi Thuy, Hong Thi Nguyen, Binh Nguyen Thanh, Delphine Rapoud, Catherine Quillet, Hong Thi Tran, Roselyne Vallo, Thanh Nham Thi Tuyet, Laurent Michel, Laurence Weiss, Philippe Vande Perre, Vinh Vu Hai, Nicolas Nagot, Oanh Khuat Thi Hai, Don Des Jarlais, Huong Thi Duong, Khue Pham Minh, Didier Laureillard, and Jean-Pierre Molès
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diagnostic ,HCV ,drug users ,Vietnam ,assays ,Medicine (General) ,R5-920 - Abstract
The desired performance of nucleic acid testing (NAT) may vary if used for disease diagnosis or for the evaluation of the therapeutic efficacy of a treatment, although in most cases, the same assay is used. However, these tests may not be affordable in many situations including in low/middle income countries that in response have developed domestic assays. Given the example of HCV NAT among people who inject drugs in Vietnam, we aimed at evaluating a domestic assay versus an FDA- and CE-approved assay. This cross-evaluation revealed that (i) the domestic assay had a poorer sensitivity with a threshold of detection above 104 IU/mL, and (ii) the FDA-approved assay had a percentage of false negative results close to 1%. Together, in the present study, the domestic assay had a performance compatible with diagnosis purposes (given that this population was 70% HCV seropositive) but not compatible with HCV treatment monitoring (given that treatment failures are rare and the observed viremia frequently below the threshold of detection). This study highlights the need for a proper evaluation of HCV RNA domestic assays in order to efficiently contribute to the WHO HCV elimination target by 2030.
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- 2023
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3. The first successful bone marrow transplantation in Vietnam for a young Vietnamese boy with chronic granulomatous disease: a case report
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Binh Nguyen-Thanh, Le Nguyen-Ngoc-Quynh, Ha Dang-Thi, Chi Le-Quynh, Anh Nguyen-Thi-Van, Huyen Thuc-Thanh, Duong Dang-Anh, Pamela P. Lee, Tung Cao-Viet, and Dien Tran-Minh
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Vietnam ,case report ,bone marrow transplant ,Chronic granulomatous disease ,inborn error of immunity ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundChronic granulomatous disease (CGD) is an inborn error of immunity (IEI) disorder that results from defects in the respiratory burst activity in phagocytes, leading to the inability to kill bacterial and fungal microorganisms. CGD patients usually have a high incidence of morbidity such as infections and autoinflammatory diseases and a high mortality rate. Allogeneic bone marrow transplantation (BMT) is the only definitive cure for patients who suffer from CGD.Case presentationWe report the first transplant case of chronic granulomatous disease in Vietnam. A 25-month-old boy with X-linked CGD underwent bone marrow transplantation from his 5-year-old, full-matched human leukocyte antigen (HLA)-carrier sibling after myeloablative conditioning regimen with busulfan 5.1 mg/kg/day for 4 days, fludarabine 30 mg/m2/day for 5 days, and rATG (Grafalon-Fresenius) 10 mg/kg/day for 4 days. Neutrophil was engrafted on day 13 posttransplant, donor chimerism was 100% on day 30 with the dihydrorhodamine-1,2,3 (DHR 123) flow cytometric assay test that reached 38% of the normal 45 days posttransplant. Five months after transplant, the patient was free of infection with stable DHR 123 assay at 37%, and donor chimerism remained 100%. No sign of a graft-versus-host disease had been observed posttransplant.ConclusionWe suggest that bone marrow transplantation is a safe and effectual cure for CGD patients, especially for patients with HLA-identical siblings.
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- 2023
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4. Soil Moisture Influence on the FTIR Spectrum of Salt-Affected Soils.
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Hien, Le Thi Thu, Gobin, Anne, Lim, Duong Thi, Quan, Dang Tran, Hue, Nguyen Thi, Thang, Nguyen Ngoc, Binh, Nguyen Thanh, Dung, Vu Thi Kim, and Linh, Pham Ha
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SOIL salinity ,SOIL moisture ,FLUVISOLS ,SALINE irrigation ,SOILS ,INFRARED spectroscopy - Abstract
Soil salinity has a major impact on agricultural production. In a changing climate with rising sea-levels, low-lying coastal areas are increasingly inundated whereby saltwater gradually contaminates the soil. Drought prone areas may suffer from salinity due to high evapotranspiration rates in combination with the use of saline irrigation water. Salinity is difficult to monitor because soil moisture affects the soil's spectral signature. We conducted Fourier-transform infrared spectroscopy on alluvial and sandy soil samples in the coastal estuary of the Red River Delta. The soils are contaminated with NaCl, Na
2 CO3 and Na2 SO4 salts. In an experiment of salt contamination, we established that three ranges of the spectrum were strongly influenced by both salt and moisture content in the soil, at wavenumbers 3200–3400 cm−1 (2.9–3.1 µm); 1600–1700 cm−1 (5.9–6.3 µm); 900–1100 cm−1 (9.1–11.1 µm). The Na2 CO3 contaminated soil and the spectral value had a linear relationship between wavelengths 6.9 and 7.4 µm. At wavelength 6.99 µm, there was no relationship between absorbance and soil moisture, but the absorbance was proportional to the salt content (R2 = 0.85; RMSE = 0.68 g) and electrical conductivity (R2 = 0.50; RMSE = 3.8 dS/m). The relationship between soil moisture and spectral absorbance value was high at wavelengths below 6.7 µm, resulting in a quadratic relation between soil moisture and absorbance at wavelength 6.13 µm (R2 = 0.80; RMSE = 5.2%). The spectral signatures and equations might be useful for mapping salt-affected soils, particularly in difficult to access locations. Technological advances in thermal satellite sensors may offer possibilities for monitoring soil salinity. [ABSTRACT FROM AUTHOR]- Published
- 2022
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5. Hazardous alcohol use, antiretroviral therapy receipt, and viral suppression in people living with HIV who inject drugs in the United States, India, Russia, and Vietnam
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Jeffrey H. Samet, Joseph A.C. Delaney, Jennifer C. Elliott, Carlos del Rio, Jennifer A. Wagman, Gregory M. Lucas, Redonna K. Chandler, Binh Nguyen Thanh, Daniel J. Feaster, Sandra A. Springer, Judith I. Tsui, Bridget M. Whitney, Frederick L. Altice, Heidi M. Crane, Mika Matsuzaki, Robin M. Nance, Adriane Wynn, Wafaa M. El-Sadr, Natalia Gnatienko, Lisa R. Metsch, Shoshana Y. Kahana, Quan Vu, Shruti H. Mehta, and Yael Hirsch-Moverman
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0301 basic medicine ,Male ,people who inject drugs ,Alcohol ,HIV Infections ,Logistic regression ,Medical and Health Sciences ,Russia ,Alcohol Use and Health ,chemistry.chemical_compound ,0302 clinical medicine ,Immunology and Allergy ,Medicine ,030212 general & internal medicine ,Viral suppression ,Substance Abuse, Intravenous ,Receipt ,Alcohol Use Disorders Identification Test ,Substance Abuse ,Biological Sciences ,Middle Aged ,Viral Load ,Alcoholism ,Infectious Diseases ,Anti-Retroviral Agents ,Vietnam ,HIV/AIDS ,Female ,Intravenous ,Infection ,Viral load ,Alcohol-Related Disorders ,Adult ,viral suppression ,Immunology ,India ,Article ,hazardous alcohol use ,03 medical and health sciences ,Clinical Research ,Virology ,Behavioral and Social Science ,Humans ,people living with HIV ,business.industry ,Prevention ,Psychology and Cognitive Sciences ,Odds ratio ,HIV infection ,Confidence interval ,United States ,middle-income country ,030104 developmental biology ,Cross-Sectional Studies ,chemistry ,antiretroviral receipt ,business ,high-income country ,Demography - Abstract
Author(s): Wagman, Jennifer A; Wynn, Adriane; Matsuzaki, Mika; Gnatienko, Natalia; Metsch, Lisa R; Del Rio, Carlos; Feaster, Daniel J; Nance, Robin M; Whitney, Bridget M; Delaney, Joseph AC; Kahana, Shoshana Y; Crane, Heidi M; Chandler, Redonna K; Elliott, Jennifer C; Altice, Frederick; Lucas, Gregory M; Mehta, Shruti H; Hirsch-Moverman, Yael; El-Sadr, Wafaa M; Vu, Quan; Nguyen Thanh, Binh; Springer, Sandra A; Tsui, Judith I; Samet, Jeffrey H | Abstract: ObjectivesIn high-income countries, hazardous alcohol use is associated with reduced receipt of antiretroviral therapy (ART) and viral suppression among people living with HIV (PLHIV) who inject drugs. These associations are less understood in lower middle-income countries (LMIC) and upper middle-income countries.DesignWe examined associations between hazardous alcohol use, ART receipt, and viral suppression among PLHIV who reported current or former injection drug use. Participants were from nine studies in the United States (high-income country), India (LMIC), Russia (upper middle-income country), and Vietnam (LMIC).MethodsHazardous alcohol use was measured via Alcohol Use Disorders Identification Test. Outcomes were HIV viral suppression (viral load of l1000 RNA copies/ml) and self-reported ART receipt. Logistic regression assessed associations between hazardous alcohol use and both outcome variables, controlling for age and sex, among participants with current and former injection drug use.ResultsAmong 2790 participants, 16% were women, mean age was 37.1 ± 9.5 years. Mean Alcohol Use Disorders Identification Test scores were 4.6 ± 8.1 (women) and 6.2 ± 8.3 (men); 42% reported ART receipt; 40% had viral suppression. Hazardous alcohol use was significantly associated with reduced ART receipt in India (adjusted odds ratio = 0.59, 95% confidence interval: 0.45-0.77, P l 0.001); and lower rates of viral suppression in Vietnam (adjusted odds ratio = 0.51, 95% confidence interval: 0.31-0.82, P = 0.006).ConclusionAssociations between hazardous alcohol use, ART receipt, and viral suppression varied across settings and were strongest in LMICs. Addressing hazardous alcohol use holds promise for improving HIV continuum of care outcomes among PLHIV who inject drugs. Specific impact and intervention needs may differ by setting.
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- 2020
6. First field evaluation of the optimized CE marked Abbott protocol for HIV RNA testing on dried blood spot in a routine clinical setting in Vietnam
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Hien Ba Pham, Dung Viet Ta, Fabien Taieb, Binh Nguyen Thanh, Hau Tran Thi Bich, Tram Pham Phuong, Lan Thi Huong Nguyen, Yoann Madec, Thu Trang Nguyen, Tram Tran Hong, Huong Le Thi, Huong T. H. Nguyen, Nhung Le Thi Hong, Hien Thi Ho, Edouard Tuaillon, Eric Delaporte, Tuan Anh Nguyen, Centre de Recherche Translationnelle - Center for Translational Science (CRT), Institut Pasteur [Paris], Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), National Institute of Hygiene and Epidemiology [Hanoi, Vietnam] (NIHE), Réseau International des Instituts Pasteur (RIIP), Chercheur indépendant, Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Abbott Company, Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), and Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
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0301 basic medicine ,RNA viruses ,Physiology ,Epidemiology ,lcsh:Medicine ,HIV Infections ,Pathology and Laboratory Medicine ,Geographical Locations ,MESH: HIV-1 ,Immunodeficiency Viruses ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Medicine and Health Sciences ,Public and Occupational Health ,lcsh:Science ,Dried blood ,Multidisciplinary ,Remote area ,AIDS Serodiagnosis ,MESH: HIV Infections ,Viral Load ,Vaccination and Immunization ,3. Good health ,Dried blood spot ,Body Fluids ,Blood ,Vietnam ,Medical Microbiology ,HIV epidemiology ,Viral Pathogens ,MESH: RNA, Viral ,Viruses ,RNA, Viral ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Anatomy ,Pathogens ,Viral load ,Research Article ,medicine.medical_specialty ,Asia ,030106 microbiology ,Immunology ,Antiretroviral Therapy ,Sensitivity and Specificity ,Microbiology ,Blood Plasma ,Central laboratory ,03 medical and health sciences ,Antiviral Therapy ,Virology ,Retroviruses ,medicine ,Humans ,Microbial Pathogens ,Protocol (science) ,MESH: Humans ,business.industry ,lcsh:R ,Lentivirus ,Organisms ,Biology and Life Sciences ,HIV ,MESH: Sensitivity and Specificity ,MESH: AIDS Serodiagnosis ,Emergency medicine ,People and Places ,HIV-1 ,lcsh:Q ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Preventive Medicine ,MESH: Vietnam ,business ,Viral Transmission and Infection - Abstract
Background Viral load (VL) monitoring of HIV-infected patients in decentralized areas is limited due to logistic constraints. Dried Blood Spots (DBS) offer the opportunity to collect samples in remote area which can be easily transferred and tested at a central laboratory. The MOVIDA (Monitoring Of Viral load In Decentralized Area) project evaluated the performance of VL measurements on DBS using the new CE marked optimized Abbott protocol. Methods HIV-1 infected adults from three outpatient clinics in Hanoi (Vietnam) were enrolled into the study between 1 March and 13 April 2017. VL was measured on DBS using the optimized protocol provided by the manufacturer and compared to plasma VL as reference method on the Abbott m2000rt RealTime HIV-1 platform. Sensitivity was defined as the ability for DBS samples to correctly identify VL failure at the threshold of 1000 copies/mL of plasma, while specificity represented the ability to identify patients with a plasma HIV-RNA VL of
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- 2018
7. "In their perception we are addicts": social vulnerabilities and sources of support for men released from drug treatment centers in Vietnam.
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Tomori, Cecilia, Go, Vivian F, Tuan, Le Nhan, Huong, Nguyen Mai, Binh, Nguyen Thanh, Zelaya, Carla E, Celentano, David D, Dat, Do Tuan, and Quan, Vu Minh
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Background: Amid the global transition to treat opioid addiction as an illness, many people who inject drugs (PWID) face heterogeneous legal environments that include both punitive and harm reduction measures. In Vietnam, many PWID, who have a high burden of HIV, are sent to drug treatment centers, or "06 centers", for compulsory detoxification, vocational training, and labor for up to four years. This study investigates the challenges and facilitators of reentry into community and family life among men who are released from "06 centers" and provides insights and recommendations for developing policies and interventions that address special needs of this vulnerable population.Methods: In-depth interviews were conducted in 2011 by trained interviewers among a sample of 43 male PWID released within the past 2 years from "06 centers" in Hanoi, Vietnam to investigate the above issues and to recommend potential interventions. Participants were recruited from outpatient HIV clinics that serve PWID (n=22) and through peer referral from self-help groups for PWID (n=21). Interviews were audiotaped, transcribed, translated, entered into Atlas.TI qualitative data analysis software and analyzed for key themes.Results: The interviews revealed persistent drug-related stigmatization, frequently paired with HIV-related stigmatization and discrimination, which hindered employment, increased participants' social isolation and exacerbated their struggles with addiction. Families were participants' primary source of financial, employment, and emotional support, but addiction-related family tensions also had negative psychological effects. Participants identified methadone maintenance treatment as an effective means of overcoming addiction, yet few could fully benefit from this treatment due to its limited availability.Conclusion: Our study suggests that PWID released from "06 centers" would greatly benefit from the scale-up of community-based harm reduction measures that include addiction and HIV treatment, coupled with employment-support and family centered mental health services. [ABSTRACT FROM AUTHOR]- Published
- 2014
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